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Effects of post-traumatic growth on the dorsolateral prefrontal cortex after a disaster

View Article: PubMed Central - PubMed

ABSTRACT

The relating to others factor of post-traumatic growth (PTG), which involves mutual help and a strong sense of connection with humanity, is important for young people who are coping with stress. The prefrontal cortex (PFC), especially the dorsolateral PFC (DLPFC), may play an important role in post-traumatic stress disorder (PTSD) with regard to coping and resilience. We hypothesized that the neural correlates of PTG may be responsible for resilience to the correlates of PTSD. Our study tested this hypothesis by examining whether measures of PTG, particularly the measures of relating to others after a disaster, were associated with increased regional grey matter volume (rGMV) in the PFC by assessing individuals who had experienced the East Japan Great Earthquake. We calculated the delta-rGMV by subtracting the rGMV obtained 3 months before the disaster from the rGMV obtained after this disaster using voxel-based morphometry. The magnetic resonance imaging data obtained from 26 subjects (M/F: 21/5; age: 21.2 ± 1.6 yrs.) showed that the total scores on a PTG inventory and the subscore for relating to others at the post-assessment were positively and significantly associated with the delta-rGMV in the right DLPFC. The DLPFC seems to be the main neural correlate of PTG.

No MeSH data available.


(a) Regions that were correlated with the delta-rGMV values from the significant peak voxel. After controlling for sex, age, and total intracranial volume (TIV), the subscore for relating to others was positively associated with the delta- rGMV in the right dorsolateral prefrontal cortex (DLPFC) (x = 54, y = 38, z = 25; Threshold-free cluster enhancement [TFCE] = 3405.80, P = 0.027, k = 917), with a family-wise error (FWE) correction. A scatterplot of the relationship between the scores for relating to others and the delta-rGMV value from the significant peak voxel is shown. (b) Regions that were correlated with the delta-rGMV values from the significant peak voxel and total score on the PTGI. After controlling for sex, age, and TIV, the total score on the post-traumatic growth inventory (PTGI) was positively associated with the delta-rGMV in the right DLPFC (x = 54, y = 42, z = 22; Threshold-free cluster enhancement [TFCE] = 1376.47, P = 0.031, k = 504), with a family-wise error (FWE) correction through small volume correction (SVC) using a mask with regions that are functionally and structurally related to the DLPFC. A scatterplot of the relationship between the total scores on the PTGI and the delta-rGMV value from the significant peak voxel is shown.
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f2: (a) Regions that were correlated with the delta-rGMV values from the significant peak voxel. After controlling for sex, age, and total intracranial volume (TIV), the subscore for relating to others was positively associated with the delta- rGMV in the right dorsolateral prefrontal cortex (DLPFC) (x = 54, y = 38, z = 25; Threshold-free cluster enhancement [TFCE] = 3405.80, P = 0.027, k = 917), with a family-wise error (FWE) correction. A scatterplot of the relationship between the scores for relating to others and the delta-rGMV value from the significant peak voxel is shown. (b) Regions that were correlated with the delta-rGMV values from the significant peak voxel and total score on the PTGI. After controlling for sex, age, and TIV, the total score on the post-traumatic growth inventory (PTGI) was positively associated with the delta-rGMV in the right DLPFC (x = 54, y = 42, z = 22; Threshold-free cluster enhancement [TFCE] = 1376.47, P = 0.031, k = 504), with a family-wise error (FWE) correction through small volume correction (SVC) using a mask with regions that are functionally and structurally related to the DLPFC. A scatterplot of the relationship between the total scores on the PTGI and the delta-rGMV value from the significant peak voxel is shown.

Mentions: After controlling for sex; age; total intracranial volumes (TIV; total GMV+ total white matter volume [WMV]+ total cerebrospinal fluid volume); total scores on the RAPM, CAPS, and CES-D; score on the T-A subscale of the STAI at post; and the interval between the pre- and post-magnetic resonance imaging (MRI) data acquisitions, the whole-brain analysis revealed delta-rGMV in the right DLPFC was significantly correlated to the subscore for relating to others (x = 54, y = 38, z = 25; threshold-free cluster enhancement [TFCE] = 3,405.80, P = 0.027, k = 917, with family-wise error [FWE] correction) (Fig. 2a).


Effects of post-traumatic growth on the dorsolateral prefrontal cortex after a disaster
(a) Regions that were correlated with the delta-rGMV values from the significant peak voxel. After controlling for sex, age, and total intracranial volume (TIV), the subscore for relating to others was positively associated with the delta- rGMV in the right dorsolateral prefrontal cortex (DLPFC) (x = 54, y = 38, z = 25; Threshold-free cluster enhancement [TFCE] = 3405.80, P = 0.027, k = 917), with a family-wise error (FWE) correction. A scatterplot of the relationship between the scores for relating to others and the delta-rGMV value from the significant peak voxel is shown. (b) Regions that were correlated with the delta-rGMV values from the significant peak voxel and total score on the PTGI. After controlling for sex, age, and TIV, the total score on the post-traumatic growth inventory (PTGI) was positively associated with the delta-rGMV in the right DLPFC (x = 54, y = 42, z = 22; Threshold-free cluster enhancement [TFCE] = 1376.47, P = 0.031, k = 504), with a family-wise error (FWE) correction through small volume correction (SVC) using a mask with regions that are functionally and structurally related to the DLPFC. A scatterplot of the relationship between the total scores on the PTGI and the delta-rGMV value from the significant peak voxel is shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037468&req=5

f2: (a) Regions that were correlated with the delta-rGMV values from the significant peak voxel. After controlling for sex, age, and total intracranial volume (TIV), the subscore for relating to others was positively associated with the delta- rGMV in the right dorsolateral prefrontal cortex (DLPFC) (x = 54, y = 38, z = 25; Threshold-free cluster enhancement [TFCE] = 3405.80, P = 0.027, k = 917), with a family-wise error (FWE) correction. A scatterplot of the relationship between the scores for relating to others and the delta-rGMV value from the significant peak voxel is shown. (b) Regions that were correlated with the delta-rGMV values from the significant peak voxel and total score on the PTGI. After controlling for sex, age, and TIV, the total score on the post-traumatic growth inventory (PTGI) was positively associated with the delta-rGMV in the right DLPFC (x = 54, y = 42, z = 22; Threshold-free cluster enhancement [TFCE] = 1376.47, P = 0.031, k = 504), with a family-wise error (FWE) correction through small volume correction (SVC) using a mask with regions that are functionally and structurally related to the DLPFC. A scatterplot of the relationship between the total scores on the PTGI and the delta-rGMV value from the significant peak voxel is shown.
Mentions: After controlling for sex; age; total intracranial volumes (TIV; total GMV+ total white matter volume [WMV]+ total cerebrospinal fluid volume); total scores on the RAPM, CAPS, and CES-D; score on the T-A subscale of the STAI at post; and the interval between the pre- and post-magnetic resonance imaging (MRI) data acquisitions, the whole-brain analysis revealed delta-rGMV in the right DLPFC was significantly correlated to the subscore for relating to others (x = 54, y = 38, z = 25; threshold-free cluster enhancement [TFCE] = 3,405.80, P = 0.027, k = 917, with family-wise error [FWE] correction) (Fig. 2a).

View Article: PubMed Central - PubMed

ABSTRACT

The relating to others factor of post-traumatic growth (PTG), which involves mutual help and a strong sense of connection with humanity, is important for young people who are coping with stress. The prefrontal cortex (PFC), especially the dorsolateral PFC (DLPFC), may play an important role in post-traumatic stress disorder (PTSD) with regard to coping and resilience. We hypothesized that the neural correlates of PTG may be responsible for resilience to the correlates of PTSD. Our study tested this hypothesis by examining whether measures of PTG, particularly the measures of relating to others after a disaster, were associated with increased regional grey matter volume (rGMV) in the PFC by assessing individuals who had experienced the East Japan Great Earthquake. We calculated the delta-rGMV by subtracting the rGMV obtained 3 months before the disaster from the rGMV obtained after this disaster using voxel-based morphometry. The magnetic resonance imaging data obtained from 26 subjects (M/F: 21/5; age: 21.2 ± 1.6 yrs.) showed that the total scores on a PTG inventory and the subscore for relating to others at the post-assessment were positively and significantly associated with the delta-rGMV in the right DLPFC. The DLPFC seems to be the main neural correlate of PTG.

No MeSH data available.