Limits...
Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses

View Article: PubMed Central - PubMed

ABSTRACT

Sanguinaria canadensis, also known as bloodroot, is a traditional medicine used by Native Americans to treat a diverse range of clinical conditions. The plants rhizome contains several alkaloids that individually target multiple molecular processes. These bioactive compounds, mechanistically correlate with the plant’s history of ethnobotanical use. Despite their identification over 50 years ago, the alkaloids of S. canadensis have not been developed into successful therapeutic agents. Instead, they have been associated with clinical toxicities ranging from mouthwash induced leukoplakia to cancer salve necrosis and treatment failure. This review explores the historical use of S. canadensis, the molecular actions of the benzophenanthridine and protopin alkaloids it contains, and explores natural alkaloid variation as a possible rationale for the inconsistent efficacy and toxicities encountered by S.canadensis therapies. Current veterinary and medicinal uses of the plant are studied with an assessment of obstacles to the pharmaceutical development of S. canadensis alkaloid based therapeutics.

No MeSH data available.


Average annual Sanguinarine concentrations in S. canadensis [90].
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC5037693&req=5

ijms-17-01414-f002: Average annual Sanguinarine concentrations in S. canadensis [90].

Mentions: The distribution of sanguinarine in different S. canadensis tissues is shown in Figure 2 [90]. Sanguinarine has its greatest concentration in the plants rhizome, followed by the roots, with minimal concentrations present in the leaves and flowers. The distribution of other alkaloids within S. canadensis is currently not documented.


Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses
Average annual Sanguinarine concentrations in S. canadensis [90].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037693&req=5

ijms-17-01414-f002: Average annual Sanguinarine concentrations in S. canadensis [90].
Mentions: The distribution of sanguinarine in different S. canadensis tissues is shown in Figure 2 [90]. Sanguinarine has its greatest concentration in the plants rhizome, followed by the roots, with minimal concentrations present in the leaves and flowers. The distribution of other alkaloids within S. canadensis is currently not documented.

View Article: PubMed Central - PubMed

ABSTRACT

Sanguinaria canadensis, also known as bloodroot, is a traditional medicine used by Native Americans to treat a diverse range of clinical conditions. The plants rhizome contains several alkaloids that individually target multiple molecular processes. These bioactive compounds, mechanistically correlate with the plant’s history of ethnobotanical use. Despite their identification over 50 years ago, the alkaloids of S. canadensis have not been developed into successful therapeutic agents. Instead, they have been associated with clinical toxicities ranging from mouthwash induced leukoplakia to cancer salve necrosis and treatment failure. This review explores the historical use of S. canadensis, the molecular actions of the benzophenanthridine and protopin alkaloids it contains, and explores natural alkaloid variation as a possible rationale for the inconsistent efficacy and toxicities encountered by S.canadensis therapies. Current veterinary and medicinal uses of the plant are studied with an assessment of obstacles to the pharmaceutical development of S. canadensis alkaloid based therapeutics.

No MeSH data available.