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The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms

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ABSTRACT

The high incidence of breast cancer in developed and developing countries, and its correlation to cancer-related deaths, has prompted concerned scientists to discover novel alternatives to deal with this challenge. In this review, we will provide a brief overview of polyphenol structures and classifications, as well as on the carcinogenic process. The biology of breast cancer cells will also be discussed. The molecular mechanisms involved in the anti-cancer activities of numerous polyphenols, against a wide range of breast cancer cells, in vitro and in vivo, will be explained in detail. The interplay between autophagy and apoptosis in the anti-cancer activity of polyphenols will also be highlighted. In addition, the potential of polyphenols to target cancer stem cells (CSCs) via various mechanisms will be explained. Recently, the use of natural products as chemotherapeutics and chemopreventive drugs to overcome the side effects and resistance that arise from using chemical-based agents has garnered the attention of the scientific community. Polyphenol research is considered a promising field in the treatment and prevention of breast cancer.

No MeSH data available.


Related in: MedlinePlus

Role of polyphenols in the modulation of autophagy in breast cancer. Polyphenols modulate the autophagy process by regulating various signaling pathways, such as the PI3K/AKT, RAS/RAF/ERK, PKCδ, and AMPK signaling pathways.
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nutrients-08-00581-f004: Role of polyphenols in the modulation of autophagy in breast cancer. Polyphenols modulate the autophagy process by regulating various signaling pathways, such as the PI3K/AKT, RAS/RAF/ERK, PKCδ, and AMPK signaling pathways.

Mentions: Below, we will discuss examples of polyphenols, and how autophagy signaling pathways and transcription factors are involved in their anti-cancer potentials, as summarized in Figure 4.


The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms
Role of polyphenols in the modulation of autophagy in breast cancer. Polyphenols modulate the autophagy process by regulating various signaling pathways, such as the PI3K/AKT, RAS/RAF/ERK, PKCδ, and AMPK signaling pathways.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037565&req=5

nutrients-08-00581-f004: Role of polyphenols in the modulation of autophagy in breast cancer. Polyphenols modulate the autophagy process by regulating various signaling pathways, such as the PI3K/AKT, RAS/RAF/ERK, PKCδ, and AMPK signaling pathways.
Mentions: Below, we will discuss examples of polyphenols, and how autophagy signaling pathways and transcription factors are involved in their anti-cancer potentials, as summarized in Figure 4.

View Article: PubMed Central - PubMed

ABSTRACT

The high incidence of breast cancer in developed and developing countries, and its correlation to cancer-related deaths, has prompted concerned scientists to discover novel alternatives to deal with this challenge. In this review, we will provide a brief overview of polyphenol structures and classifications, as well as on the carcinogenic process. The biology of breast cancer cells will also be discussed. The molecular mechanisms involved in the anti-cancer activities of numerous polyphenols, against a wide range of breast cancer cells, in vitro and in vivo, will be explained in detail. The interplay between autophagy and apoptosis in the anti-cancer activity of polyphenols will also be highlighted. In addition, the potential of polyphenols to target cancer stem cells (CSCs) via various mechanisms will be explained. Recently, the use of natural products as chemotherapeutics and chemopreventive drugs to overcome the side effects and resistance that arise from using chemical-based agents has garnered the attention of the scientific community. Polyphenol research is considered a promising field in the treatment and prevention of breast cancer.

No MeSH data available.


Related in: MedlinePlus