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The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms

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ABSTRACT

The high incidence of breast cancer in developed and developing countries, and its correlation to cancer-related deaths, has prompted concerned scientists to discover novel alternatives to deal with this challenge. In this review, we will provide a brief overview of polyphenol structures and classifications, as well as on the carcinogenic process. The biology of breast cancer cells will also be discussed. The molecular mechanisms involved in the anti-cancer activities of numerous polyphenols, against a wide range of breast cancer cells, in vitro and in vivo, will be explained in detail. The interplay between autophagy and apoptosis in the anti-cancer activity of polyphenols will also be highlighted. In addition, the potential of polyphenols to target cancer stem cells (CSCs) via various mechanisms will be explained. Recently, the use of natural products as chemotherapeutics and chemopreventive drugs to overcome the side effects and resistance that arise from using chemical-based agents has garnered the attention of the scientific community. Polyphenol research is considered a promising field in the treatment and prevention of breast cancer.

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Related in: MedlinePlus

Comprehensive representation summarizing the possible mechanisms of action of polyphenols against breast cancer. The anti-cancer activity of polyphenols is mediated via the regulation of various signaling pathways, such as intrinsic and extrinsic apoptotic pathways, estrogen-related signaling pathways, cell cycle arrest, and inflammation-related signaling pathways. RES, resveratrol; CUR, curcumin; GENI, genistein; QUR, quercetin; APIG, apigenin.
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nutrients-08-00581-f005: Comprehensive representation summarizing the possible mechanisms of action of polyphenols against breast cancer. The anti-cancer activity of polyphenols is mediated via the regulation of various signaling pathways, such as intrinsic and extrinsic apoptotic pathways, estrogen-related signaling pathways, cell cycle arrest, and inflammation-related signaling pathways. RES, resveratrol; CUR, curcumin; GENI, genistein; QUR, quercetin; APIG, apigenin.

Mentions: The anti-cancer activities of polyphenols against a wide range of cancers, such as breast cancer [173], prostate cancer [174], colorectal cancer [175], pancreatic cancer, lung cancer, colorectal fibrosarcoma, and leukemia, have been proven [176]. The possible mechanisms underlying the anticancer activity of polyphenols against breast cancer are summarized in Figure 5, and the possible molecular mechanisms by which polyphenols kill breast cancer are described below.


The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms
Comprehensive representation summarizing the possible mechanisms of action of polyphenols against breast cancer. The anti-cancer activity of polyphenols is mediated via the regulation of various signaling pathways, such as intrinsic and extrinsic apoptotic pathways, estrogen-related signaling pathways, cell cycle arrest, and inflammation-related signaling pathways. RES, resveratrol; CUR, curcumin; GENI, genistein; QUR, quercetin; APIG, apigenin.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037565&req=5

nutrients-08-00581-f005: Comprehensive representation summarizing the possible mechanisms of action of polyphenols against breast cancer. The anti-cancer activity of polyphenols is mediated via the regulation of various signaling pathways, such as intrinsic and extrinsic apoptotic pathways, estrogen-related signaling pathways, cell cycle arrest, and inflammation-related signaling pathways. RES, resveratrol; CUR, curcumin; GENI, genistein; QUR, quercetin; APIG, apigenin.
Mentions: The anti-cancer activities of polyphenols against a wide range of cancers, such as breast cancer [173], prostate cancer [174], colorectal cancer [175], pancreatic cancer, lung cancer, colorectal fibrosarcoma, and leukemia, have been proven [176]. The possible mechanisms underlying the anticancer activity of polyphenols against breast cancer are summarized in Figure 5, and the possible molecular mechanisms by which polyphenols kill breast cancer are described below.

View Article: PubMed Central - PubMed

ABSTRACT

The high incidence of breast cancer in developed and developing countries, and its correlation to cancer-related deaths, has prompted concerned scientists to discover novel alternatives to deal with this challenge. In this review, we will provide a brief overview of polyphenol structures and classifications, as well as on the carcinogenic process. The biology of breast cancer cells will also be discussed. The molecular mechanisms involved in the anti-cancer activities of numerous polyphenols, against a wide range of breast cancer cells, in vitro and in vivo, will be explained in detail. The interplay between autophagy and apoptosis in the anti-cancer activity of polyphenols will also be highlighted. In addition, the potential of polyphenols to target cancer stem cells (CSCs) via various mechanisms will be explained. Recently, the use of natural products as chemotherapeutics and chemopreventive drugs to overcome the side effects and resistance that arise from using chemical-based agents has garnered the attention of the scientific community. Polyphenol research is considered a promising field in the treatment and prevention of breast cancer.

No MeSH data available.


Related in: MedlinePlus