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Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy

View Article: PubMed Central - PubMed

ABSTRACT

Background. The IL-33/ST2 axis is involved in humoral immune responses. Method. The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA. Clinical and laboratory data were examined. The potential association between sera IL-33 and sST2 and the clinical parameters in IgAN patients were analyzed. Results. No difference was discovered in IL-33 concentrations between IgAN patients and HCs; however, the sST2 were significantly higher in each stage of IgAN progression than in the HC. The concentration of sST2 was positively correlated with IL-33 levels in IgAN patients. Higher levels of sera IL-2, IL-4, IL-10, IL-17A, and IFN-γ were detected in patients compared to the HC. The concentration of serum sST2 was positively correlated with the levels of IL-10 in IgAN patients. Furthermore, serum sST2 was negatively correlated with the values of eGFR and serum calcium. Serum sST2 was positively correlated with 24-hour urinary protein, serum phosphorus, and serum IgA; however, serum IL-33 was not associated with these. Following treatment, serum sST2 was significantly decreased, while sera IL-4 and IL-10 were significantly increased. Conclusions. Increased sST2 and IL-10 but not IL-33 may be involved in the pathogenic process of IgAN.

No MeSH data available.


Correlation analysis of serum sST2 with the values of clinical parameters in IgAN patients. The potential correlations between serum sST2 and the values of clinical parameters were analyzed by Spearman correlation tests. Data shown are the mean concentration of individual subjects from two separate experiments. (a) Serum sST2 levels were correlated negatively with the values of eGFR. (b) Serum sST2 levels were correlated positively with the concentrations of 24-hour urinary proteins. (c) Serum sST2 levels were correlated negatively with serum calcium. ((d)-(e)) Serum sST2 levels were correlated positively with serum phosphorus and serum IgA, respectively.
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fig3: Correlation analysis of serum sST2 with the values of clinical parameters in IgAN patients. The potential correlations between serum sST2 and the values of clinical parameters were analyzed by Spearman correlation tests. Data shown are the mean concentration of individual subjects from two separate experiments. (a) Serum sST2 levels were correlated negatively with the values of eGFR. (b) Serum sST2 levels were correlated positively with the concentrations of 24-hour urinary proteins. (c) Serum sST2 levels were correlated negatively with serum calcium. ((d)-(e)) Serum sST2 levels were correlated positively with serum phosphorus and serum IgA, respectively.

Mentions: To understand the importance of sST2 in the pathogenesis of IgAN, we analyzed the potential relationship of serum sST2 with the values of clinical measures detected in these patients. We found that the serum sST2 levels were correlated negatively with the values of eGFR (r = −0.4527, p = 0.0021, Figure 3(a)) and serum calcium (r = −0.4196, p = 0.0008, Figure 3(c)); however, they correlated positively with the concentrations of 24-hour urinary proteins (r = 0.5125, p = 0.0005, Figure 3(b)), serum phosphorus (r = 0.4028, p = 0.0014, Figure 3(d)), and serum IgA (r = 0.5439, p = 0.0002, Figure 3(e)) in these patients. No obvious correlation was found between clinical index and IL-2, IL-4, IL-10, IL-17A, IFN-γ, and IL-33 levels (data not shown). Together, this data suggests that sST2 may participate in the mechanism of IgAN and play an important role in the disorder of bone pathogenesis in IgAN patients.


Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy
Correlation analysis of serum sST2 with the values of clinical parameters in IgAN patients. The potential correlations between serum sST2 and the values of clinical parameters were analyzed by Spearman correlation tests. Data shown are the mean concentration of individual subjects from two separate experiments. (a) Serum sST2 levels were correlated negatively with the values of eGFR. (b) Serum sST2 levels were correlated positively with the concentrations of 24-hour urinary proteins. (c) Serum sST2 levels were correlated negatively with serum calcium. ((d)-(e)) Serum sST2 levels were correlated positively with serum phosphorus and serum IgA, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5120178&req=5

fig3: Correlation analysis of serum sST2 with the values of clinical parameters in IgAN patients. The potential correlations between serum sST2 and the values of clinical parameters were analyzed by Spearman correlation tests. Data shown are the mean concentration of individual subjects from two separate experiments. (a) Serum sST2 levels were correlated negatively with the values of eGFR. (b) Serum sST2 levels were correlated positively with the concentrations of 24-hour urinary proteins. (c) Serum sST2 levels were correlated negatively with serum calcium. ((d)-(e)) Serum sST2 levels were correlated positively with serum phosphorus and serum IgA, respectively.
Mentions: To understand the importance of sST2 in the pathogenesis of IgAN, we analyzed the potential relationship of serum sST2 with the values of clinical measures detected in these patients. We found that the serum sST2 levels were correlated negatively with the values of eGFR (r = −0.4527, p = 0.0021, Figure 3(a)) and serum calcium (r = −0.4196, p = 0.0008, Figure 3(c)); however, they correlated positively with the concentrations of 24-hour urinary proteins (r = 0.5125, p = 0.0005, Figure 3(b)), serum phosphorus (r = 0.4028, p = 0.0014, Figure 3(d)), and serum IgA (r = 0.5439, p = 0.0002, Figure 3(e)) in these patients. No obvious correlation was found between clinical index and IL-2, IL-4, IL-10, IL-17A, IFN-γ, and IL-33 levels (data not shown). Together, this data suggests that sST2 may participate in the mechanism of IgAN and play an important role in the disorder of bone pathogenesis in IgAN patients.

View Article: PubMed Central - PubMed

ABSTRACT

Background. The IL-33/ST2 axis is involved in humoral immune responses. Method. The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA. Clinical and laboratory data were examined. The potential association between sera IL-33 and sST2 and the clinical parameters in IgAN patients were analyzed. Results. No difference was discovered in IL-33 concentrations between IgAN patients and HCs; however, the sST2 were significantly higher in each stage of IgAN progression than in the HC. The concentration of sST2 was positively correlated with IL-33 levels in IgAN patients. Higher levels of sera IL-2, IL-4, IL-10, IL-17A, and IFN-γ were detected in patients compared to the HC. The concentration of serum sST2 was positively correlated with the levels of IL-10 in IgAN patients. Furthermore, serum sST2 was negatively correlated with the values of eGFR and serum calcium. Serum sST2 was positively correlated with 24-hour urinary protein, serum phosphorus, and serum IgA; however, serum IL-33 was not associated with these. Following treatment, serum sST2 was significantly decreased, while sera IL-4 and IL-10 were significantly increased. Conclusions. Increased sST2 and IL-10 but not IL-33 may be involved in the pathogenic process of IgAN.

No MeSH data available.