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Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy

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ABSTRACT

Background. The IL-33/ST2 axis is involved in humoral immune responses. Method. The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA. Clinical and laboratory data were examined. The potential association between sera IL-33 and sST2 and the clinical parameters in IgAN patients were analyzed. Results. No difference was discovered in IL-33 concentrations between IgAN patients and HCs; however, the sST2 were significantly higher in each stage of IgAN progression than in the HC. The concentration of sST2 was positively correlated with IL-33 levels in IgAN patients. Higher levels of sera IL-2, IL-4, IL-10, IL-17A, and IFN-γ were detected in patients compared to the HC. The concentration of serum sST2 was positively correlated with the levels of IL-10 in IgAN patients. Furthermore, serum sST2 was negatively correlated with the values of eGFR and serum calcium. Serum sST2 was positively correlated with 24-hour urinary protein, serum phosphorus, and serum IgA; however, serum IL-33 was not associated with these. Following treatment, serum sST2 was significantly decreased, while sera IL-4 and IL-10 were significantly increased. Conclusions. Increased sST2 and IL-10 but not IL-33 may be involved in the pathogenic process of IgAN.

No MeSH data available.


Correlation analysis of serum sST2 with the levels of IL-2, IL-4, IL-10, IL-17A, and IFN-γ in IgAN patients. The potential correlations between serum sST2 and the levels of IL-2, IL-4, IL-10, IL-17A, and IFN-γ were analyzed by Spearman correlation tests. Data shown are the mean concentration of individual subjects from two separate experiments. (a) Serum sST2 levels were correlated positively with IL-10. ((b)–(e)) No correlation was found between serum sST2 and the levels of IL-2, IL-4, IL-17A, and IFN-γ in IgAN patients, respectively.
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fig5: Correlation analysis of serum sST2 with the levels of IL-2, IL-4, IL-10, IL-17A, and IFN-γ in IgAN patients. The potential correlations between serum sST2 and the levels of IL-2, IL-4, IL-10, IL-17A, and IFN-γ were analyzed by Spearman correlation tests. Data shown are the mean concentration of individual subjects from two separate experiments. (a) Serum sST2 levels were correlated positively with IL-10. ((b)–(e)) No correlation was found between serum sST2 and the levels of IL-2, IL-4, IL-17A, and IFN-γ in IgAN patients, respectively.

Mentions: To comprehend the importance of sST2 in the pathogenesis of IgAN, we explored the potential association of the serum sST2 with the levels of IL-2, IL-4, IL-10, IL-17A, and IFN-γ in patients. We found that serum sST2 correlated positively with the level of IL-10 (r = 0.4796, p = 0.0013, Figure 5(a)), whereas there was no significant correlation between serum sST2 and the levels of IL-2, IL-4, IL-17A, and IFN-γ in IgAN patients (Figures 5(b)–5(e)).


Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy
Correlation analysis of serum sST2 with the levels of IL-2, IL-4, IL-10, IL-17A, and IFN-γ in IgAN patients. The potential correlations between serum sST2 and the levels of IL-2, IL-4, IL-10, IL-17A, and IFN-γ were analyzed by Spearman correlation tests. Data shown are the mean concentration of individual subjects from two separate experiments. (a) Serum sST2 levels were correlated positively with IL-10. ((b)–(e)) No correlation was found between serum sST2 and the levels of IL-2, IL-4, IL-17A, and IFN-γ in IgAN patients, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC5120178&req=5

fig5: Correlation analysis of serum sST2 with the levels of IL-2, IL-4, IL-10, IL-17A, and IFN-γ in IgAN patients. The potential correlations between serum sST2 and the levels of IL-2, IL-4, IL-10, IL-17A, and IFN-γ were analyzed by Spearman correlation tests. Data shown are the mean concentration of individual subjects from two separate experiments. (a) Serum sST2 levels were correlated positively with IL-10. ((b)–(e)) No correlation was found between serum sST2 and the levels of IL-2, IL-4, IL-17A, and IFN-γ in IgAN patients, respectively.
Mentions: To comprehend the importance of sST2 in the pathogenesis of IgAN, we explored the potential association of the serum sST2 with the levels of IL-2, IL-4, IL-10, IL-17A, and IFN-γ in patients. We found that serum sST2 correlated positively with the level of IL-10 (r = 0.4796, p = 0.0013, Figure 5(a)), whereas there was no significant correlation between serum sST2 and the levels of IL-2, IL-4, IL-17A, and IFN-γ in IgAN patients (Figures 5(b)–5(e)).

View Article: PubMed Central - PubMed

ABSTRACT

Background. The IL-33/ST2 axis is involved in humoral immune responses. Method. The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA. Clinical and laboratory data were examined. The potential association between sera IL-33 and sST2 and the clinical parameters in IgAN patients were analyzed. Results. No difference was discovered in IL-33 concentrations between IgAN patients and HCs; however, the sST2 were significantly higher in each stage of IgAN progression than in the HC. The concentration of sST2 was positively correlated with IL-33 levels in IgAN patients. Higher levels of sera IL-2, IL-4, IL-10, IL-17A, and IFN-γ were detected in patients compared to the HC. The concentration of serum sST2 was positively correlated with the levels of IL-10 in IgAN patients. Furthermore, serum sST2 was negatively correlated with the values of eGFR and serum calcium. Serum sST2 was positively correlated with 24-hour urinary protein, serum phosphorus, and serum IgA; however, serum IL-33 was not associated with these. Following treatment, serum sST2 was significantly decreased, while sera IL-4 and IL-10 were significantly increased. Conclusions. Increased sST2 and IL-10 but not IL-33 may be involved in the pathogenic process of IgAN.

No MeSH data available.