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Acute kidney injury 2016: diagnosis and diagnostic workup

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ABSTRACT

Acute kidney injury (AKI) is common and is associated with serious short- and long-term complications. Early diagnosis and identification of the underlying aetiology are essential to guide management. In this review, we outline the current definition of AKI and the potential pitfalls, and summarise the existing and future tools to investigate AKI in critically ill patients.

No MeSH data available.


Generation and clearance of creatinine. Arg arginine, Glyc glycine
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Fig1: Generation and clearance of creatinine. Arg arginine, Glyc glycine

Mentions: Serum creatinine is a metabolite of creatine, a molecule that is synthesized from the amino acids glycine and arginine in liver, pancreas, and kidneys and that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle (Fig. 1). Creatinine production is determined by the amount of creatine generated in liver, pancreas, and kidneys, creatine ingested (i.e. intake of red meat) and muscle function. With a molecular weight of 113 Da, creatinine is freely filtered  by the glomeruli. In health, it is produced at a constant rate and the rate of production is matched by the rate of renal excretion. However, large and sustained falls in production have been demonstrated during critical illness [16–18].Fig. 1


Acute kidney injury 2016: diagnosis and diagnostic workup
Generation and clearance of creatinine. Arg arginine, Glyc glycine
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5037640&req=5

Fig1: Generation and clearance of creatinine. Arg arginine, Glyc glycine
Mentions: Serum creatinine is a metabolite of creatine, a molecule that is synthesized from the amino acids glycine and arginine in liver, pancreas, and kidneys and that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle (Fig. 1). Creatinine production is determined by the amount of creatine generated in liver, pancreas, and kidneys, creatine ingested (i.e. intake of red meat) and muscle function. With a molecular weight of 113 Da, creatinine is freely filtered  by the glomeruli. In health, it is produced at a constant rate and the rate of production is matched by the rate of renal excretion. However, large and sustained falls in production have been demonstrated during critical illness [16–18].Fig. 1

View Article: PubMed Central - PubMed

ABSTRACT

Acute kidney injury (AKI) is common and is associated with serious short- and long-term complications. Early diagnosis and identification of the underlying aetiology are essential to guide management. In this review, we outline the current definition of AKI and the potential pitfalls, and summarise the existing and future tools to investigate AKI in critically ill patients.

No MeSH data available.