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The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II

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ABSTRACT

Cancer is one of the leading causes of deaths worldwide. Compounds derived from traditional Chinese medicines have been an important source of anticancer drugs and adjuvant agents to potentiate the efficacy of chemotherapeutic drugs and improve the side effects of chemotherapy. HerbaEpimedii is one of most popular herbs used in China traditionally for the treatment of multiple diseases, including osteoporosis, sexual dysfunction, hypertension and common inflammatory diseases. Studies show HerbaEpimedii also possesses anticancer activity. Flavonol glycosides icariin and icariside II are the main bioactive components of HerbaEpimedii. They have been found to possess anticancer activities against various human cancer cell lines in vitro and mouse tumor models in vivo via their effects on multiple biological pathways, including cell cycle regulation, apoptosis, angiogenesis, and metastasis, and a variety of signaling pathways including JAK2-STAT3, MAPK-ERK, and PI3k-Akt-mTOR. The review is aimed to provide an overview of the current research results supporting their therapeutic effects and to highlight the molecular targets and action mechanisms.

No MeSH data available.


Natural sources and chemical structures of icariin and icariside II [18,19]. Herba Epimedii is made up of the dried leaves of E.brevicornu, E.sagittatum, E.pubescens or E.koreanum.
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nutrients-08-00563-f001: Natural sources and chemical structures of icariin and icariside II [18,19]. Herba Epimedii is made up of the dried leaves of E.brevicornu, E.sagittatum, E.pubescens or E.koreanum.

Mentions: HerbaEpimedii (Common name: Yin-yang-huo in China, Figure 1) is the dried leaf of Epimediumbrevicornu Maxim., Epimediumsagittatum (Sieb. EtZucc.) Maxim., Epimediumpubescens Maxim. or Epimediumkoreanum Nakaias as recorded in the Chinese Pharmacopoeia (Figure 1) [10]. There are more than 40 kinds of Epimedium plants all over the world, mainly distributed in the southwest and central regions of China, although some are found in the temperate and subtropical regions of Asia, Middle East as well as Europe [11]. HerbaEpimedii has been recorded in the Chinese medical classics ShenNong Ben Cao Jing 400 years ago and has been used in various traditional Chinese formulations. The herb is believed to “nourishing the kidney and reinforcing the Yang” and is proven to have remarkably therapeutic activities. In China and Japan, HerbaEpimedii alone, or in the formulations, have been widely used for treatment of osteoporosis [12,13], sexual dysfunction [14], hypertension [15] and common inflammatory diseases, such as chronic obstructive pulmonary disease [16]. In addition, HerbaEpimedii has been shown to exert anticancer effect on cancer cell lines in vitro and also in vivo in mouse tumor model [17].


The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II
Natural sources and chemical structures of icariin and icariside II [18,19]. Herba Epimedii is made up of the dried leaves of E.brevicornu, E.sagittatum, E.pubescens or E.koreanum.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037548&req=5

nutrients-08-00563-f001: Natural sources and chemical structures of icariin and icariside II [18,19]. Herba Epimedii is made up of the dried leaves of E.brevicornu, E.sagittatum, E.pubescens or E.koreanum.
Mentions: HerbaEpimedii (Common name: Yin-yang-huo in China, Figure 1) is the dried leaf of Epimediumbrevicornu Maxim., Epimediumsagittatum (Sieb. EtZucc.) Maxim., Epimediumpubescens Maxim. or Epimediumkoreanum Nakaias as recorded in the Chinese Pharmacopoeia (Figure 1) [10]. There are more than 40 kinds of Epimedium plants all over the world, mainly distributed in the southwest and central regions of China, although some are found in the temperate and subtropical regions of Asia, Middle East as well as Europe [11]. HerbaEpimedii has been recorded in the Chinese medical classics ShenNong Ben Cao Jing 400 years ago and has been used in various traditional Chinese formulations. The herb is believed to “nourishing the kidney and reinforcing the Yang” and is proven to have remarkably therapeutic activities. In China and Japan, HerbaEpimedii alone, or in the formulations, have been widely used for treatment of osteoporosis [12,13], sexual dysfunction [14], hypertension [15] and common inflammatory diseases, such as chronic obstructive pulmonary disease [16]. In addition, HerbaEpimedii has been shown to exert anticancer effect on cancer cell lines in vitro and also in vivo in mouse tumor model [17].

View Article: PubMed Central - PubMed

ABSTRACT

Cancer is one of the leading causes of deaths worldwide. Compounds derived from traditional Chinese medicines have been an important source of anticancer drugs and adjuvant agents to potentiate the efficacy of chemotherapeutic drugs and improve the side effects of chemotherapy. HerbaEpimedii is one of most popular herbs used in China traditionally for the treatment of multiple diseases, including osteoporosis, sexual dysfunction, hypertension and common inflammatory diseases. Studies show HerbaEpimedii also possesses anticancer activity. Flavonol glycosides icariin and icariside II are the main bioactive components of HerbaEpimedii. They have been found to possess anticancer activities against various human cancer cell lines in vitro and mouse tumor models in vivo via their effects on multiple biological pathways, including cell cycle regulation, apoptosis, angiogenesis, and metastasis, and a variety of signaling pathways including JAK2-STAT3, MAPK-ERK, and PI3k-Akt-mTOR. The review is aimed to provide an overview of the current research results supporting their therapeutic effects and to highlight the molecular targets and action mechanisms.

No MeSH data available.