Limits...
The trend and the disease prediction of vascular endothelial growth factor and placenta growth factor in nontuberculous mycobacterial lung disease

View Article: PubMed Central - PubMed

ABSTRACT

Nontuberculous mycobacteria (NTM)-lung disease (LD) is an increasing health problem worldwide. The diagnosis of this disease remains difficult, however the application of placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) has not yet been studied. We screened patients with Mycobacterium avium complex or M. abscessus isolated from sputum, and enrolled 32 patients with NTM-LD and 93 with NTM pulmonary colonization. The NTM-LD group had a lower body mass index, higher proportion of bronchiectasis, more respiratory symptoms and pulmonary lesions, and higher titers of sputum acid-fast stain than the NTM pulmonary colonization group. The plasma level of PlGF was lower in the NTM-LD group than in the NTM colonization group, whereas the level of VEGF was higher in the NTM-LD group. In multivariable logistic regression analysis excluding NTM cultures, the predictive model for NTM-LD included sputum AFS titer, a nodular-bronchiectasis radiographic pattern, plasma VEGF/PlGF ratio, and chest radiographic score (VEGF/P1GF ratio became not significant as a factor in multivariable generalized linear model). The four-factor predictive index had good positive likelihood ratio and negative likelihood ratio for predicting NTM-LD in the patients with NTM in their sputum.

No MeSH data available.


Related in: MedlinePlus

Plasma levels of (A) placenta growth factor (PlGF), (B) vascular endothelial growth factor (VEGF), and (C) their ratio according to nontuberculous mycobacteria (NTM)-lung disease (LD), pulmonary colonization (col), and control group. The cross lines are mean value and error bars are standard error of the mean. ns, not statistically significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC5120340&req=5

f2: Plasma levels of (A) placenta growth factor (PlGF), (B) vascular endothelial growth factor (VEGF), and (C) their ratio according to nontuberculous mycobacteria (NTM)-lung disease (LD), pulmonary colonization (col), and control group. The cross lines are mean value and error bars are standard error of the mean. ns, not statistically significant.

Mentions: The plasma level of PlGF was higher in the NTM colonization group than in the NTM-LD group (45.0 vs. 13.4 pg/ml, p = 0.019), and the PlGF level in the NTM-LD group was lower than in the control group (13.4 vs. 26.18 pg/ml, p = 0.040) (Fig. 2). However, the plasma level of VEGF was higher in the NTM-LD group than in the NTM pulmonary colonization group (24.1 vs. 14.7 pg/ml, p = 0.035). The ratio of VEGF divided by PlGF was higher in the NTM-LD group than in the colonization group (2.7 vs. 1.6, p = 0.042).


The trend and the disease prediction of vascular endothelial growth factor and placenta growth factor in nontuberculous mycobacterial lung disease
Plasma levels of (A) placenta growth factor (PlGF), (B) vascular endothelial growth factor (VEGF), and (C) their ratio according to nontuberculous mycobacteria (NTM)-lung disease (LD), pulmonary colonization (col), and control group. The cross lines are mean value and error bars are standard error of the mean. ns, not statistically significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120340&req=5

f2: Plasma levels of (A) placenta growth factor (PlGF), (B) vascular endothelial growth factor (VEGF), and (C) their ratio according to nontuberculous mycobacteria (NTM)-lung disease (LD), pulmonary colonization (col), and control group. The cross lines are mean value and error bars are standard error of the mean. ns, not statistically significant.
Mentions: The plasma level of PlGF was higher in the NTM colonization group than in the NTM-LD group (45.0 vs. 13.4 pg/ml, p = 0.019), and the PlGF level in the NTM-LD group was lower than in the control group (13.4 vs. 26.18 pg/ml, p = 0.040) (Fig. 2). However, the plasma level of VEGF was higher in the NTM-LD group than in the NTM pulmonary colonization group (24.1 vs. 14.7 pg/ml, p = 0.035). The ratio of VEGF divided by PlGF was higher in the NTM-LD group than in the colonization group (2.7 vs. 1.6, p = 0.042).

View Article: PubMed Central - PubMed

ABSTRACT

Nontuberculous mycobacteria (NTM)-lung disease (LD) is an increasing health problem worldwide. The diagnosis of this disease remains difficult, however the application of placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) has not yet been studied. We screened patients with Mycobacterium avium complex or M. abscessus isolated from sputum, and enrolled 32 patients with NTM-LD and 93 with NTM pulmonary colonization. The NTM-LD group had a lower body mass index, higher proportion of bronchiectasis, more respiratory symptoms and pulmonary lesions, and higher titers of sputum acid-fast stain than the NTM pulmonary colonization group. The plasma level of PlGF was lower in the NTM-LD group than in the NTM colonization group, whereas the level of VEGF was higher in the NTM-LD group. In multivariable logistic regression analysis excluding NTM cultures, the predictive model for NTM-LD included sputum AFS titer, a nodular-bronchiectasis radiographic pattern, plasma VEGF/PlGF ratio, and chest radiographic score (VEGF/P1GF ratio became not significant as a factor in multivariable generalized linear model). The four-factor predictive index had good positive likelihood ratio and negative likelihood ratio for predicting NTM-LD in the patients with NTM in their sputum.

No MeSH data available.


Related in: MedlinePlus