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A Meta-analysis of MBL2 Polymorphisms and Tuberculosis Risk

View Article: PubMed Central - PubMed

ABSTRACT

MBL2 gene encodes mannose-binding lectin, is a member of innate immune system. Earlier studies revealed that MBL2 gene variants, rs1800451, rs1800450, rs5030737, rs7096206, rs11003125 and rs7095891 are associated with impaired serum level and susceptibility to TB, but their results are inconsistent. A meta-analysis was performed by including 22 studies (7095 TB-patients and 7662 controls) and data were analyzed with respect to associations between alleles, genotypes and minor allele carriers to evaluate the potential association between MBL2 polymorphisms and TB risk. Statistically significant results were found only for the homozygous variant genotype (CC vs. AA: p = 0.045; OR = 0.834, 95% CI = 0.699 to 0.996) of rs1800451 and showed reduced risk of TB in overall population. However, other genetic models of rs1800450, rs5030737, rs7096206, rs11003125, rs7095891 and combined rs1800450, rs1800451, rs5030737 polymorphisms of MBL2 gene did not reveal any association with TB risk. Stratified analysis by ethnicity showed decreased risk of TB in African population for rs1800450 and rs1800451. Whereas, no association was observed between other MBL2 polymorphisms and TB risk in all the evaluated ethnic populations. In conclusion, MBL2 rs1800450 and rs1800451 polymorphisms play a protective role in TB infection and reinforce their critical significance as a potential genetic marker for TB resistance.

No MeSH data available.


Forest plot of ORs with 95% CI of TB risk associated with the MBL2 combined rs1800450, rs1800451, rs5030737 (A > O) exon 1 gene polymorphisms for overall population.Black square represents the value of OR and the size of the square indicates the inverse proportion relative to its variance. Horizontal line is the 95% CI of OR.
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f5: Forest plot of ORs with 95% CI of TB risk associated with the MBL2 combined rs1800450, rs1800451, rs5030737 (A > O) exon 1 gene polymorphisms for overall population.Black square represents the value of OR and the size of the square indicates the inverse proportion relative to its variance. Horizontal line is the 95% CI of OR.

Mentions: In this analysis, a total of 10 case-control studies involving 2040 control subjects and 1945 confirmed TB cases were taken into consideration and provided sufficient data to calculate ORs. No publication bias was found during the analysis, while, heterogeneity was detected in all the genetic models (Table 8) (SI: Figure SI11). The pooled ORs of this analysis revealed that combined A > O exon 1 polymorphism is not associated with TB in allelic contrast (O vs. A: p = 0.150; OR = 1.303, 95% CI = 0.909 to 1.869), homozygous (OO vs. AA: p = 0.076; OR = 2.246, 95% CI = 0.920 to 5.483), heterozygous (AO vs. AA: p = 0.289; OR = 1.224, 95% CI = 0.842 to 1.779), dominant (OO + AO vs. AA: p = 0.061; OR = 0.504, 95% CI = 0.246 to 1.033), and recessive (OO vs. AA + AO: p = 0.194; OR = 1.321, 95% CI = 0.868 to 2.011) genetic models (Fig. 5).


A Meta-analysis of MBL2 Polymorphisms and Tuberculosis Risk
Forest plot of ORs with 95% CI of TB risk associated with the MBL2 combined rs1800450, rs1800451, rs5030737 (A > O) exon 1 gene polymorphisms for overall population.Black square represents the value of OR and the size of the square indicates the inverse proportion relative to its variance. Horizontal line is the 95% CI of OR.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120291&req=5

f5: Forest plot of ORs with 95% CI of TB risk associated with the MBL2 combined rs1800450, rs1800451, rs5030737 (A > O) exon 1 gene polymorphisms for overall population.Black square represents the value of OR and the size of the square indicates the inverse proportion relative to its variance. Horizontal line is the 95% CI of OR.
Mentions: In this analysis, a total of 10 case-control studies involving 2040 control subjects and 1945 confirmed TB cases were taken into consideration and provided sufficient data to calculate ORs. No publication bias was found during the analysis, while, heterogeneity was detected in all the genetic models (Table 8) (SI: Figure SI11). The pooled ORs of this analysis revealed that combined A > O exon 1 polymorphism is not associated with TB in allelic contrast (O vs. A: p = 0.150; OR = 1.303, 95% CI = 0.909 to 1.869), homozygous (OO vs. AA: p = 0.076; OR = 2.246, 95% CI = 0.920 to 5.483), heterozygous (AO vs. AA: p = 0.289; OR = 1.224, 95% CI = 0.842 to 1.779), dominant (OO + AO vs. AA: p = 0.061; OR = 0.504, 95% CI = 0.246 to 1.033), and recessive (OO vs. AA + AO: p = 0.194; OR = 1.321, 95% CI = 0.868 to 2.011) genetic models (Fig. 5).

View Article: PubMed Central - PubMed

ABSTRACT

MBL2 gene encodes mannose-binding lectin, is a member of innate immune system. Earlier studies revealed that MBL2 gene variants, rs1800451, rs1800450, rs5030737, rs7096206, rs11003125 and rs7095891 are associated with impaired serum level and susceptibility to TB, but their results are inconsistent. A meta-analysis was performed by including 22 studies (7095 TB-patients and 7662 controls) and data were analyzed with respect to associations between alleles, genotypes and minor allele carriers to evaluate the potential association between MBL2 polymorphisms and TB risk. Statistically significant results were found only for the homozygous variant genotype (CC vs. AA: p = 0.045; OR = 0.834, 95% CI = 0.699 to 0.996) of rs1800451 and showed reduced risk of TB in overall population. However, other genetic models of rs1800450, rs5030737, rs7096206, rs11003125, rs7095891 and combined rs1800450, rs1800451, rs5030737 polymorphisms of MBL2 gene did not reveal any association with TB risk. Stratified analysis by ethnicity showed decreased risk of TB in African population for rs1800450 and rs1800451. Whereas, no association was observed between other MBL2 polymorphisms and TB risk in all the evaluated ethnic populations. In conclusion, MBL2 rs1800450 and rs1800451 polymorphisms play a protective role in TB infection and reinforce their critical significance as a potential genetic marker for TB resistance.

No MeSH data available.