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The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II

View Article: PubMed Central - PubMed

ABSTRACT

Cancer is one of the leading causes of deaths worldwide. Compounds derived from traditional Chinese medicines have been an important source of anticancer drugs and adjuvant agents to potentiate the efficacy of chemotherapeutic drugs and improve the side effects of chemotherapy. HerbaEpimedii is one of most popular herbs used in China traditionally for the treatment of multiple diseases, including osteoporosis, sexual dysfunction, hypertension and common inflammatory diseases. Studies show HerbaEpimedii also possesses anticancer activity. Flavonol glycosides icariin and icariside II are the main bioactive components of HerbaEpimedii. They have been found to possess anticancer activities against various human cancer cell lines in vitro and mouse tumor models in vivo via their effects on multiple biological pathways, including cell cycle regulation, apoptosis, angiogenesis, and metastasis, and a variety of signaling pathways including JAK2-STAT3, MAPK-ERK, and PI3k-Akt-mTOR. The review is aimed to provide an overview of the current research results supporting their therapeutic effects and to highlight the molecular targets and action mechanisms.

No MeSH data available.


Related in: MedlinePlus

The cell cycle arrest induced by icariin and icariside II. Icariin and icariside II stimulate cell cycle arrest via suppression of the CDKs and cyclins at different stages, (← activation; ⊥ inhibition).
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nutrients-08-00563-f003: The cell cycle arrest induced by icariin and icariside II. Icariin and icariside II stimulate cell cycle arrest via suppression of the CDKs and cyclins at different stages, (← activation; ⊥ inhibition).

Mentions: As shown in Figure 3, there are five active CDKs during the cell cycle, CDK2, CDK4 and CDK6 for G1, CDK2 for S, and CDK1 for both G2 and M. The complexes of cyclin D with CDK4 or CDK6 promote the progression through G1, cyclin E/CDK2 activates G1 into S, cyclin A/CDK2 promotes S progression, cyclin A/CDK1 activates G2 into M, while cyclin B/CDK1 stimulates the mitotic phase [75]. Disorders in the regulatory control of cell cycle could lead to the formation of tumors, characterized by the unlimited cell proliferation and abnormal apoptosis. Overexpression of cyclin D1 has been recognized as one of the distinct features in many types of human tumors [76]. Suppression of deregulated cell cycle progression in cancer cells by inhibiting the activities of CDKs or the cyclins have been considered as an effective strategy to inhibit the proliferation of the tumors [77].


The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II
The cell cycle arrest induced by icariin and icariside II. Icariin and icariside II stimulate cell cycle arrest via suppression of the CDKs and cyclins at different stages, (← activation; ⊥ inhibition).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037548&req=5

nutrients-08-00563-f003: The cell cycle arrest induced by icariin and icariside II. Icariin and icariside II stimulate cell cycle arrest via suppression of the CDKs and cyclins at different stages, (← activation; ⊥ inhibition).
Mentions: As shown in Figure 3, there are five active CDKs during the cell cycle, CDK2, CDK4 and CDK6 for G1, CDK2 for S, and CDK1 for both G2 and M. The complexes of cyclin D with CDK4 or CDK6 promote the progression through G1, cyclin E/CDK2 activates G1 into S, cyclin A/CDK2 promotes S progression, cyclin A/CDK1 activates G2 into M, while cyclin B/CDK1 stimulates the mitotic phase [75]. Disorders in the regulatory control of cell cycle could lead to the formation of tumors, characterized by the unlimited cell proliferation and abnormal apoptosis. Overexpression of cyclin D1 has been recognized as one of the distinct features in many types of human tumors [76]. Suppression of deregulated cell cycle progression in cancer cells by inhibiting the activities of CDKs or the cyclins have been considered as an effective strategy to inhibit the proliferation of the tumors [77].

View Article: PubMed Central - PubMed

ABSTRACT

Cancer is one of the leading causes of deaths worldwide. Compounds derived from traditional Chinese medicines have been an important source of anticancer drugs and adjuvant agents to potentiate the efficacy of chemotherapeutic drugs and improve the side effects of chemotherapy. HerbaEpimedii is one of most popular herbs used in China traditionally for the treatment of multiple diseases, including osteoporosis, sexual dysfunction, hypertension and common inflammatory diseases. Studies show HerbaEpimedii also possesses anticancer activity. Flavonol glycosides icariin and icariside II are the main bioactive components of HerbaEpimedii. They have been found to possess anticancer activities against various human cancer cell lines in vitro and mouse tumor models in vivo via their effects on multiple biological pathways, including cell cycle regulation, apoptosis, angiogenesis, and metastasis, and a variety of signaling pathways including JAK2-STAT3, MAPK-ERK, and PI3k-Akt-mTOR. The review is aimed to provide an overview of the current research results supporting their therapeutic effects and to highlight the molecular targets and action mechanisms.

No MeSH data available.


Related in: MedlinePlus