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Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update

View Article: PubMed Central - PubMed

ABSTRACT

Quercetin, a medicinally important member of the flavonoid family, is one of the most prominent dietary antioxidants. It is present in a variety of foods—including fruits, vegetables, tea, wine, as well as other dietary supplements—and is responsible for various health benefits. Numerous pharmacological effects of quercetin include protection against diseases, such as osteoporosis, certain forms of malignant tumors, and pulmonary and cardiovascular disorders. Quercetin has the special ability of scavenging highly reactive species, such as hydrogen peroxide, superoxide anion, and hydroxyl radicals. These oxygen radicals are called reactive oxygen species, which can cause oxidative damage to cellular components, such as proteins, lipids, and deoxyribonucleic acid. Various oxygen radicals play important roles in pathophysiological and degenerative processes, such as aging. Subsequently, several studies have been performed to evaluate possible advantageous health effects of quercetin and to collect scientific evidence for these beneficial health claims. These studies also gather data in order to evaluate the exact mechanism(s) of action and toxicological effects of quercetin. The purpose of this review is to present and critically analyze molecular pathways underlying the anticancer effects of quercetin. Current limitations and future directions of research on this bioactive dietary polyphenol are also critically discussed.

No MeSH data available.


Flow diagram of included studies. The number of citations and resource materials that have been screened, excluded and/or included in this review is indicated in parenthesis.
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nutrients-08-00529-f001: Flow diagram of included studies. The number of citations and resource materials that have been screened, excluded and/or included in this review is indicated in parenthesis.

Mentions: The scientific information gathered in this review was collected by widespread search of several electronic databases, including PubMed, Scopus, Medline, Web of Science, EBASE, and Google Scholar. The criteria for the exclusion of articles was the language of reports being other than English, reports with unavailable abstracts, studies related to quercetin effects apart from its anticancer profile, and studies which showed the linkage between cancer and cancer risk factors, such as tobacco smoking and alcohol consumption. Various appropriate articles not indexed by PubMed were also considered, and 27 such reports which fulfilled the criteria for inclusion were further recovered from Google Scholar. Therefore, the total number of included articles in this review is 127 (Figure 1).


Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update
Flow diagram of included studies. The number of citations and resource materials that have been screened, excluded and/or included in this review is indicated in parenthesis.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037516&req=5

nutrients-08-00529-f001: Flow diagram of included studies. The number of citations and resource materials that have been screened, excluded and/or included in this review is indicated in parenthesis.
Mentions: The scientific information gathered in this review was collected by widespread search of several electronic databases, including PubMed, Scopus, Medline, Web of Science, EBASE, and Google Scholar. The criteria for the exclusion of articles was the language of reports being other than English, reports with unavailable abstracts, studies related to quercetin effects apart from its anticancer profile, and studies which showed the linkage between cancer and cancer risk factors, such as tobacco smoking and alcohol consumption. Various appropriate articles not indexed by PubMed were also considered, and 27 such reports which fulfilled the criteria for inclusion were further recovered from Google Scholar. Therefore, the total number of included articles in this review is 127 (Figure 1).

View Article: PubMed Central - PubMed

ABSTRACT

Quercetin, a medicinally important member of the flavonoid family, is one of the most prominent dietary antioxidants. It is present in a variety of foods—including fruits, vegetables, tea, wine, as well as other dietary supplements—and is responsible for various health benefits. Numerous pharmacological effects of quercetin include protection against diseases, such as osteoporosis, certain forms of malignant tumors, and pulmonary and cardiovascular disorders. Quercetin has the special ability of scavenging highly reactive species, such as hydrogen peroxide, superoxide anion, and hydroxyl radicals. These oxygen radicals are called reactive oxygen species, which can cause oxidative damage to cellular components, such as proteins, lipids, and deoxyribonucleic acid. Various oxygen radicals play important roles in pathophysiological and degenerative processes, such as aging. Subsequently, several studies have been performed to evaluate possible advantageous health effects of quercetin and to collect scientific evidence for these beneficial health claims. These studies also gather data in order to evaluate the exact mechanism(s) of action and toxicological effects of quercetin. The purpose of this review is to present and critically analyze molecular pathways underlying the anticancer effects of quercetin. Current limitations and future directions of research on this bioactive dietary polyphenol are also critically discussed.

No MeSH data available.