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Thickness of Actinic Keratosis Does Not Predict Dysplasia Severity or P53 Expression

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ABSTRACT

The severity of dysplasia and expression of p53 in actinic keratosis (AK) is of importance for the transformation to squamous cell carcinoma. It is assumed that it is most important to treat thick AKs as they are believed to be more dysplastic than thin AKs. However, a relation between AK thickness and dysplasia or the expression of p53 has never been demonstrated. The aim of this study was to investigate this possible relation. Sixty-six AKs were included for clinical and histological examination. Prior to performing a punch biopsy, the clinical thickness of each AK was measured objectively using two scale bars with a thickness of 0.5 mm and 1 mm. Subsequently, the thickness of the epidermis, the severity of dysplasia and the expression of p53 were assessed histologically. We found a strong and significant positive correlation between measured clinical thickness of the AKs and the histological thickness of epidermis (p < 0.0001). However, the clinical thickness did not correlate with either the severity of dysplasia (p = 0.7) or the expression of p53 (p = 0.5). In conclusion, thin AKs show the same severity of dysplasia and expression of p53 as thicker AK lesions. Consequently, clinical thickness cannot predict aggressiveness.

No MeSH data available.


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Severity of dysplasia, expression of p53 and clinical thickness.(a) Stacked bar chart of the severity of dysplasia (mild dysplasia coloured light grey, moderate dysplasia coloured dark grey and severe dysplasia coloured black) for the different categories of clinical thickness. We found no correlation between the severity of dysplasia and clinical thickness (p = 0.7). (b) Stacked bar chart of the expression of p53 (low expression of p53 coloured light grey and high expression of p53 coloured black) in the different categories of clinical thickness. We found no correlation between the expression of p53 and clinical thickness (p = 0.5).
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f3: Severity of dysplasia, expression of p53 and clinical thickness.(a) Stacked bar chart of the severity of dysplasia (mild dysplasia coloured light grey, moderate dysplasia coloured dark grey and severe dysplasia coloured black) for the different categories of clinical thickness. We found no correlation between the severity of dysplasia and clinical thickness (p = 0.7). (b) Stacked bar chart of the expression of p53 (low expression of p53 coloured light grey and high expression of p53 coloured black) in the different categories of clinical thickness. We found no correlation between the expression of p53 and clinical thickness (p = 0.5).

Mentions: Thirty AKs showed mild dysplasia, 23 showed moderate dysplasia and 13 showed severe dysplasia. Histopathological examples of mild, moderate and severe dysplasia are presented in Fig. 2. The severity of dysplasia in AKs with different clinical thickness is shown in Fig. 3a. We found no correlation between dysplasia severity and clinical thickness (p = 0.7).


Thickness of Actinic Keratosis Does Not Predict Dysplasia Severity or P53 Expression
Severity of dysplasia, expression of p53 and clinical thickness.(a) Stacked bar chart of the severity of dysplasia (mild dysplasia coloured light grey, moderate dysplasia coloured dark grey and severe dysplasia coloured black) for the different categories of clinical thickness. We found no correlation between the severity of dysplasia and clinical thickness (p = 0.7). (b) Stacked bar chart of the expression of p53 (low expression of p53 coloured light grey and high expression of p53 coloured black) in the different categories of clinical thickness. We found no correlation between the expression of p53 and clinical thickness (p = 0.5).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037398&req=5

f3: Severity of dysplasia, expression of p53 and clinical thickness.(a) Stacked bar chart of the severity of dysplasia (mild dysplasia coloured light grey, moderate dysplasia coloured dark grey and severe dysplasia coloured black) for the different categories of clinical thickness. We found no correlation between the severity of dysplasia and clinical thickness (p = 0.7). (b) Stacked bar chart of the expression of p53 (low expression of p53 coloured light grey and high expression of p53 coloured black) in the different categories of clinical thickness. We found no correlation between the expression of p53 and clinical thickness (p = 0.5).
Mentions: Thirty AKs showed mild dysplasia, 23 showed moderate dysplasia and 13 showed severe dysplasia. Histopathological examples of mild, moderate and severe dysplasia are presented in Fig. 2. The severity of dysplasia in AKs with different clinical thickness is shown in Fig. 3a. We found no correlation between dysplasia severity and clinical thickness (p = 0.7).

View Article: PubMed Central - PubMed

ABSTRACT

The severity of dysplasia and expression of p53 in actinic keratosis (AK) is of importance for the transformation to squamous cell carcinoma. It is assumed that it is most important to treat thick AKs as they are believed to be more dysplastic than thin AKs. However, a relation between AK thickness and dysplasia or the expression of p53 has never been demonstrated. The aim of this study was to investigate this possible relation. Sixty-six AKs were included for clinical and histological examination. Prior to performing a punch biopsy, the clinical thickness of each AK was measured objectively using two scale bars with a thickness of 0.5 mm and 1 mm. Subsequently, the thickness of the epidermis, the severity of dysplasia and the expression of p53 were assessed histologically. We found a strong and significant positive correlation between measured clinical thickness of the AKs and the histological thickness of epidermis (p < 0.0001). However, the clinical thickness did not correlate with either the severity of dysplasia (p = 0.7) or the expression of p53 (p = 0.5). In conclusion, thin AKs show the same severity of dysplasia and expression of p53 as thicker AK lesions. Consequently, clinical thickness cannot predict aggressiveness.

No MeSH data available.


Related in: MedlinePlus