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Fluorouracil implants caused a diaphragmatic tumor to be misdiagnosed as liver metastasis: a case report

View Article: PubMed Central - PubMed

ABSTRACT

Background: Fluorouracil implants are widely used in peritoneal interstitial chemotherapy. Curative effects have been obtained, but implants have also caused some complications.

Case presentation: We performed an analysis of a 66-year-old male patient’s case history, as well as conventional pathological analysis and Raman spectroscopic detection of the diaphragmatic tumor. We also analyzed the underlying causes of this condition to prevent complications and reduce misdiagnoses in future cases. The patient had a history of peritoneal fluorouracil implantation. Pathological analysis of the diaphragmatic mass revealed foreign particles, and Raman detection showed that the mass contained fluorouracil.

Conclusion: Fluorouracil implants may persist due to the high concentrations of this drug used in peritoneal chemotherapy. This finding should provide guidance and improve the application of peritoneal implants. In clinical trials, and the diagnosis of liver metastasis should be based on pathological results.

No MeSH data available.


Related in: MedlinePlus

Raman spectra of fluorouracil, the diaphragmatic foreign body and Sinofuan
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Fig4: Raman spectra of fluorouracil, the diaphragmatic foreign body and Sinofuan

Mentions: The Invia confocal Raman microscope by Renishaw was used to test the remaining foreign bodies in the diaphragm. A 785-nm wavelength laser was used and focused by an objective lens with 50X magnification. The irradiation power was set to 1 %, and the integration time was 10 s. The collection range of the spectrum was from 500 to 3200 cm−1. Samples included the cylindrical foreign body which was embedded in pathological wax blocks, Sinofuan (Wuhu harbinger of human medicine, Product lot NO.20130202), and the fluorouracil injection (HAIPU, Product lot NO.FA140506). WIRE4.0 spectral software (see Fig. 4) was used for analysis. The three spectra all showed significant peaks in the areas of 412, 687, 1344, 1538, and 2876 cm−1 of roughly the same height. Thus, it was concluded that both the cylindrical foreign body in the pathological wax blocks and Sinofuan contained fluorouracil.Fig. 4


Fluorouracil implants caused a diaphragmatic tumor to be misdiagnosed as liver metastasis: a case report
Raman spectra of fluorouracil, the diaphragmatic foreign body and Sinofuan
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5037584&req=5

Fig4: Raman spectra of fluorouracil, the diaphragmatic foreign body and Sinofuan
Mentions: The Invia confocal Raman microscope by Renishaw was used to test the remaining foreign bodies in the diaphragm. A 785-nm wavelength laser was used and focused by an objective lens with 50X magnification. The irradiation power was set to 1 %, and the integration time was 10 s. The collection range of the spectrum was from 500 to 3200 cm−1. Samples included the cylindrical foreign body which was embedded in pathological wax blocks, Sinofuan (Wuhu harbinger of human medicine, Product lot NO.20130202), and the fluorouracil injection (HAIPU, Product lot NO.FA140506). WIRE4.0 spectral software (see Fig. 4) was used for analysis. The three spectra all showed significant peaks in the areas of 412, 687, 1344, 1538, and 2876 cm−1 of roughly the same height. Thus, it was concluded that both the cylindrical foreign body in the pathological wax blocks and Sinofuan contained fluorouracil.Fig. 4

View Article: PubMed Central - PubMed

ABSTRACT

Background: Fluorouracil implants are widely used in peritoneal interstitial chemotherapy. Curative effects have been obtained, but implants have also caused some complications.

Case presentation: We performed an analysis of a 66-year-old male patient’s case history, as well as conventional pathological analysis and Raman spectroscopic detection of the diaphragmatic tumor. We also analyzed the underlying causes of this condition to prevent complications and reduce misdiagnoses in future cases. The patient had a history of peritoneal fluorouracil implantation. Pathological analysis of the diaphragmatic mass revealed foreign particles, and Raman detection showed that the mass contained fluorouracil.

Conclusion: Fluorouracil implants may persist due to the high concentrations of this drug used in peritoneal chemotherapy. This finding should provide guidance and improve the application of peritoneal implants. In clinical trials, and the diagnosis of liver metastasis should be based on pathological results.

No MeSH data available.


Related in: MedlinePlus