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Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians

View Article: PubMed Central - PubMed

ABSTRACT

The relationships between diet and metabolites as well as element profiles in healthy centenarians are important but remain inconclusive. Therefore, to test the interesting hypothesis that there would be distinctive features of metabolites and element profiles in healthy centenarians, and that these would be associated with nutrient intake; the short chain fatty acids (SCFAs), total bile acids and ammonia in feces, phenol, p-cresol, uric acid, urea, creatinine and ammonia in urine, and element profiles in fingernails were determined in 90 healthy elderly people, including centenarians from Bama county (China)—a famous longevous region—and elderly people aged 80–99 from the longevous region and a non-longevous region. The partial least squares-discriminant analysis was used for pattern recognition. As a result, the centenarians showed a distinct metabolic pattern. Seven characteristic components closely related to the centenarians were identified, including acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid. Their concentrations were significantly higher in the centenarians group (p < 0.05). Additionally, the dietary fiber intake was positively associated with butyric acid contents in feces (r = 0.896, p < 0.01), and negatively associated with phenol in urine (r = −0.326, p < 0.01). The results suggest that the specific metabolic pattern of centenarians may have an important and positive influence on the formation of the longevity phenomenon. Elevated dietary fiber intake should be a path toward health and longevity.

No MeSH data available.


Correlations between the nutrient intake and metabolites as well as element levels. Red denotes positive correlation, blue denotes negative correlation, and yellow denotes no correlation. There was a significant positive correlation between dietary fiber intake and butyric acid contents in feces, and the correlation coefficient was highest (r = 0.896, p < 0.01). The other short chain fatty acids also were positively associated with dietary fiber intake (p < 0.05). Besides, the dietary fiber intake was negatively associated with the contents of phenol in urine (r = −0.326, p < 0.01).
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nutrients-08-00564-f006: Correlations between the nutrient intake and metabolites as well as element levels. Red denotes positive correlation, blue denotes negative correlation, and yellow denotes no correlation. There was a significant positive correlation between dietary fiber intake and butyric acid contents in feces, and the correlation coefficient was highest (r = 0.896, p < 0.01). The other short chain fatty acids also were positively associated with dietary fiber intake (p < 0.05). Besides, the dietary fiber intake was negatively associated with the contents of phenol in urine (r = −0.326, p < 0.01).

Mentions: In order to assess the relationships between the nutrient intake and metabolites, as well as element levels, the Spearman correlation test was performed (Figure 6). There was a significant positive correlation between dietary fiber intake and butyric acid contents in feces, and the correlation coefficient was highest (r = 0.896, p < 0.01). The other short chain fatty acids were also positively associated with dietary fiber intake (p < 0.05). In addition, the contents of the SCFAs were also significantly associated with the intake of energy, protein, vitamin A and nicotinic acid (p < 0.05). Besides, the contents of phenol were negatively associated with the intake of dietary fiber (r = −0.326, p < 0.01). Additionally, Mn contents in fingernails were significantly associated with the intake of energy, protein, fat, dietary fiber, cholesterol, vitamin A, thiamine, nicotinic acid, sodium, magnesium, zinc and selenium (p < 0.05). Co contents in fingernails were significantly associated with the intake of energy, dietary fiber, cholesterol, vitamin A, thiamine, nicotinic acid, sodium and magnesium (p < 0.05).


Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians
Correlations between the nutrient intake and metabolites as well as element levels. Red denotes positive correlation, blue denotes negative correlation, and yellow denotes no correlation. There was a significant positive correlation between dietary fiber intake and butyric acid contents in feces, and the correlation coefficient was highest (r = 0.896, p < 0.01). The other short chain fatty acids also were positively associated with dietary fiber intake (p < 0.05). Besides, the dietary fiber intake was negatively associated with the contents of phenol in urine (r = −0.326, p < 0.01).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037549&req=5

nutrients-08-00564-f006: Correlations between the nutrient intake and metabolites as well as element levels. Red denotes positive correlation, blue denotes negative correlation, and yellow denotes no correlation. There was a significant positive correlation between dietary fiber intake and butyric acid contents in feces, and the correlation coefficient was highest (r = 0.896, p < 0.01). The other short chain fatty acids also were positively associated with dietary fiber intake (p < 0.05). Besides, the dietary fiber intake was negatively associated with the contents of phenol in urine (r = −0.326, p < 0.01).
Mentions: In order to assess the relationships between the nutrient intake and metabolites, as well as element levels, the Spearman correlation test was performed (Figure 6). There was a significant positive correlation between dietary fiber intake and butyric acid contents in feces, and the correlation coefficient was highest (r = 0.896, p < 0.01). The other short chain fatty acids were also positively associated with dietary fiber intake (p < 0.05). In addition, the contents of the SCFAs were also significantly associated with the intake of energy, protein, vitamin A and nicotinic acid (p < 0.05). Besides, the contents of phenol were negatively associated with the intake of dietary fiber (r = −0.326, p < 0.01). Additionally, Mn contents in fingernails were significantly associated with the intake of energy, protein, fat, dietary fiber, cholesterol, vitamin A, thiamine, nicotinic acid, sodium, magnesium, zinc and selenium (p < 0.05). Co contents in fingernails were significantly associated with the intake of energy, dietary fiber, cholesterol, vitamin A, thiamine, nicotinic acid, sodium and magnesium (p < 0.05).

View Article: PubMed Central - PubMed

ABSTRACT

The relationships between diet and metabolites as well as element profiles in healthy centenarians are important but remain inconclusive. Therefore, to test the interesting hypothesis that there would be distinctive features of metabolites and element profiles in healthy centenarians, and that these would be associated with nutrient intake; the short chain fatty acids (SCFAs), total bile acids and ammonia in feces, phenol, p-cresol, uric acid, urea, creatinine and ammonia in urine, and element profiles in fingernails were determined in 90 healthy elderly people, including centenarians from Bama county (China)&mdash;a famous longevous region&mdash;and elderly people aged 80&ndash;99 from the longevous region and a non-longevous region. The partial least squares-discriminant analysis was used for pattern recognition. As a result, the centenarians showed a distinct metabolic pattern. Seven characteristic components closely related to the centenarians were identified, including acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid. Their concentrations were significantly higher in the centenarians group (p &lt; 0.05). Additionally, the dietary fiber intake was positively associated with butyric acid contents in feces (r = 0.896, p &lt; 0.01), and negatively associated with phenol in urine (r = &minus;0.326, p &lt; 0.01). The results suggest that the specific metabolic pattern of centenarians may have an important and positive influence on the formation of the longevity phenomenon. Elevated dietary fiber intake should be a path toward health and longevity.

No MeSH data available.