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Effects of Hormone Therapy on Oxidative Stress in Postmenopausal Women with Metabolic Syndrome

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ABSTRACT

The aim of this study was to determine the effect of oral hormone therapy (HT) on oxidative stress (OS) in postmenopausal women with metabolic syndrome (MetS). A randomized, double blind, placebo-controlled trial was carried out. We formed four groups of 25 women each; healthy (HW) and MetS women (MSW) were assigned to HT (1 mg/day of estradiol valerate plus 5 mg/10 day of medroxiprogesterone) or placebo. We measured plasma lipoperoxides, erythrocyte superoxide dismutase and glutathione peroxidase, total plasma antioxidant status and uric acid, as OS markers. Alternative cut-off values of each parameter were defined and a stress score (SS) ranging from 0 to 7 was used as total OS. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) criteria. Participants were seen at baseline, 3 and 6 months. After 6 months, MetS decreased in MSW-HT (48%), their triglycerides and high-density lipoprotein cholesterol (HDL-c) improved; in the other groups no difference was found. SS in MSW-HT decreased (3.8 ± 0.3 to 1.7 ± 0.3, p < 0.05) and OS was also reduced (44%), this effect was evident since 3 mo. HW-HT with high OS also decreased (40%). In placebo groups there was no change. Our findings suggest that HT improve lipids and OS associated to MetS in postmenopausal women.

No MeSH data available.


Percentage change of oxidative stress (stress score ≥4) after 3 and 6 months of treatment. Error bars are proportion standard error. McNemar chisquare test. a basal vs. 6 mo., p < 0.05; HT: hormone therapy.
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ijms-17-01388-f003: Percentage change of oxidative stress (stress score ≥4) after 3 and 6 months of treatment. Error bars are proportion standard error. McNemar chisquare test. a basal vs. 6 mo., p < 0.05; HT: hormone therapy.

Mentions: Also, the percentage of women with OS changed according to SS cut-off and was negative in both groups of women with HT; but it was more favorable in MSW when compared to healthy ones (−44% vs.−40%). In the placebo groups, the OS diminished at month 3, returning to almost the basal proportion in both (Figure 3).


Effects of Hormone Therapy on Oxidative Stress in Postmenopausal Women with Metabolic Syndrome
Percentage change of oxidative stress (stress score ≥4) after 3 and 6 months of treatment. Error bars are proportion standard error. McNemar chisquare test. a basal vs. 6 mo., p < 0.05; HT: hormone therapy.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037668&req=5

ijms-17-01388-f003: Percentage change of oxidative stress (stress score ≥4) after 3 and 6 months of treatment. Error bars are proportion standard error. McNemar chisquare test. a basal vs. 6 mo., p < 0.05; HT: hormone therapy.
Mentions: Also, the percentage of women with OS changed according to SS cut-off and was negative in both groups of women with HT; but it was more favorable in MSW when compared to healthy ones (−44% vs.−40%). In the placebo groups, the OS diminished at month 3, returning to almost the basal proportion in both (Figure 3).

View Article: PubMed Central - PubMed

ABSTRACT

The aim of this study was to determine the effect of oral hormone therapy (HT) on oxidative stress (OS) in postmenopausal women with metabolic syndrome (MetS). A randomized, double blind, placebo-controlled trial was carried out. We formed four groups of 25 women each; healthy (HW) and MetS women (MSW) were assigned to HT (1 mg/day of estradiol valerate plus 5 mg/10 day of medroxiprogesterone) or placebo. We measured plasma lipoperoxides, erythrocyte superoxide dismutase and glutathione peroxidase, total plasma antioxidant status and uric acid, as OS markers. Alternative cut-off values of each parameter were defined and a stress score (SS) ranging from 0 to 7 was used as total OS. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) criteria. Participants were seen at baseline, 3 and 6 months. After 6 months, MetS decreased in MSW-HT (48%), their triglycerides and high-density lipoprotein cholesterol (HDL-c) improved; in the other groups no difference was found. SS in MSW-HT decreased (3.8 &plusmn; 0.3 to 1.7 &plusmn; 0.3, p &lt; 0.05) and OS was also reduced (44%), this effect was evident since 3 mo. HW-HT with high OS also decreased (40%). In placebo groups there was no change. Our findings suggest that HT improve lipids and OS associated to MetS in postmenopausal women.

No MeSH data available.