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The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway

View Article: PubMed Central - PubMed

ABSTRACT

The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involved in cell fate decision throughout development. This activity relies notably on the CSL proteins, (an acronym for CBF-1/RBPJ-κ in Homo sapiens/Mus musculus respectively, Suppressor of Hairless in Drosophila melanogaster, Lag-1 in Caenorhabditis elegans) which is the unique transcription factor and DNA binding protein involved in this pathway. The CSL proteins have the capacity to recruit activation or repression complexes according to the cellular context. The aim of this review is to describe the different co-repressor proteins that interact directly with CSL proteins to form repression complexes thereby regulating the Notch signaling pathway in animal cells to give insights into the paralogous evolution of these co-repressors in higher eumetazoans and their subsequent effects at developmental processes.

No MeSH data available.


MINT-CSL. The SHARP/MINT proteins were reported to function as negative regulators in diverse cellular contexts as members of a general transcription regulation machinery. MINT is a potent inhibitor of the NSP that uses the BTD and CTD of CSL to form a repression complex with this transcriptional factor to modify the chromatin topology at the NSP dependent genes
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Fig5: MINT-CSL. The SHARP/MINT proteins were reported to function as negative regulators in diverse cellular contexts as members of a general transcription regulation machinery. MINT is a potent inhibitor of the NSP that uses the BTD and CTD of CSL to form a repression complex with this transcriptional factor to modify the chromatin topology at the NSP dependent genes

Mentions: MINT protein, originally described in M. musculus, presents multiple domains that promote interactions with different transcriptional factors [86, 90]. VanderWielen et al. [82] showed that MINT interacts, via its CID (CSL interacting domain, 2776-2833 aa. (Figure 5), with the BTD and CTD of CSL [82]. In vivo, MINT inhibits NSP during embryo development in the course of cellular specialization during liver, heart, pancreas formation. MINT also regulates the correct differentiation and distribution of lymphocytes. Accordingly, MINT’s inhibition is lethal for mouse embryos [86].Fig. 5


The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway
MINT-CSL. The SHARP/MINT proteins were reported to function as negative regulators in diverse cellular contexts as members of a general transcription regulation machinery. MINT is a potent inhibitor of the NSP that uses the BTD and CTD of CSL to form a repression complex with this transcriptional factor to modify the chromatin topology at the NSP dependent genes
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5037638&req=5

Fig5: MINT-CSL. The SHARP/MINT proteins were reported to function as negative regulators in diverse cellular contexts as members of a general transcription regulation machinery. MINT is a potent inhibitor of the NSP that uses the BTD and CTD of CSL to form a repression complex with this transcriptional factor to modify the chromatin topology at the NSP dependent genes
Mentions: MINT protein, originally described in M. musculus, presents multiple domains that promote interactions with different transcriptional factors [86, 90]. VanderWielen et al. [82] showed that MINT interacts, via its CID (CSL interacting domain, 2776-2833 aa. (Figure 5), with the BTD and CTD of CSL [82]. In vivo, MINT inhibits NSP during embryo development in the course of cellular specialization during liver, heart, pancreas formation. MINT also regulates the correct differentiation and distribution of lymphocytes. Accordingly, MINT’s inhibition is lethal for mouse embryos [86].Fig. 5

View Article: PubMed Central - PubMed

ABSTRACT

The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involved in cell fate decision throughout development. This activity relies notably on the CSL proteins, (an acronym for CBF-1/RBPJ-κ in Homo sapiens/Mus musculus respectively, Suppressor of Hairless in Drosophila melanogaster, Lag-1 in Caenorhabditis elegans) which is the unique transcription factor and DNA binding protein involved in this pathway. The CSL proteins have the capacity to recruit activation or repression complexes according to the cellular context. The aim of this review is to describe the different co-repressor proteins that interact directly with CSL proteins to form repression complexes thereby regulating the Notch signaling pathway in animal cells to give insights into the paralogous evolution of these co-repressors in higher eumetazoans and their subsequent effects at developmental processes.

No MeSH data available.