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The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II

View Article: PubMed Central - PubMed

ABSTRACT

Cancer is one of the leading causes of deaths worldwide. Compounds derived from traditional Chinese medicines have been an important source of anticancer drugs and adjuvant agents to potentiate the efficacy of chemotherapeutic drugs and improve the side effects of chemotherapy. HerbaEpimedii is one of most popular herbs used in China traditionally for the treatment of multiple diseases, including osteoporosis, sexual dysfunction, hypertension and common inflammatory diseases. Studies show HerbaEpimedii also possesses anticancer activity. Flavonol glycosides icariin and icariside II are the main bioactive components of HerbaEpimedii. They have been found to possess anticancer activities against various human cancer cell lines in vitro and mouse tumor models in vivo via their effects on multiple biological pathways, including cell cycle regulation, apoptosis, angiogenesis, and metastasis, and a variety of signaling pathways including JAK2-STAT3, MAPK-ERK, and PI3k-Akt-mTOR. The review is aimed to provide an overview of the current research results supporting their therapeutic effects and to highlight the molecular targets and action mechanisms.

No MeSH data available.


Related in: MedlinePlus

Overview of the anti-cancer effects of icariin and icariside II. Icariin and icariside II stimulate the cell cycle arrest via upregulation of p38, p53, and p21. Icariin and icariside II are involved in the induction of apoptosis and inhibit tumor angiogenesis and metastasis via suppression of multiple signaling pathways. They also have anti-inflammatory effects via downregulation of several factors, such as IFN-γ, iNOs, and COX-2, (← activation; ⊥ inhibition; ↑, up-regulation; ↓, down-regulation).
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nutrients-08-00563-f002: Overview of the anti-cancer effects of icariin and icariside II. Icariin and icariside II stimulate the cell cycle arrest via upregulation of p38, p53, and p21. Icariin and icariside II are involved in the induction of apoptosis and inhibit tumor angiogenesis and metastasis via suppression of multiple signaling pathways. They also have anti-inflammatory effects via downregulation of several factors, such as IFN-γ, iNOs, and COX-2, (← activation; ⊥ inhibition; ↑, up-regulation; ↓, down-regulation).

Mentions: Multiple studies have been performed to investigate the mechanisms by which icariin and icariside II exert their anti-tumor effects. The mechanisms are comprehensive and diverse, involving the regulation of a variety of targets, which play a particularly important role in the process of tumor proliferation, invasion, angiogenesis, metastasis and apoptosis. Besides the effects of icariin and icariside II on numerous signaling proteins and transcription factors, they also regulate the stages of the tumor cells by inhibiting proliferation and inducing apoptosis. In addition, they could play their anti-tumor effect through improving the tumor inflammatory microenvironment (Figure 2). Icariin and icariside II might be considered as potential chemotherapeutic agents for the treatment of various human cancers due to their multiple targets on the cell growth processes.


The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II
Overview of the anti-cancer effects of icariin and icariside II. Icariin and icariside II stimulate the cell cycle arrest via upregulation of p38, p53, and p21. Icariin and icariside II are involved in the induction of apoptosis and inhibit tumor angiogenesis and metastasis via suppression of multiple signaling pathways. They also have anti-inflammatory effects via downregulation of several factors, such as IFN-γ, iNOs, and COX-2, (← activation; ⊥ inhibition; ↑, up-regulation; ↓, down-regulation).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037548&req=5

nutrients-08-00563-f002: Overview of the anti-cancer effects of icariin and icariside II. Icariin and icariside II stimulate the cell cycle arrest via upregulation of p38, p53, and p21. Icariin and icariside II are involved in the induction of apoptosis and inhibit tumor angiogenesis and metastasis via suppression of multiple signaling pathways. They also have anti-inflammatory effects via downregulation of several factors, such as IFN-γ, iNOs, and COX-2, (← activation; ⊥ inhibition; ↑, up-regulation; ↓, down-regulation).
Mentions: Multiple studies have been performed to investigate the mechanisms by which icariin and icariside II exert their anti-tumor effects. The mechanisms are comprehensive and diverse, involving the regulation of a variety of targets, which play a particularly important role in the process of tumor proliferation, invasion, angiogenesis, metastasis and apoptosis. Besides the effects of icariin and icariside II on numerous signaling proteins and transcription factors, they also regulate the stages of the tumor cells by inhibiting proliferation and inducing apoptosis. In addition, they could play their anti-tumor effect through improving the tumor inflammatory microenvironment (Figure 2). Icariin and icariside II might be considered as potential chemotherapeutic agents for the treatment of various human cancers due to their multiple targets on the cell growth processes.

View Article: PubMed Central - PubMed

ABSTRACT

Cancer is one of the leading causes of deaths worldwide. Compounds derived from traditional Chinese medicines have been an important source of anticancer drugs and adjuvant agents to potentiate the efficacy of chemotherapeutic drugs and improve the side effects of chemotherapy. HerbaEpimedii is one of most popular herbs used in China traditionally for the treatment of multiple diseases, including osteoporosis, sexual dysfunction, hypertension and common inflammatory diseases. Studies show HerbaEpimedii also possesses anticancer activity. Flavonol glycosides icariin and icariside II are the main bioactive components of HerbaEpimedii. They have been found to possess anticancer activities against various human cancer cell lines in vitro and mouse tumor models in vivo via their effects on multiple biological pathways, including cell cycle regulation, apoptosis, angiogenesis, and metastasis, and a variety of signaling pathways including JAK2-STAT3, MAPK-ERK, and PI3k-Akt-mTOR. The review is aimed to provide an overview of the current research results supporting their therapeutic effects and to highlight the molecular targets and action mechanisms.

No MeSH data available.


Related in: MedlinePlus