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Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast

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ABSTRACT

Papillary carcinoma (PC) is a rare type of breast cancer, which comprises three histologic subtypes: encapsulated PC (EPC), solid PC (SPC) and invasive PC (IPC). Microarray-based gene expression and Affymetrix SNP 6.0 gene copy number profiling, and RNA-sequencing revealed that PCs are luminal breast cancers that display transcriptomic profiles distinct from those of grade- and estrogen receptor (ER)-matched invasive ductal carcinomas of no special type (IDC-NSTs), and that the papillary histologic pattern is unlikely to be underpinned by a highly recurrent expressed fusion gene or a highly recurrent expressed mutation. Despite displaying similar patterns of gene copy number alterations, significant differences in the transcriptomic profiles of EPCs, SPCs and IPCs were found, and may account for their different histologic features.

No MeSH data available.


Related in: MedlinePlus

Comparative genomic profiling of encapsulated, solid and invasive papillary carcinomas. Frequency plots and multi-Fisher's exact comparisons of chromosomal gains and losses in SPCs (top), IPCs (middle) and EPCs (bottom). The proportion of tumors in which each probe is gained (green bars) or lost (red bars) is plotted (y axis) for each probe, according to its genomic position (x axis). EPC, encapsulated papillary carcinoma; IPC, invasive papillary carcinoma; SPC, solid papillary carcinoma.
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fig6: Comparative genomic profiling of encapsulated, solid and invasive papillary carcinomas. Frequency plots and multi-Fisher's exact comparisons of chromosomal gains and losses in SPCs (top), IPCs (middle) and EPCs (bottom). The proportion of tumors in which each probe is gained (green bars) or lost (red bars) is plotted (y axis) for each probe, according to its genomic position (x axis). EPC, encapsulated papillary carcinoma; IPC, invasive papillary carcinoma; SPC, solid papillary carcinoma.

Mentions: Genomic analysis of EPCs, SPCs and IPCs revealed that these histologic subtypes of PCs have similar patterns of copy number losses, gains and amplifications (Figure 3, Figure 6), consistent with our previous observations (Duprez et al., 2012).


Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast
Comparative genomic profiling of encapsulated, solid and invasive papillary carcinomas. Frequency plots and multi-Fisher's exact comparisons of chromosomal gains and losses in SPCs (top), IPCs (middle) and EPCs (bottom). The proportion of tumors in which each probe is gained (green bars) or lost (red bars) is plotted (y axis) for each probe, according to its genomic position (x axis). EPC, encapsulated papillary carcinoma; IPC, invasive papillary carcinoma; SPC, solid papillary carcinoma.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5037246&req=5

fig6: Comparative genomic profiling of encapsulated, solid and invasive papillary carcinomas. Frequency plots and multi-Fisher's exact comparisons of chromosomal gains and losses in SPCs (top), IPCs (middle) and EPCs (bottom). The proportion of tumors in which each probe is gained (green bars) or lost (red bars) is plotted (y axis) for each probe, according to its genomic position (x axis). EPC, encapsulated papillary carcinoma; IPC, invasive papillary carcinoma; SPC, solid papillary carcinoma.
Mentions: Genomic analysis of EPCs, SPCs and IPCs revealed that these histologic subtypes of PCs have similar patterns of copy number losses, gains and amplifications (Figure 3, Figure 6), consistent with our previous observations (Duprez et al., 2012).

View Article: PubMed Central - PubMed

ABSTRACT

Papillary carcinoma (PC) is a rare type of breast cancer, which comprises three histologic subtypes: encapsulated PC (EPC), solid PC (SPC) and invasive PC (IPC). Microarray-based gene expression and Affymetrix SNP 6.0 gene copy number profiling, and RNA-sequencing revealed that PCs are luminal breast cancers that display transcriptomic profiles distinct from those of grade- and estrogen receptor (ER)-matched invasive ductal carcinomas of no special type (IDC-NSTs), and that the papillary histologic pattern is unlikely to be underpinned by a highly recurrent expressed fusion gene or a highly recurrent expressed mutation. Despite displaying similar patterns of gene copy number alterations, significant differences in the transcriptomic profiles of EPCs, SPCs and IPCs were found, and may account for their different histologic features.

No MeSH data available.


Related in: MedlinePlus