Limits...
The Effects of Hemodynamic Changes on Pulse Wave Velocity in Cardiothoracic Surgical Patients

View Article: PubMed Central - PubMed

ABSTRACT

The effect of blood pressure on pulse wave velocity (PWV) is well established. However, PWV variability with acute hemodynamic changes has not been examined in the clinical setting. The aim of the present study is to investigate the effect of hemodynamic changes on PWV in patients who undergo cardiothoracic surgery. Using data from 25 patients, we determined blood pressure (BP), heart rate (HR), and the left ventricular outflow tract (LVOT) velocity-time integral. By superimposing the radial arterial waveform on the continuous wave Doppler waveform of the LVOT, obtained by transesophageal echo, we were able to determine pulse transit time and to calculate PWV, stroke volume (SV), cardiac output (CO), and systemic vascular resistance (SVR). Increases in BP, HR, and SVR were associated with higher values for PWV. In contrast increases in SV were associated with decreases in PWV. Changes in CO were not significantly associated with PWV.

No MeSH data available.


Related in: MedlinePlus

The relationship between PWV and BP. Each line indicates a simple linear regression line within subject. (a) The relationship between PWV and SBP. (b) The relationship between PWV and MAP. (c) The relationship between PWV and DBP. (d) The relationship between PWV and PP. The median (IQR) slope and the median (IQR) P value are presented in each graph. BP: blood pressure, DBP: diastolic blood pressure, IQR: interquartile range, MAP: mean arterial pressure, PP: pulse pressure, PWV: pulse wave velocity, and SBP: systolic blood pressure.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC5120184&req=5

fig2: The relationship between PWV and BP. Each line indicates a simple linear regression line within subject. (a) The relationship between PWV and SBP. (b) The relationship between PWV and MAP. (c) The relationship between PWV and DBP. (d) The relationship between PWV and PP. The median (IQR) slope and the median (IQR) P value are presented in each graph. BP: blood pressure, DBP: diastolic blood pressure, IQR: interquartile range, MAP: mean arterial pressure, PP: pulse pressure, PWV: pulse wave velocity, and SBP: systolic blood pressure.

Mentions: There was a significant correlation between PWV and BP (SBP, MAP, DBP, and PP) within individual patients (Figure 2). Given that each patient had a different linear regression line with a different P value, the overall trend for all regression lines was estimated by a linear mixed model and presented in Table 2. A positive correlation was observed between PWV and SBP (slope: 0.016, P < 0.001), DBP (slope: 0.03, P < 0.001), PP (slope: 0.026, P < 0.001), and MAP (slope: 0.024, P < 0.001).


The Effects of Hemodynamic Changes on Pulse Wave Velocity in Cardiothoracic Surgical Patients
The relationship between PWV and BP. Each line indicates a simple linear regression line within subject. (a) The relationship between PWV and SBP. (b) The relationship between PWV and MAP. (c) The relationship between PWV and DBP. (d) The relationship between PWV and PP. The median (IQR) slope and the median (IQR) P value are presented in each graph. BP: blood pressure, DBP: diastolic blood pressure, IQR: interquartile range, MAP: mean arterial pressure, PP: pulse pressure, PWV: pulse wave velocity, and SBP: systolic blood pressure.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120184&req=5

fig2: The relationship between PWV and BP. Each line indicates a simple linear regression line within subject. (a) The relationship between PWV and SBP. (b) The relationship between PWV and MAP. (c) The relationship between PWV and DBP. (d) The relationship between PWV and PP. The median (IQR) slope and the median (IQR) P value are presented in each graph. BP: blood pressure, DBP: diastolic blood pressure, IQR: interquartile range, MAP: mean arterial pressure, PP: pulse pressure, PWV: pulse wave velocity, and SBP: systolic blood pressure.
Mentions: There was a significant correlation between PWV and BP (SBP, MAP, DBP, and PP) within individual patients (Figure 2). Given that each patient had a different linear regression line with a different P value, the overall trend for all regression lines was estimated by a linear mixed model and presented in Table 2. A positive correlation was observed between PWV and SBP (slope: 0.016, P < 0.001), DBP (slope: 0.03, P < 0.001), PP (slope: 0.026, P < 0.001), and MAP (slope: 0.024, P < 0.001).

View Article: PubMed Central - PubMed

ABSTRACT

The effect of blood pressure on pulse wave velocity (PWV) is well established. However, PWV variability with acute hemodynamic changes has not been examined in the clinical setting. The aim of the present study is to investigate the effect of hemodynamic changes on PWV in patients who undergo cardiothoracic surgery. Using data from 25 patients, we determined blood pressure (BP), heart rate (HR), and the left ventricular outflow tract (LVOT) velocity-time integral. By superimposing the radial arterial waveform on the continuous wave Doppler waveform of the LVOT, obtained by transesophageal echo, we were able to determine pulse transit time and to calculate PWV, stroke volume (SV), cardiac output (CO), and systemic vascular resistance (SVR). Increases in BP, HR, and SVR were associated with higher values for PWV. In contrast increases in SV were associated with decreases in PWV. Changes in CO were not significantly associated with PWV.

No MeSH data available.


Related in: MedlinePlus