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Relationship between Vitamin D Status and Autonomic Nervous System Activity

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ABSTRACT

Vitamin D deficiency is associated with increased arterial stiffness. However, the mechanisms underlying this association have not been clarified. The aim was to investigate whether changes in autonomic nervous system activity could underlie an association between 25 hydroxy vitamin D and arterial stiffness. A total of 49 subjects (age = 60 ± 8 years, body mass index = 26.7 ± 4.6 kg/m2, 25 hydroxy vitamin D = 69 ± 22 nmol/L) underwent measurements of pulse wave velocity (PWV) and augmentation index (AIx), spontaneous baroreflex sensitivity, plasma metanephrines and 25 hydroxy vitamin D. Subjects with 25 hydroxy vitamin D ≤ 50 nmol/L were restudied after 200,000 International Units 25 hydroxy vitamin D. Plasma metanephrine was positively associated with AIx (p = 0.02) independent of age, sex, smoking and cholesterol and negatively associated with 25 hydroxy vitamin D (p = 0.002) independent of age, sex and season. In contrast, there was no association between baroreflex sensitivity and 25 hydroxy vitamin D (p = 0.54). Treatment with vitamin D increased 25 hydroxy vitamin D from 43 ± 5 to 96 ± 24 nmol/L (p < 0.0001) but there was no significant change in plasma metanephrine (115 ± 25 vs. 99 ± 39 pmol/L, p = 0.12). We conclude that as plasma metanephrine was negatively associated with 25 hydroxy vitamin D and positively with AIx, it could mediate an association between these two variables. This hypothesis should be tested in larger interventional studies.

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Simple linear regression relationship between serum 25 hydroxy vitamin D and plasma metanephrine in 43 subjects.
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nutrients-08-00565-f001: Simple linear regression relationship between serum 25 hydroxy vitamin D and plasma metanephrine in 43 subjects.

Mentions: Figure 1 depicts the univariable relationship between serum 25 hydroxy vitamin D concentration and plasma metanephrine. Plasma metanephrine was negatively associated with serum 25 hydroxy vitamin D concentration, independent of age, sex and season (Table 2). Baroreflex sensitivity, low frequency heart rate variability, high frequency heart rate variability, LF:HF ratio and plasma normetanephrine were not independently associated with serum 25 hydroxy vitamin D concentration (Table 2). The negative correlation between 25 hydroxy vitamin D and AIx, albeit similar to that reported in previous studies [6], was not statistically significant (r = −0.24, p = 0.10). 1,25 dihydroxy vitamin D and PTH were not significantly associated with measures of autonomic nervous system activity (Table 2).


Relationship between Vitamin D Status and Autonomic Nervous System Activity
Simple linear regression relationship between serum 25 hydroxy vitamin D and plasma metanephrine in 43 subjects.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037550&req=5

nutrients-08-00565-f001: Simple linear regression relationship between serum 25 hydroxy vitamin D and plasma metanephrine in 43 subjects.
Mentions: Figure 1 depicts the univariable relationship between serum 25 hydroxy vitamin D concentration and plasma metanephrine. Plasma metanephrine was negatively associated with serum 25 hydroxy vitamin D concentration, independent of age, sex and season (Table 2). Baroreflex sensitivity, low frequency heart rate variability, high frequency heart rate variability, LF:HF ratio and plasma normetanephrine were not independently associated with serum 25 hydroxy vitamin D concentration (Table 2). The negative correlation between 25 hydroxy vitamin D and AIx, albeit similar to that reported in previous studies [6], was not statistically significant (r = −0.24, p = 0.10). 1,25 dihydroxy vitamin D and PTH were not significantly associated with measures of autonomic nervous system activity (Table 2).

View Article: PubMed Central - PubMed

ABSTRACT

Vitamin D deficiency is associated with increased arterial stiffness. However, the mechanisms underlying this association have not been clarified. The aim was to investigate whether changes in autonomic nervous system activity could underlie an association between 25 hydroxy vitamin D and arterial stiffness. A total of 49 subjects (age = 60 ± 8 years, body mass index = 26.7 ± 4.6 kg/m2, 25 hydroxy vitamin D = 69 ± 22 nmol/L) underwent measurements of pulse wave velocity (PWV) and augmentation index (AIx), spontaneous baroreflex sensitivity, plasma metanephrines and 25 hydroxy vitamin D. Subjects with 25 hydroxy vitamin D ≤ 50 nmol/L were restudied after 200,000 International Units 25 hydroxy vitamin D. Plasma metanephrine was positively associated with AIx (p = 0.02) independent of age, sex, smoking and cholesterol and negatively associated with 25 hydroxy vitamin D (p = 0.002) independent of age, sex and season. In contrast, there was no association between baroreflex sensitivity and 25 hydroxy vitamin D (p = 0.54). Treatment with vitamin D increased 25 hydroxy vitamin D from 43 ± 5 to 96 ± 24 nmol/L (p < 0.0001) but there was no significant change in plasma metanephrine (115 ± 25 vs. 99 ± 39 pmol/L, p = 0.12). We conclude that as plasma metanephrine was negatively associated with 25 hydroxy vitamin D and positively with AIx, it could mediate an association between these two variables. This hypothesis should be tested in larger interventional studies.

No MeSH data available.


Related in: MedlinePlus