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Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians

View Article: PubMed Central - PubMed

ABSTRACT

The relationships between diet and metabolites as well as element profiles in healthy centenarians are important but remain inconclusive. Therefore, to test the interesting hypothesis that there would be distinctive features of metabolites and element profiles in healthy centenarians, and that these would be associated with nutrient intake; the short chain fatty acids (SCFAs), total bile acids and ammonia in feces, phenol, p-cresol, uric acid, urea, creatinine and ammonia in urine, and element profiles in fingernails were determined in 90 healthy elderly people, including centenarians from Bama county (China)—a famous longevous region—and elderly people aged 80–99 from the longevous region and a non-longevous region. The partial least squares-discriminant analysis was used for pattern recognition. As a result, the centenarians showed a distinct metabolic pattern. Seven characteristic components closely related to the centenarians were identified, including acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid. Their concentrations were significantly higher in the centenarians group (p < 0.05). Additionally, the dietary fiber intake was positively associated with butyric acid contents in feces (r = 0.896, p < 0.01), and negatively associated with phenol in urine (r = −0.326, p < 0.01). The results suggest that the specific metabolic pattern of centenarians may have an important and positive influence on the formation of the longevity phenomenon. Elevated dietary fiber intake should be a path toward health and longevity.

No MeSH data available.


V plot of the partial least squares-discriminant analysis of overall indexes including the metabolites and elements in the three groups. Each triangle denotes an individual component. The triangles far away from the origin represent the components responsible for the differences among the three groups. The acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid are the farthest away from the origin in the V plot, which further indicates that they are the differential components obtained from the PLS-DA model. Acet, acetic acid; Prop, propionic acid; Buty, butyric acid; Isobu, isobutyric acid; Vale, valeric acid; Isova, isovaleric acid; T-SCFA, total SCFA; TBA, total bile acids; Phen, phenol; p-Cre, p-cresol; UA, uric acid; CREA, creatinine; Fec Amm, fecal ammonia; Uri Amm, urinary ammonia.
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nutrients-08-00564-f005: V plot of the partial least squares-discriminant analysis of overall indexes including the metabolites and elements in the three groups. Each triangle denotes an individual component. The triangles far away from the origin represent the components responsible for the differences among the three groups. The acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid are the farthest away from the origin in the V plot, which further indicates that they are the differential components obtained from the PLS-DA model. Acet, acetic acid; Prop, propionic acid; Buty, butyric acid; Isobu, isobutyric acid; Vale, valeric acid; Isova, isovaleric acid; T-SCFA, total SCFA; TBA, total bile acids; Phen, phenol; p-Cre, p-cresol; UA, uric acid; CREA, creatinine; Fec Amm, fecal ammonia; Uri Amm, urinary ammonia.

Mentions: Besides, the differential components were further verified by the V plot of the PLS-DA model, as shown in Figure 5. In the V plot, each triangle denoted an individual component. The triangles far away from the origin represented the components responsible for the differences among the three groups. The abovementioned differential components, including acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid, were the farthest away from the origin in the V plot, which further indicated that they were the differential components obtained from the PLS-DA model.


Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians
V plot of the partial least squares-discriminant analysis of overall indexes including the metabolites and elements in the three groups. Each triangle denotes an individual component. The triangles far away from the origin represent the components responsible for the differences among the three groups. The acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid are the farthest away from the origin in the V plot, which further indicates that they are the differential components obtained from the PLS-DA model. Acet, acetic acid; Prop, propionic acid; Buty, butyric acid; Isobu, isobutyric acid; Vale, valeric acid; Isova, isovaleric acid; T-SCFA, total SCFA; TBA, total bile acids; Phen, phenol; p-Cre, p-cresol; UA, uric acid; CREA, creatinine; Fec Amm, fecal ammonia; Uri Amm, urinary ammonia.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037549&req=5

nutrients-08-00564-f005: V plot of the partial least squares-discriminant analysis of overall indexes including the metabolites and elements in the three groups. Each triangle denotes an individual component. The triangles far away from the origin represent the components responsible for the differences among the three groups. The acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid are the farthest away from the origin in the V plot, which further indicates that they are the differential components obtained from the PLS-DA model. Acet, acetic acid; Prop, propionic acid; Buty, butyric acid; Isobu, isobutyric acid; Vale, valeric acid; Isova, isovaleric acid; T-SCFA, total SCFA; TBA, total bile acids; Phen, phenol; p-Cre, p-cresol; UA, uric acid; CREA, creatinine; Fec Amm, fecal ammonia; Uri Amm, urinary ammonia.
Mentions: Besides, the differential components were further verified by the V plot of the PLS-DA model, as shown in Figure 5. In the V plot, each triangle denoted an individual component. The triangles far away from the origin represented the components responsible for the differences among the three groups. The abovementioned differential components, including acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid, were the farthest away from the origin in the V plot, which further indicated that they were the differential components obtained from the PLS-DA model.

View Article: PubMed Central - PubMed

ABSTRACT

The relationships between diet and metabolites as well as element profiles in healthy centenarians are important but remain inconclusive. Therefore, to test the interesting hypothesis that there would be distinctive features of metabolites and element profiles in healthy centenarians, and that these would be associated with nutrient intake; the short chain fatty acids (SCFAs), total bile acids and ammonia in feces, phenol, p-cresol, uric acid, urea, creatinine and ammonia in urine, and element profiles in fingernails were determined in 90 healthy elderly people, including centenarians from Bama county (China)—a famous longevous region—and elderly people aged 80–99 from the longevous region and a non-longevous region. The partial least squares-discriminant analysis was used for pattern recognition. As a result, the centenarians showed a distinct metabolic pattern. Seven characteristic components closely related to the centenarians were identified, including acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid. Their concentrations were significantly higher in the centenarians group (p < 0.05). Additionally, the dietary fiber intake was positively associated with butyric acid contents in feces (r = 0.896, p < 0.01), and negatively associated with phenol in urine (r = −0.326, p < 0.01). The results suggest that the specific metabolic pattern of centenarians may have an important and positive influence on the formation of the longevity phenomenon. Elevated dietary fiber intake should be a path toward health and longevity.

No MeSH data available.