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An In vivo Multi-Modal Structural Template for Neonatal Piglets Using High Angular Resolution and Population-Based Whole-Brain Tractography

View Article: PubMed Central - PubMed

ABSTRACT

An increasing number of applications use the postnatal piglet model in neuroimaging studies, however, these are based primarily on T1 weighted image templates. There is a growing need for a multimodal structural brain template for a comprehensive depiction of the piglet brain, particularly given the growing applications of diffusion weighted imaging for characterizing tissue microstructures and white matter organization. In this study, we present the first multimodal piglet structural brain template which includes a T1 weighted image with tissue segmentation probability maps, diffusion weighted metric templates with multiple diffusivity maps, and population-based whole-brain fiber tracts for postnatal piglets. These maps provide information about the integrity of white matter that is not available in T1 images alone. The availability of this diffusion weighted metric template will contribute to the structural imaging analysis of the postnatal piglet brain, especially models that are designed for the study of white matter diseases. Furthermore, the population-based whole-brain fiber tracts permit researchers to visualize the white matter connections in the piglet brain across subjects, guiding the delineation of a specific white matter region for structural analysis where current diffusion data is lacking. Researchers are able to augment the tracts by merging tracts from their own data to the population-based fiber tracts and thus improve the confidence of the population-wise fiber distribution.

No MeSH data available.


Related in: MedlinePlus

Single subject T1 image (row 1) and template T1 image (row 2) are shown in the axial (Z = 5), sagittal (X = 5) and coronal (Y = 2) views. Rows 3∼5 show tissue probability maps for white matter (WM), gray matter (GM) and cerebrospinal fluid (CSF) in the template space.
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Figure 1: Single subject T1 image (row 1) and template T1 image (row 2) are shown in the axial (Z = 5), sagittal (X = 5) and coronal (Y = 2) views. Rows 3∼5 show tissue probability maps for white matter (WM), gray matter (GM) and cerebrospinal fluid (CSF) in the template space.

Mentions: The brain pattern is well preserved in the final T1 template brain compared to that of a single subject T1 image (Figure 1, row 1). The final T1 template brain is shown in Figure 1 (row 2) in the axial, coronal and sagittal views. Qualitatively, the outline of brain structures and GM/WM contrast are clearer in the template than in the single subject. Based on the intensity differences, the T1 brain image could be segmented into GM, WM and CSF. Figure 1, rows 3–5 shows the probability maps of GM, WM and CSF in the template space.


An In vivo Multi-Modal Structural Template for Neonatal Piglets Using High Angular Resolution and Population-Based Whole-Brain Tractography
Single subject T1 image (row 1) and template T1 image (row 2) are shown in the axial (Z = 5), sagittal (X = 5) and coronal (Y = 2) views. Rows 3∼5 show tissue probability maps for white matter (WM), gray matter (GM) and cerebrospinal fluid (CSF) in the template space.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037218&req=5

Figure 1: Single subject T1 image (row 1) and template T1 image (row 2) are shown in the axial (Z = 5), sagittal (X = 5) and coronal (Y = 2) views. Rows 3∼5 show tissue probability maps for white matter (WM), gray matter (GM) and cerebrospinal fluid (CSF) in the template space.
Mentions: The brain pattern is well preserved in the final T1 template brain compared to that of a single subject T1 image (Figure 1, row 1). The final T1 template brain is shown in Figure 1 (row 2) in the axial, coronal and sagittal views. Qualitatively, the outline of brain structures and GM/WM contrast are clearer in the template than in the single subject. Based on the intensity differences, the T1 brain image could be segmented into GM, WM and CSF. Figure 1, rows 3–5 shows the probability maps of GM, WM and CSF in the template space.

View Article: PubMed Central - PubMed

ABSTRACT

An increasing number of applications use the postnatal piglet model in neuroimaging studies, however, these are based primarily on T1 weighted image templates. There is a growing need for a multimodal structural brain template for a comprehensive depiction of the piglet brain, particularly given the growing applications of diffusion weighted imaging for characterizing tissue microstructures and white matter organization. In this study, we present the first multimodal piglet structural brain template which includes a T1 weighted image with tissue segmentation probability maps, diffusion weighted metric templates with multiple diffusivity maps, and population-based whole-brain fiber tracts for postnatal piglets. These maps provide information about the integrity of white matter that is not available in T1 images alone. The availability of this diffusion weighted metric template will contribute to the structural imaging analysis of the postnatal piglet brain, especially models that are designed for the study of white matter diseases. Furthermore, the population-based whole-brain fiber tracts permit researchers to visualize the white matter connections in the piglet brain across subjects, guiding the delineation of a specific white matter region for structural analysis where current diffusion data is lacking. Researchers are able to augment the tracts by merging tracts from their own data to the population-based fiber tracts and thus improve the confidence of the population-wise fiber distribution.

No MeSH data available.


Related in: MedlinePlus