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The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms

View Article: PubMed Central - PubMed

ABSTRACT

The high incidence of breast cancer in developed and developing countries, and its correlation to cancer-related deaths, has prompted concerned scientists to discover novel alternatives to deal with this challenge. In this review, we will provide a brief overview of polyphenol structures and classifications, as well as on the carcinogenic process. The biology of breast cancer cells will also be discussed. The molecular mechanisms involved in the anti-cancer activities of numerous polyphenols, against a wide range of breast cancer cells, in vitro and in vivo, will be explained in detail. The interplay between autophagy and apoptosis in the anti-cancer activity of polyphenols will also be highlighted. In addition, the potential of polyphenols to target cancer stem cells (CSCs) via various mechanisms will be explained. Recently, the use of natural products as chemotherapeutics and chemopreventive drugs to overcome the side effects and resistance that arise from using chemical-based agents has garnered the attention of the scientific community. Polyphenol research is considered a promising field in the treatment and prevention of breast cancer.

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Related in: MedlinePlus

Overview summarizing the main health benefits of polyphenols. Polyphenols play key roles in the prevention of serious diseases that threaten human life and negatively affect quality of life, such as cancer, metabolic diseases, neurodegenerative diseases, hypertension, and cardiac diseases.
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nutrients-08-00581-f003: Overview summarizing the main health benefits of polyphenols. Polyphenols play key roles in the prevention of serious diseases that threaten human life and negatively affect quality of life, such as cancer, metabolic diseases, neurodegenerative diseases, hypertension, and cardiac diseases.

Mentions: Polyphenols are considered the main natural antioxidant component in fruits, vegetables, tea, oils, and cereals. The wide range of health benefits of dietary polyphenols is ascribed to their potential in reducing the risk, as well as preventing, serious diseases, such as cancer, metabolic diseases, neurodegenerative diseases, and heart diseases, which threaten human life and negatively affect quality of life, as summarized in Figure 3 [85].


The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms
Overview summarizing the main health benefits of polyphenols. Polyphenols play key roles in the prevention of serious diseases that threaten human life and negatively affect quality of life, such as cancer, metabolic diseases, neurodegenerative diseases, hypertension, and cardiac diseases.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037565&req=5

nutrients-08-00581-f003: Overview summarizing the main health benefits of polyphenols. Polyphenols play key roles in the prevention of serious diseases that threaten human life and negatively affect quality of life, such as cancer, metabolic diseases, neurodegenerative diseases, hypertension, and cardiac diseases.
Mentions: Polyphenols are considered the main natural antioxidant component in fruits, vegetables, tea, oils, and cereals. The wide range of health benefits of dietary polyphenols is ascribed to their potential in reducing the risk, as well as preventing, serious diseases, such as cancer, metabolic diseases, neurodegenerative diseases, and heart diseases, which threaten human life and negatively affect quality of life, as summarized in Figure 3 [85].

View Article: PubMed Central - PubMed

ABSTRACT

The high incidence of breast cancer in developed and developing countries, and its correlation to cancer-related deaths, has prompted concerned scientists to discover novel alternatives to deal with this challenge. In this review, we will provide a brief overview of polyphenol structures and classifications, as well as on the carcinogenic process. The biology of breast cancer cells will also be discussed. The molecular mechanisms involved in the anti-cancer activities of numerous polyphenols, against a wide range of breast cancer cells, in vitro and in vivo, will be explained in detail. The interplay between autophagy and apoptosis in the anti-cancer activity of polyphenols will also be highlighted. In addition, the potential of polyphenols to target cancer stem cells (CSCs) via various mechanisms will be explained. Recently, the use of natural products as chemotherapeutics and chemopreventive drugs to overcome the side effects and resistance that arise from using chemical-based agents has garnered the attention of the scientific community. Polyphenol research is considered a promising field in the treatment and prevention of breast cancer.

No MeSH data available.


Related in: MedlinePlus