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Associations between Dietary Nutrient Intakes and Hepatic Lipid Contents in NAFLD Patients Quantified by 1 H-MRS and Dual-Echo MRI

View Article: PubMed Central - PubMed

ABSTRACT

Dietary habits are crucial in the progression of hepatic lipid accumulation and nonalcoholic fatty liver disease (NAFLD). However, there are limited studies using 1H-magnetic resonance spectroscopy (1H-MRS) and dual-echo in-phase and out-phase magnetic resonance spectroscopy imaging (dual-echo MRI) to assess the effects of dietary nutrient intakes on hepatic lipid contents. In the present study, we recruited 36 female adults (NAFLD:control = 19:17) to receive questionnaires and medical examinations, including dietary intakes, anthropometric and biochemical measurements, and 1H-MRS and dual-echo MRI examinations. NAFLD patients were found to consume diets higher in energy, protein, fat, saturated fatty acid (SFA), and polyunsaturated fatty acid (PUFA). Total energy intake was positively associated with hepatic fat fraction (HFF) and intrahepatic lipid (IHL) after adjustment for age and body-mass index (BMI) (HFF: β = 0.24, p = 0.02; IHL: β = 0.38, p = 0.02). Total fat intake was positively associated with HFF and IHL after adjustment for age, BMI and total energy intake (HFF: β = 0.36, p = 0.03; IHL: β = 0.42, p = 0.01). SFA intake was positively associated with HFF and IHL after adjustments (HFF: β = 0.45, p = 0.003; IHL: β = 1.16, p = 0.03). In conclusion, hepatic fat content was associated with high energy, high fat and high SFA intakes, quantified by 1H-MRS and dual-echo MRI in our population. Our findings are useful to provide dietary targets to prevent the hepatic lipid accumulation and NAFLD.

No MeSH data available.


Related in: MedlinePlus

Typical spectra obtained from a NAFLD patient ((a), IHL = 36.1%) and a healthy individual ((b), IHL = 0.4%) showed the water signals and the lipid signals for calculating the IHL values.
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nutrients-08-00527-f002: Typical spectra obtained from a NAFLD patient ((a), IHL = 36.1%) and a healthy individual ((b), IHL = 0.4%) showed the water signals and the lipid signals for calculating the IHL values.

Mentions: The degree of hepatic lipid contents assessed by IHL and HFF is presented in Table 2. For the examination by dual-echo MRI, the fat and water signals within a voxel were, respectively, additive and subtractive in the in-phase image and the opposed-phase image (Figure 1). In the images of NAFLD patients, there was a decrease of the signal intensity from the in-phase to an opposed-phase image. NAFLD patients showed significantly higher HFF than controls. Figure 2 showed typical examples of 1H spectra for a NAFLD patient (A) and a control subject (B). NAFLD group had higher IHL, which contrasted sharply with controls.


Associations between Dietary Nutrient Intakes and Hepatic Lipid Contents in NAFLD Patients Quantified by 1 H-MRS and Dual-Echo MRI
Typical spectra obtained from a NAFLD patient ((a), IHL = 36.1%) and a healthy individual ((b), IHL = 0.4%) showed the water signals and the lipid signals for calculating the IHL values.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037514&req=5

nutrients-08-00527-f002: Typical spectra obtained from a NAFLD patient ((a), IHL = 36.1%) and a healthy individual ((b), IHL = 0.4%) showed the water signals and the lipid signals for calculating the IHL values.
Mentions: The degree of hepatic lipid contents assessed by IHL and HFF is presented in Table 2. For the examination by dual-echo MRI, the fat and water signals within a voxel were, respectively, additive and subtractive in the in-phase image and the opposed-phase image (Figure 1). In the images of NAFLD patients, there was a decrease of the signal intensity from the in-phase to an opposed-phase image. NAFLD patients showed significantly higher HFF than controls. Figure 2 showed typical examples of 1H spectra for a NAFLD patient (A) and a control subject (B). NAFLD group had higher IHL, which contrasted sharply with controls.

View Article: PubMed Central - PubMed

ABSTRACT

Dietary habits are crucial in the progression of hepatic lipid accumulation and nonalcoholic fatty liver disease (NAFLD). However, there are limited studies using 1H-magnetic resonance spectroscopy (1H-MRS) and dual-echo in-phase and out-phase magnetic resonance spectroscopy imaging (dual-echo MRI) to assess the effects of dietary nutrient intakes on hepatic lipid contents. In the present study, we recruited 36 female adults (NAFLD:control = 19:17) to receive questionnaires and medical examinations, including dietary intakes, anthropometric and biochemical measurements, and 1H-MRS and dual-echo MRI examinations. NAFLD patients were found to consume diets higher in energy, protein, fat, saturated fatty acid (SFA), and polyunsaturated fatty acid (PUFA). Total energy intake was positively associated with hepatic fat fraction (HFF) and intrahepatic lipid (IHL) after adjustment for age and body-mass index (BMI) (HFF: β = 0.24, p = 0.02; IHL: β = 0.38, p = 0.02). Total fat intake was positively associated with HFF and IHL after adjustment for age, BMI and total energy intake (HFF: β = 0.36, p = 0.03; IHL: β = 0.42, p = 0.01). SFA intake was positively associated with HFF and IHL after adjustments (HFF: β = 0.45, p = 0.003; IHL: β = 1.16, p = 0.03). In conclusion, hepatic fat content was associated with high energy, high fat and high SFA intakes, quantified by 1H-MRS and dual-echo MRI in our population. Our findings are useful to provide dietary targets to prevent the hepatic lipid accumulation and NAFLD.

No MeSH data available.


Related in: MedlinePlus