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Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors

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ABSTRACT

To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas.Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6-to18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6-to18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.

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Total IgG and IgG, IgG1 and IgG3 concentrations specific to blood stage antigens in mothers and infants up to 18 months of age Antibody levels determined in: Ci: peripheral maternal blood; CO: cord blood; 3, 6, 9, 12, 15 and 18 months of infants’ age.The full line in the box represents median values. Also shown are 10, 25, 75 and 90% percentiles of the IgG, IgG1 and IgG3 concentrations specific for each malaria antigen. For each time point, the group size is: Ci: n = 525, CO: n = 525, 3: n = 374, 6: n = 384, 9: n = 409, 12: n = 418, 15: n = 431, 18: n = 442.
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f1: Total IgG and IgG, IgG1 and IgG3 concentrations specific to blood stage antigens in mothers and infants up to 18 months of age Antibody levels determined in: Ci: peripheral maternal blood; CO: cord blood; 3, 6, 9, 12, 15 and 18 months of infants’ age.The full line in the box represents median values. Also shown are 10, 25, 75 and 90% percentiles of the IgG, IgG1 and IgG3 concentrations specific for each malaria antigen. For each time point, the group size is: Ci: n = 525, CO: n = 525, 3: n = 374, 6: n = 384, 9: n = 409, 12: n = 418, 15: n = 431, 18: n = 442.

Mentions: The results presented in the Figs 1, 2 and 3 showed the raw data of IgG, IgG1 and IgG3 acquired in concentration (μg/mL) without statistical test associated.


Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors
Total IgG and IgG, IgG1 and IgG3 concentrations specific to blood stage antigens in mothers and infants up to 18 months of age Antibody levels determined in: Ci: peripheral maternal blood; CO: cord blood; 3, 6, 9, 12, 15 and 18 months of infants’ age.The full line in the box represents median values. Also shown are 10, 25, 75 and 90% percentiles of the IgG, IgG1 and IgG3 concentrations specific for each malaria antigen. For each time point, the group size is: Ci: n = 525, CO: n = 525, 3: n = 374, 6: n = 384, 9: n = 409, 12: n = 418, 15: n = 431, 18: n = 442.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037375&req=5

f1: Total IgG and IgG, IgG1 and IgG3 concentrations specific to blood stage antigens in mothers and infants up to 18 months of age Antibody levels determined in: Ci: peripheral maternal blood; CO: cord blood; 3, 6, 9, 12, 15 and 18 months of infants’ age.The full line in the box represents median values. Also shown are 10, 25, 75 and 90% percentiles of the IgG, IgG1 and IgG3 concentrations specific for each malaria antigen. For each time point, the group size is: Ci: n = 525, CO: n = 525, 3: n = 374, 6: n = 384, 9: n = 409, 12: n = 418, 15: n = 431, 18: n = 442.
Mentions: The results presented in the Figs 1, 2 and 3 showed the raw data of IgG, IgG1 and IgG3 acquired in concentration (μg/mL) without statistical test associated.

View Article: PubMed Central - PubMed

ABSTRACT

To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas.Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6-to18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6-to18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.

No MeSH data available.


Related in: MedlinePlus