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Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians

View Article: PubMed Central - PubMed

ABSTRACT

The relationships between diet and metabolites as well as element profiles in healthy centenarians are important but remain inconclusive. Therefore, to test the interesting hypothesis that there would be distinctive features of metabolites and element profiles in healthy centenarians, and that these would be associated with nutrient intake; the short chain fatty acids (SCFAs), total bile acids and ammonia in feces, phenol, p-cresol, uric acid, urea, creatinine and ammonia in urine, and element profiles in fingernails were determined in 90 healthy elderly people, including centenarians from Bama county (China)—a famous longevous region—and elderly people aged 80–99 from the longevous region and a non-longevous region. The partial least squares-discriminant analysis was used for pattern recognition. As a result, the centenarians showed a distinct metabolic pattern. Seven characteristic components closely related to the centenarians were identified, including acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid. Their concentrations were significantly higher in the centenarians group (p < 0.05). Additionally, the dietary fiber intake was positively associated with butyric acid contents in feces (r = 0.896, p < 0.01), and negatively associated with phenol in urine (r = −0.326, p < 0.01). The results suggest that the specific metabolic pattern of centenarians may have an important and positive influence on the formation of the longevity phenomenon. Elevated dietary fiber intake should be a path toward health and longevity.

No MeSH data available.


Flow diagram of participants during the study.
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nutrients-08-00564-f001: Flow diagram of participants during the study.

Mentions: Forty-nine centenarians were enrolled in the LRC group, and 59 elderly people from the LR and 61 elderly people from the NLR were enrolled in the LRE group and NLRE group, respectively. Among these volunteers, 37 centenarians in the LRC group, 43 elderly people in the LRE group and 40 elderly people in the NLRE group met the screening criteria and started the study. Of these, 30 centenarians in the LRC group (11 male/19 female, age: 103 ± 3 years), 30 elderly people in the LRE group (12 male/18 female, age: 87 ± 5 years), and 30 elderly people in the NLRE group (13 male/17 female, age: 88 ± 4 years) completed the study protocol (Figure 1). The characteristics of the participants are shown in Table 1. There is no significant difference in age between the LRE group and NLRE group (p > 0.05), as well as in sex ratio among the three groups (p > 0.05).


Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians
Flow diagram of participants during the study.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037549&req=5

nutrients-08-00564-f001: Flow diagram of participants during the study.
Mentions: Forty-nine centenarians were enrolled in the LRC group, and 59 elderly people from the LR and 61 elderly people from the NLR were enrolled in the LRE group and NLRE group, respectively. Among these volunteers, 37 centenarians in the LRC group, 43 elderly people in the LRE group and 40 elderly people in the NLRE group met the screening criteria and started the study. Of these, 30 centenarians in the LRC group (11 male/19 female, age: 103 ± 3 years), 30 elderly people in the LRE group (12 male/18 female, age: 87 ± 5 years), and 30 elderly people in the NLRE group (13 male/17 female, age: 88 ± 4 years) completed the study protocol (Figure 1). The characteristics of the participants are shown in Table 1. There is no significant difference in age between the LRE group and NLRE group (p > 0.05), as well as in sex ratio among the three groups (p > 0.05).

View Article: PubMed Central - PubMed

ABSTRACT

The relationships between diet and metabolites as well as element profiles in healthy centenarians are important but remain inconclusive. Therefore, to test the interesting hypothesis that there would be distinctive features of metabolites and element profiles in healthy centenarians, and that these would be associated with nutrient intake; the short chain fatty acids (SCFAs), total bile acids and ammonia in feces, phenol, p-cresol, uric acid, urea, creatinine and ammonia in urine, and element profiles in fingernails were determined in 90 healthy elderly people, including centenarians from Bama county (China)—a famous longevous region—and elderly people aged 80–99 from the longevous region and a non-longevous region. The partial least squares-discriminant analysis was used for pattern recognition. As a result, the centenarians showed a distinct metabolic pattern. Seven characteristic components closely related to the centenarians were identified, including acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid. Their concentrations were significantly higher in the centenarians group (p < 0.05). Additionally, the dietary fiber intake was positively associated with butyric acid contents in feces (r = 0.896, p < 0.01), and negatively associated with phenol in urine (r = −0.326, p < 0.01). The results suggest that the specific metabolic pattern of centenarians may have an important and positive influence on the formation of the longevity phenomenon. Elevated dietary fiber intake should be a path toward health and longevity.

No MeSH data available.