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Folic acid supplementation improves cognitive function by reducing the levels of peripheral inflammatory cytokines in elderly Chinese subjects with MCI

View Article: PubMed Central - PubMed

ABSTRACT

This study aimed to evaluate whether folic acid supplementation would improve cognitive performance by reducing serum inflammatory cytokine concentrations. This RCT was performed in Tianjin, China. Participants with mild cognitive impairment (MCI) were randomly assigned to the folic acid (400 μg/day) or conventional treatment groups. Neuropsychological tests were administered, and folate, homocysteine, vitamin B12, IL-6, TNF-α, Aβ-42, and Aβ-40 were measured at baseline and at 6- and 12-month time points.152 participants (folic acid: 77, conventional: 75) completed the trial. Significant improvements in folate (ηp2 = 0.703, P = 0.011), homocysteine (ηp2 = 0.644, P = 0.009), Aβ-42 (ηp2 = 0.687, P = 0.013), peripheral IL-6 (ηp2 = 0.477, P = 0.025), TNF-α (ηp2 = 0.709, P = 0.009) levels were observed in folic acid group compared with conventional group. Folic acid supplementation improved the Full Scale Intelligence Quotient (P = 0.028; effect size d = 0.153), Information (P = 0.031; d = 0.157) and Digit Span (P = 0.009; d = 0.172) scores at 12 months compared with conventional treatment. Based on these findings, daily oral administration of a 400-μg folic acid supplement to MCI subjects for 12 months can significantly improve cognitive performance and reduce peripheral inflammatory cytokine levels.

No MeSH data available.


Flow diagram of the subjects’ enrollment from the initial contact through study completion.
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f1: Flow diagram of the subjects’ enrollment from the initial contact through study completion.

Mentions: Using random cluster sampling, six geographically convenient communities with a high proportion of older residents who were all native Chinese speakers were selected from the Binhai New District, Tianjin, China. Of the 4215 individuals selected, 2816 (66.8%) agreed to participate, but only 2293 participants were eligible for the clinical, physical, and neuropsychological examinations. Two hundred ten subjects with MCI were selected from these individuals using previously determined criteria for MCI (Fig. 1). Of the 210 MCI individuals screened, 168 met the inclusion criteria and were assigned randomly to the folic acid supplementation or conventional-treatment groups. Dropout rates were 8.33% (7/84) in the folic acid group and 10.7% (9/84) in the conventional-treatment group. There was no significant difference in dropout rates between the two groups (χ2 = 0.276, P = 0.834). Baseline characteristics of the study population are shown in Table 1.


Folic acid supplementation improves cognitive function by reducing the levels of peripheral inflammatory cytokines in elderly Chinese subjects with MCI
Flow diagram of the subjects’ enrollment from the initial contact through study completion.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120319&req=5

f1: Flow diagram of the subjects’ enrollment from the initial contact through study completion.
Mentions: Using random cluster sampling, six geographically convenient communities with a high proportion of older residents who were all native Chinese speakers were selected from the Binhai New District, Tianjin, China. Of the 4215 individuals selected, 2816 (66.8%) agreed to participate, but only 2293 participants were eligible for the clinical, physical, and neuropsychological examinations. Two hundred ten subjects with MCI were selected from these individuals using previously determined criteria for MCI (Fig. 1). Of the 210 MCI individuals screened, 168 met the inclusion criteria and were assigned randomly to the folic acid supplementation or conventional-treatment groups. Dropout rates were 8.33% (7/84) in the folic acid group and 10.7% (9/84) in the conventional-treatment group. There was no significant difference in dropout rates between the two groups (χ2 = 0.276, P = 0.834). Baseline characteristics of the study population are shown in Table 1.

View Article: PubMed Central - PubMed

ABSTRACT

This study aimed to evaluate whether folic acid supplementation would improve cognitive performance by reducing serum inflammatory cytokine concentrations. This RCT was performed in Tianjin, China. Participants with mild cognitive impairment (MCI) were randomly assigned to the folic acid (400 μg/day) or conventional treatment groups. Neuropsychological tests were administered, and folate, homocysteine, vitamin B12, IL-6, TNF-α, Aβ-42, and Aβ-40 were measured at baseline and at 6- and 12-month time points.152 participants (folic acid: 77, conventional: 75) completed the trial. Significant improvements in folate (ηp2 = 0.703, P = 0.011), homocysteine (ηp2 = 0.644, P = 0.009), Aβ-42 (ηp2 = 0.687, P = 0.013), peripheral IL-6 (ηp2 = 0.477, P = 0.025), TNF-α (ηp2 = 0.709, P = 0.009) levels were observed in folic acid group compared with conventional group. Folic acid supplementation improved the Full Scale Intelligence Quotient (P = 0.028; effect size d = 0.153), Information (P = 0.031; d = 0.157) and Digit Span (P = 0.009; d = 0.172) scores at 12 months compared with conventional treatment. Based on these findings, daily oral administration of a 400-μg folic acid supplement to MCI subjects for 12 months can significantly improve cognitive performance and reduce peripheral inflammatory cytokine levels.

No MeSH data available.