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The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway

View Article: PubMed Central - PubMed

ABSTRACT

The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involved in cell fate decision throughout development. This activity relies notably on the CSL proteins, (an acronym for CBF-1/RBPJ-κ in Homo sapiens/Mus musculus respectively, Suppressor of Hairless in Drosophila melanogaster, Lag-1 in Caenorhabditis elegans) which is the unique transcription factor and DNA binding protein involved in this pathway. The CSL proteins have the capacity to recruit activation or repression complexes according to the cellular context. The aim of this review is to describe the different co-repressor proteins that interact directly with CSL proteins to form repression complexes thereby regulating the Notch signaling pathway in animal cells to give insights into the paralogous evolution of these co-repressors in higher eumetazoans and their subsequent effects at developmental processes.

No MeSH data available.


The CSL proteins: CSL proteins are transcription factors regulating the Notch pathway in a positive and negative fashion. CSL type transcription factors have three functional domains well characterized: N-terminal domain (NTD), beta-trefoil domain (BTD) and C-terminal domain (CTD) which are used for protein–protein or protein-DNA interactions
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Fig2: The CSL proteins: CSL proteins are transcription factors regulating the Notch pathway in a positive and negative fashion. CSL type transcription factors have three functional domains well characterized: N-terminal domain (NTD), beta-trefoil domain (BTD) and C-terminal domain (CTD) which are used for protein–protein or protein-DNA interactions

Mentions: Briefly NSP works as follows (Fig. 1): once a protein of the DSL family (Delta/Serrate in Drosophila melanogaster; LAG-2 in Caenorhabditis elegans; Dll-1-4/Jagged in mammals) in the signal sending cell contacts the receptor, a protein of the Notch family (Notch, D. melanogaster and mammals; Lin-12/Glp-1, C. elegans) in the signal receiving cell, the NSP is activated by proteolysis of the Notch receptor. This proteolysis process releases the Notch intracellular domain (NICD) from the cell membrane [7, 12, 13]. NICD is translocated to the cell nucleus where, together with CSL proteins (Fig. 2), a fully functional transcription activation complex is assembled, including other co-activator factors such as Mastermind protein (Mam, D. melanogaster; LAG-3, C. elegans; MAML, mammals) [13–15], SKIP [16] and histone acetyltransferases (HATs) [15, 17]. This complex modifies the chromatin and activates gene expression at specific loci depending on the precise cellular context [7, 18–21].Fig. 1


The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway
The CSL proteins: CSL proteins are transcription factors regulating the Notch pathway in a positive and negative fashion. CSL type transcription factors have three functional domains well characterized: N-terminal domain (NTD), beta-trefoil domain (BTD) and C-terminal domain (CTD) which are used for protein–protein or protein-DNA interactions
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5037638&req=5

Fig2: The CSL proteins: CSL proteins are transcription factors regulating the Notch pathway in a positive and negative fashion. CSL type transcription factors have three functional domains well characterized: N-terminal domain (NTD), beta-trefoil domain (BTD) and C-terminal domain (CTD) which are used for protein–protein or protein-DNA interactions
Mentions: Briefly NSP works as follows (Fig. 1): once a protein of the DSL family (Delta/Serrate in Drosophila melanogaster; LAG-2 in Caenorhabditis elegans; Dll-1-4/Jagged in mammals) in the signal sending cell contacts the receptor, a protein of the Notch family (Notch, D. melanogaster and mammals; Lin-12/Glp-1, C. elegans) in the signal receiving cell, the NSP is activated by proteolysis of the Notch receptor. This proteolysis process releases the Notch intracellular domain (NICD) from the cell membrane [7, 12, 13]. NICD is translocated to the cell nucleus where, together with CSL proteins (Fig. 2), a fully functional transcription activation complex is assembled, including other co-activator factors such as Mastermind protein (Mam, D. melanogaster; LAG-3, C. elegans; MAML, mammals) [13–15], SKIP [16] and histone acetyltransferases (HATs) [15, 17]. This complex modifies the chromatin and activates gene expression at specific loci depending on the precise cellular context [7, 18–21].Fig. 1

View Article: PubMed Central - PubMed

ABSTRACT

The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involved in cell fate decision throughout development. This activity relies notably on the CSL proteins, (an acronym for CBF-1/RBPJ-κ in Homo sapiens/Mus musculus respectively, Suppressor of Hairless in Drosophila melanogaster, Lag-1 in Caenorhabditis elegans) which is the unique transcription factor and DNA binding protein involved in this pathway. The CSL proteins have the capacity to recruit activation or repression complexes according to the cellular context. The aim of this review is to describe the different co-repressor proteins that interact directly with CSL proteins to form repression complexes thereby regulating the Notch signaling pathway in animal cells to give insights into the paralogous evolution of these co-repressors in higher eumetazoans and their subsequent effects at developmental processes.

No MeSH data available.