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Clinical efficacy of photodynamic therapy

View Article: PubMed Central - PubMed

ABSTRACT

Objective: The management of cervical intraepithelial neoplasia (CIN) and early invasive cancer of the uterine cervix is very difficult to approach, especially in case of young woman who wants to preserve her fertility. Conization of the cervix may have various kinds of disadvantage. The objective of this clinical retrospective study is to investigate the therapeutic effects and clinical efficacy of photodynamic therapy (PDT) including combined chemo-photodynamic therapy in patients with pre-malignant CIN and malignant invasive cervical cancer.

Methods: Total number of PDT trial case was 50 cases and total number of patient was 22 patients who registered to PDT clinic. We used photogem sensitizer and 632 nm diode laser in early two cases. After then we performed PDT using photofrin sensitizer and 630 nm diode laser in other cases. We used flat-cut, microlens, cylindrical diffuser, and interstitial type optic fibers in order to irradiate the lesions. 240 J/cm2 energy was irradiated to the lesions.

Results: CIN 2 were 4 cases (18.2%) and CIN 3 were 15 (68.2%) and invasive cervical cancer were 3 (13.6%). Complete remission (CR) was found in 20 patients (91%). One case of 19 patients with CIN lesion recurred at 18 months after PDT treatment. CR was found in 18 cases in the patients with CIN lesions (95%). CR was found in 2 cases in the patients with invasive cervical cancer (67%).

Conclusion: Our data showed that CR rate was fantastic in CIN group (95%). This study suggests that PDT can be recommended as new optimistic management modality on the patients with pre-malignant CIN lesions including carcinoma in situ and relatively early invasive cancer of the uterine cervix. Combined chemo-photodynamic therapy is essential in case of invasive cervical cancer. For the young age group who desperately want to preserve their fertility and have a healthy baby, PDT can be a beacon of hope.

No MeSH data available.


Related in: MedlinePlus

The pre-combined chemo-photodynamic therapy (CCPDT) cervicographic figures of the cervix in a 30-year-old cohabited woman (para 0-0-0-0) with invasive barrel-shaped endocervical cancer (FIGO [International Federation of Gynecology and Obstetrics] stage 1B1) showed acetowhitening and slightly bulging lesions with partly bloody increased vessels in all around the exocervix (A). The post-CCPDT cervicographic figures at 62 months after 1st CCPDT shows also normal and beautiful appearance. Pap cytology was negative and human papillomavirus DNA test was negative (B).
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Figure 5: The pre-combined chemo-photodynamic therapy (CCPDT) cervicographic figures of the cervix in a 30-year-old cohabited woman (para 0-0-0-0) with invasive barrel-shaped endocervical cancer (FIGO [International Federation of Gynecology and Obstetrics] stage 1B1) showed acetowhitening and slightly bulging lesions with partly bloody increased vessels in all around the exocervix (A). The post-CCPDT cervicographic figures at 62 months after 1st CCPDT shows also normal and beautiful appearance. Pap cytology was negative and human papillomavirus DNA test was negative (B).

Mentions: In CCPDT, at 45 hours after sensitizer injection, carboplatin 75 mg/m2 was administered. At 48 hours after sensitizer injection PDT was performed. PDT or CCPDT were repeated on 2 days after the 1st PDT or CCPDT. The 2nd cycles of CCPDT were performed at 1 or 2 months after the 1st cycle of CCPDT according to the condition of the cervix in case of the patients with invasive cervical cancer (Fig. 5).


Clinical efficacy of photodynamic therapy
The pre-combined chemo-photodynamic therapy (CCPDT) cervicographic figures of the cervix in a 30-year-old cohabited woman (para 0-0-0-0) with invasive barrel-shaped endocervical cancer (FIGO [International Federation of Gynecology and Obstetrics] stage 1B1) showed acetowhitening and slightly bulging lesions with partly bloody increased vessels in all around the exocervix (A). The post-CCPDT cervicographic figures at 62 months after 1st CCPDT shows also normal and beautiful appearance. Pap cytology was negative and human papillomavirus DNA test was negative (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120067&req=5

Figure 5: The pre-combined chemo-photodynamic therapy (CCPDT) cervicographic figures of the cervix in a 30-year-old cohabited woman (para 0-0-0-0) with invasive barrel-shaped endocervical cancer (FIGO [International Federation of Gynecology and Obstetrics] stage 1B1) showed acetowhitening and slightly bulging lesions with partly bloody increased vessels in all around the exocervix (A). The post-CCPDT cervicographic figures at 62 months after 1st CCPDT shows also normal and beautiful appearance. Pap cytology was negative and human papillomavirus DNA test was negative (B).
Mentions: In CCPDT, at 45 hours after sensitizer injection, carboplatin 75 mg/m2 was administered. At 48 hours after sensitizer injection PDT was performed. PDT or CCPDT were repeated on 2 days after the 1st PDT or CCPDT. The 2nd cycles of CCPDT were performed at 1 or 2 months after the 1st cycle of CCPDT according to the condition of the cervix in case of the patients with invasive cervical cancer (Fig. 5).

View Article: PubMed Central - PubMed

ABSTRACT

Objective: The management of cervical intraepithelial neoplasia (CIN) and early invasive cancer of the uterine cervix is very difficult to approach, especially in case of young woman who wants to preserve her fertility. Conization of the cervix may have various kinds of disadvantage. The objective of this clinical retrospective study is to investigate the therapeutic effects and clinical efficacy of photodynamic therapy (PDT) including combined chemo-photodynamic therapy in patients with pre-malignant CIN and malignant invasive cervical cancer.

Methods: Total number of PDT trial case was 50 cases and total number of patient was 22 patients who registered to PDT clinic. We used photogem sensitizer and 632 nm diode laser in early two cases. After then we performed PDT using photofrin sensitizer and 630 nm diode laser in other cases. We used flat-cut, microlens, cylindrical diffuser, and interstitial type optic fibers in order to irradiate the lesions. 240 J/cm2 energy was irradiated to the lesions.

Results: CIN 2 were 4 cases (18.2%) and CIN 3 were 15 (68.2%) and invasive cervical cancer were 3 (13.6%). Complete remission (CR) was found in 20 patients (91%). One case of 19 patients with CIN lesion recurred at 18 months after PDT treatment. CR was found in 18 cases in the patients with CIN lesions (95%). CR was found in 2 cases in the patients with invasive cervical cancer (67%).

Conclusion: Our data showed that CR rate was fantastic in CIN group (95%). This study suggests that PDT can be recommended as new optimistic management modality on the patients with pre-malignant CIN lesions including carcinoma in situ and relatively early invasive cancer of the uterine cervix. Combined chemo-photodynamic therapy is essential in case of invasive cervical cancer. For the young age group who desperately want to preserve their fertility and have a healthy baby, PDT can be a beacon of hope.

No MeSH data available.


Related in: MedlinePlus