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Clinical efficacy of photodynamic therapy

View Article: PubMed Central - PubMed

ABSTRACT

Objective: The management of cervical intraepithelial neoplasia (CIN) and early invasive cancer of the uterine cervix is very difficult to approach, especially in case of young woman who wants to preserve her fertility. Conization of the cervix may have various kinds of disadvantage. The objective of this clinical retrospective study is to investigate the therapeutic effects and clinical efficacy of photodynamic therapy (PDT) including combined chemo-photodynamic therapy in patients with pre-malignant CIN and malignant invasive cervical cancer.

Methods: Total number of PDT trial case was 50 cases and total number of patient was 22 patients who registered to PDT clinic. We used photogem sensitizer and 632 nm diode laser in early two cases. After then we performed PDT using photofrin sensitizer and 630 nm diode laser in other cases. We used flat-cut, microlens, cylindrical diffuser, and interstitial type optic fibers in order to irradiate the lesions. 240 J/cm2 energy was irradiated to the lesions.

Results: CIN 2 were 4 cases (18.2%) and CIN 3 were 15 (68.2%) and invasive cervical cancer were 3 (13.6%). Complete remission (CR) was found in 20 patients (91%). One case of 19 patients with CIN lesion recurred at 18 months after PDT treatment. CR was found in 18 cases in the patients with CIN lesions (95%). CR was found in 2 cases in the patients with invasive cervical cancer (67%).

Conclusion: Our data showed that CR rate was fantastic in CIN group (95%). This study suggests that PDT can be recommended as new optimistic management modality on the patients with pre-malignant CIN lesions including carcinoma in situ and relatively early invasive cancer of the uterine cervix. Combined chemo-photodynamic therapy is essential in case of invasive cervical cancer. For the young age group who desperately want to preserve their fertility and have a healthy baby, PDT can be a beacon of hope.

No MeSH data available.


Porfimer photosensitizer (A: Photofrin, Axcan Pharma Inc., Canada/USA; INMEX Corp., Seoul, Korea) and non-thermal laser device (B: Diomed 630 nm PDT laser, Diomed, Cambridge, UK; LitePharmTech Co., Seoul, Korea).
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Figure 1: Porfimer photosensitizer (A: Photofrin, Axcan Pharma Inc., Canada/USA; INMEX Corp., Seoul, Korea) and non-thermal laser device (B: Diomed 630 nm PDT laser, Diomed, Cambridge, UK; LitePharmTech Co., Seoul, Korea).

Mentions: We used photogem sensitizer and 632 nm (Biolitec, Ceralas, Germany) diode laser in early two cases. After then we performed PDT using photofrin sensitizer and 630 nm (Diomed 630 nm PDT laser; Diomed, Cambridge, UK) diode laser in other cases (Fig. 1). In admission state, photosensitizer 2.0 mg/kg was injected intravenously in a dark room. At 48 hours after injection, PDT was performed in lithotomy position, under general anesthesia.


Clinical efficacy of photodynamic therapy
Porfimer photosensitizer (A: Photofrin, Axcan Pharma Inc., Canada/USA; INMEX Corp., Seoul, Korea) and non-thermal laser device (B: Diomed 630 nm PDT laser, Diomed, Cambridge, UK; LitePharmTech Co., Seoul, Korea).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120067&req=5

Figure 1: Porfimer photosensitizer (A: Photofrin, Axcan Pharma Inc., Canada/USA; INMEX Corp., Seoul, Korea) and non-thermal laser device (B: Diomed 630 nm PDT laser, Diomed, Cambridge, UK; LitePharmTech Co., Seoul, Korea).
Mentions: We used photogem sensitizer and 632 nm (Biolitec, Ceralas, Germany) diode laser in early two cases. After then we performed PDT using photofrin sensitizer and 630 nm (Diomed 630 nm PDT laser; Diomed, Cambridge, UK) diode laser in other cases (Fig. 1). In admission state, photosensitizer 2.0 mg/kg was injected intravenously in a dark room. At 48 hours after injection, PDT was performed in lithotomy position, under general anesthesia.

View Article: PubMed Central - PubMed

ABSTRACT

Objective: The management of cervical intraepithelial neoplasia (CIN) and early invasive cancer of the uterine cervix is very difficult to approach, especially in case of young woman who wants to preserve her fertility. Conization of the cervix may have various kinds of disadvantage. The objective of this clinical retrospective study is to investigate the therapeutic effects and clinical efficacy of photodynamic therapy (PDT) including combined chemo-photodynamic therapy in patients with pre-malignant CIN and malignant invasive cervical cancer.

Methods: Total number of PDT trial case was 50 cases and total number of patient was 22 patients who registered to PDT clinic. We used photogem sensitizer and 632 nm diode laser in early two cases. After then we performed PDT using photofrin sensitizer and 630 nm diode laser in other cases. We used flat-cut, microlens, cylindrical diffuser, and interstitial type optic fibers in order to irradiate the lesions. 240 J/cm2 energy was irradiated to the lesions.

Results: CIN 2 were 4 cases (18.2%) and CIN 3 were 15 (68.2%) and invasive cervical cancer were 3 (13.6%). Complete remission (CR) was found in 20 patients (91%). One case of 19 patients with CIN lesion recurred at 18 months after PDT treatment. CR was found in 18 cases in the patients with CIN lesions (95%). CR was found in 2 cases in the patients with invasive cervical cancer (67%).

Conclusion: Our data showed that CR rate was fantastic in CIN group (95%). This study suggests that PDT can be recommended as new optimistic management modality on the patients with pre-malignant CIN lesions including carcinoma in situ and relatively early invasive cancer of the uterine cervix. Combined chemo-photodynamic therapy is essential in case of invasive cervical cancer. For the young age group who desperately want to preserve their fertility and have a healthy baby, PDT can be a beacon of hope.

No MeSH data available.