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CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events

View Article: PubMed Central - PubMed

ABSTRACT

Background: CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 are linked to the extent of coronary artery disease (CAD) and prognostic for primary events during follow-up.

Methods: We measured CCL3-5-18 serum concentrations in 712 patients with chest discomfort referred for cardiac CT angiography. Obstructive CAD was defined as ≥50 % stenosis. The extent of CAD was measured by calcium score and segment involvement score (number of coronary segments with any CAD, range 0–16). Patients were followed up for all-cause mortality, ACS and revascularisation, for a mean 26 ± 7 months.

Results: Patients with obstructive CAD had significantly higher CCL5 (p = 0.02), and borderline significantly elevated CCL18 plasma levels as compared with patients with <50 % stenosis (p = 0.06). CCL18 levels were associated with coronary calcification (p = 0.002) and segment involvement score (p = 0.007). Corrected for traditional risk factors, only CCL5 provided independent predictive value for obstructive CAD: odds ratio (OR) 1.27 (1.02–1.59), p = 0.04. CCL5 provided independent predictive value for primary events during follow-up: OR 1.62 (1.03–2.57), p = 0.04.

Conclusions: While CCL18 serum levels correlated with extent of CAD, CCL5 demonstrated an independent association with the presence of obstructive CAD, and occurrence of primary cardiac events.

No MeSH data available.


Median concentrations of CCL3, CCL5 and CCL18
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Fig1: Median concentrations of CCL3, CCL5 and CCL18

Mentions: The mean age of the study population was 56 ± 11 years, 398 (56 %) were males. The indication for CCTA was typical chest pain in 88 (12 %), atypical in 310 (44 %) and non-anginal complaints in 314 (44 %). The mean radiation dose was 5.6 ± 4.5 mSv. The median concentration of CCL3 was 2.7 (0.0–7.0) pg/ml, for CCL5 it was 3614 (1547–8360) pg/ml and for CCL18 it was 78,553 (45,906–126,716) pg/ml (Fig. 1). Baseline characteristics are further described in Table 1.Table 1


CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events
Median concentrations of CCL3, CCL5 and CCL18
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5120005&req=5

Fig1: Median concentrations of CCL3, CCL5 and CCL18
Mentions: The mean age of the study population was 56 ± 11 years, 398 (56 %) were males. The indication for CCTA was typical chest pain in 88 (12 %), atypical in 310 (44 %) and non-anginal complaints in 314 (44 %). The mean radiation dose was 5.6 ± 4.5 mSv. The median concentration of CCL3 was 2.7 (0.0–7.0) pg/ml, for CCL5 it was 3614 (1547–8360) pg/ml and for CCL18 it was 78,553 (45,906–126,716) pg/ml (Fig. 1). Baseline characteristics are further described in Table 1.Table 1

View Article: PubMed Central - PubMed

ABSTRACT

Background: CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 are linked to the extent of coronary artery disease (CAD) and prognostic for primary events during follow-up.

Methods: We measured CCL3-5-18 serum concentrations in 712 patients with chest discomfort referred for cardiac CT angiography. Obstructive CAD was defined as ≥50 % stenosis. The extent of CAD was measured by calcium score and segment involvement score (number of coronary segments with any CAD, range 0–16). Patients were followed up for all-cause mortality, ACS and revascularisation, for a mean 26 ± 7 months.

Results: Patients with obstructive CAD had significantly higher CCL5 (p = 0.02), and borderline significantly elevated CCL18 plasma levels as compared with patients with <50 % stenosis (p = 0.06). CCL18 levels were associated with coronary calcification (p = 0.002) and segment involvement score (p = 0.007). Corrected for traditional risk factors, only CCL5 provided independent predictive value for obstructive CAD: odds ratio (OR) 1.27 (1.02–1.59), p = 0.04. CCL5 provided independent predictive value for primary events during follow-up: OR 1.62 (1.03–2.57), p = 0.04.

Conclusions: While CCL18 serum levels correlated with extent of CAD, CCL5 demonstrated an independent association with the presence of obstructive CAD, and occurrence of primary cardiac events.

No MeSH data available.