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Antibacterial ability and hemocompatibility of graphene functionalized germanium

View Article: PubMed Central - PubMed

ABSTRACT

Germanium (Ge), as an elemental semiconductor material, has been an attractive candidate for manufacturing semiconductor microelectronic device. In the present investigation, to improve the biocompatibility of Ge-based device, graphene film is directly deposited on the Ge surface with different coverage area by controlling the growth time. Compared to bare Ge, the presence of graphene film entitles Ge with satisfactory antibacterial ability against Staphylococcus aureus (S.aureus), and acceptable antibacterial ability against Escherichia coli (E. coli). Meanwhile, antibacterial efficiency closely correlates with coverage area of graphene film, and larger graphene coverage always leads to better antibacterial performance. The underlying mechanism is thought to be the integrative action of phospholipids disturbance and electron extraction at the interface between graphene and biomembrane. Meanwhile, the electron extraction action would further lead to the activation of platelet. This study might provide some new insights into the relationship between antibacterial ability and hemocompatibility based on graphene functionalized biomedical device.

No MeSH data available.


Potentiodynamic polarization curves of None-Gr, Half-Gr and Full-Gr in 0.9% physiological saline solution.
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f2: Potentiodynamic polarization curves of None-Gr, Half-Gr and Full-Gr in 0.9% physiological saline solution.

Mentions: Corrosion resistance is one of the significant factors to be considered in course of practical application of biomedical devices. In order to evaluate the impact of the graphene coverage area on the corrosion resistance of the underlying Ge, the dynamic potential curve test was conducted in the physiological saline (0.9 wt% NaCl solution). As depicted in Fig. 2, the corrosion potential shows distinct positive shift for both Half-Gr and Full-Gr compared to the None-Gr, which indicates a lower corrosion tendency for graphene covered ones. Moreover, it can be found that Ge substrate covered by the continuous graphene film exhibits better corrosion resistance compared to that covered by the partial graphene film. Therefore, it is concluded that graphene film can act as a protective layer for Ge-based device in corrosion medium.


Antibacterial ability and hemocompatibility of graphene functionalized germanium
Potentiodynamic polarization curves of None-Gr, Half-Gr and Full-Gr in 0.9% physiological saline solution.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120343&req=5

f2: Potentiodynamic polarization curves of None-Gr, Half-Gr and Full-Gr in 0.9% physiological saline solution.
Mentions: Corrosion resistance is one of the significant factors to be considered in course of practical application of biomedical devices. In order to evaluate the impact of the graphene coverage area on the corrosion resistance of the underlying Ge, the dynamic potential curve test was conducted in the physiological saline (0.9 wt% NaCl solution). As depicted in Fig. 2, the corrosion potential shows distinct positive shift for both Half-Gr and Full-Gr compared to the None-Gr, which indicates a lower corrosion tendency for graphene covered ones. Moreover, it can be found that Ge substrate covered by the continuous graphene film exhibits better corrosion resistance compared to that covered by the partial graphene film. Therefore, it is concluded that graphene film can act as a protective layer for Ge-based device in corrosion medium.

View Article: PubMed Central - PubMed

ABSTRACT

Germanium (Ge), as an elemental semiconductor material, has been an attractive candidate for manufacturing semiconductor microelectronic device. In the present investigation, to improve the biocompatibility of Ge-based device, graphene film is directly deposited on the Ge surface with different coverage area by controlling the growth time. Compared to bare Ge, the presence of graphene film entitles Ge with satisfactory antibacterial ability against Staphylococcus aureus (S.aureus), and acceptable antibacterial ability against Escherichia coli (E. coli). Meanwhile, antibacterial efficiency closely correlates with coverage area of graphene film, and larger graphene coverage always leads to better antibacterial performance. The underlying mechanism is thought to be the integrative action of phospholipids disturbance and electron extraction at the interface between graphene and biomembrane. Meanwhile, the electron extraction action would further lead to the activation of platelet. This study might provide some new insights into the relationship between antibacterial ability and hemocompatibility based on graphene functionalized biomedical device.

No MeSH data available.