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Lipocalin 2 (LCN2) Expression in Hepatic Malfunction and Therapy

View Article: PubMed Central - PubMed

ABSTRACT

Lipocalin 2 (LCN2) is a secreted protein that belongs to the Lipocalins, a group of transporters of small lipophilic molecules such as steroids, lipopolysaccharides, iron, and fatty acids in circulation. Two decades after its discovery and after a high variety of published findings, LCN2's altered expression has been assigned to critical roles in several pathological organ conditions, including liver injury and steatosis, renal damage, brain injury, cardiomyopathies, muscle-skeletal disorders, lung infection, and cancer in several organs. The significance of this 25-kDa lipocalin molecule has been impressively increased during the last years. Data from several studies indicate the role of LCN2 in physiological conditions as well as in response to cellular stress and injury. LCN2 in the liver shows a protective role in acute and chronic injury models where its expression is highly elevated. Moreover, LCN2 expression is being considered as a potential strong biomarker for pathological conditions, including rheumatic diseases, cancer in human organs, hepatic steatosis, hepatic damage, and inflammation. In this review, we summarize experimental and clinical findings linking LCN2 to the pathogenesis of liver disease.

No MeSH data available.


Related in: MedlinePlus

Association of LCN2 and LCN2R expression with conventional clinicopathological HCC parameters. An association study investigated the clinical significance of LCN2 and LCN2R in 138 patients who underwent curative resection of HCC. In conclusion, this study showed that the expression of both genes is correlated (r = 0.89; P < 0.001) and are up-regulated in HCC tissue and associated with vascular invasion status (P = 0.03) and TNM classification stage of malignant tumors (P = 0.004) that consider characteristics of the original primary tumor (T), the involved regional lymph nodes (N), and the occurrence of distant metastasis (M). In addition, the expression of both genes correlated well with tumor recurrence (P < 0.001), poor prognosis (P < 0.003), and overall survival rates (P < 0.001), suggesting that LCN2 and LCN2R expression are suitable prognostic factors and potential therapeutic targets in HCC. Details of this study are given elsewhere (Zhang et al., 2012).
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Figure 6: Association of LCN2 and LCN2R expression with conventional clinicopathological HCC parameters. An association study investigated the clinical significance of LCN2 and LCN2R in 138 patients who underwent curative resection of HCC. In conclusion, this study showed that the expression of both genes is correlated (r = 0.89; P < 0.001) and are up-regulated in HCC tissue and associated with vascular invasion status (P = 0.03) and TNM classification stage of malignant tumors (P = 0.004) that consider characteristics of the original primary tumor (T), the involved regional lymph nodes (N), and the occurrence of distant metastasis (M). In addition, the expression of both genes correlated well with tumor recurrence (P < 0.001), poor prognosis (P < 0.003), and overall survival rates (P < 0.001), suggesting that LCN2 and LCN2R expression are suitable prognostic factors and potential therapeutic targets in HCC. Details of this study are given elsewhere (Zhang et al., 2012).

Mentions: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide, leading to end-stage cirrhosis, and development of hepatocellular carcinoma (HCC). In 2010 urinary LCN2 levels were correlated to hepatic fibrosis and cirrhosis in HCV patients (Kim et al., 2010). Shortly after, an additional investigation demonstrated that LCN2 levels was elevated in HCC tissues and that both higher LCN2 and LCN2R expression correlated with shorter overall survival in HCC patients (Figure 6; Zhang et al., 2012).


Lipocalin 2 (LCN2) Expression in Hepatic Malfunction and Therapy
Association of LCN2 and LCN2R expression with conventional clinicopathological HCC parameters. An association study investigated the clinical significance of LCN2 and LCN2R in 138 patients who underwent curative resection of HCC. In conclusion, this study showed that the expression of both genes is correlated (r = 0.89; P < 0.001) and are up-regulated in HCC tissue and associated with vascular invasion status (P = 0.03) and TNM classification stage of malignant tumors (P = 0.004) that consider characteristics of the original primary tumor (T), the involved regional lymph nodes (N), and the occurrence of distant metastasis (M). In addition, the expression of both genes correlated well with tumor recurrence (P < 0.001), poor prognosis (P < 0.003), and overall survival rates (P < 0.001), suggesting that LCN2 and LCN2R expression are suitable prognostic factors and potential therapeutic targets in HCC. Details of this study are given elsewhere (Zhang et al., 2012).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037186&req=5

Figure 6: Association of LCN2 and LCN2R expression with conventional clinicopathological HCC parameters. An association study investigated the clinical significance of LCN2 and LCN2R in 138 patients who underwent curative resection of HCC. In conclusion, this study showed that the expression of both genes is correlated (r = 0.89; P < 0.001) and are up-regulated in HCC tissue and associated with vascular invasion status (P = 0.03) and TNM classification stage of malignant tumors (P = 0.004) that consider characteristics of the original primary tumor (T), the involved regional lymph nodes (N), and the occurrence of distant metastasis (M). In addition, the expression of both genes correlated well with tumor recurrence (P < 0.001), poor prognosis (P < 0.003), and overall survival rates (P < 0.001), suggesting that LCN2 and LCN2R expression are suitable prognostic factors and potential therapeutic targets in HCC. Details of this study are given elsewhere (Zhang et al., 2012).
Mentions: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide, leading to end-stage cirrhosis, and development of hepatocellular carcinoma (HCC). In 2010 urinary LCN2 levels were correlated to hepatic fibrosis and cirrhosis in HCV patients (Kim et al., 2010). Shortly after, an additional investigation demonstrated that LCN2 levels was elevated in HCC tissues and that both higher LCN2 and LCN2R expression correlated with shorter overall survival in HCC patients (Figure 6; Zhang et al., 2012).

View Article: PubMed Central - PubMed

ABSTRACT

Lipocalin 2 (LCN2) is a secreted protein that belongs to the Lipocalins, a group of transporters of small lipophilic molecules such as steroids, lipopolysaccharides, iron, and fatty acids in circulation. Two decades after its discovery and after a high variety of published findings, LCN2's altered expression has been assigned to critical roles in several pathological organ conditions, including liver injury and steatosis, renal damage, brain injury, cardiomyopathies, muscle-skeletal disorders, lung infection, and cancer in several organs. The significance of this 25-kDa lipocalin molecule has been impressively increased during the last years. Data from several studies indicate the role of LCN2 in physiological conditions as well as in response to cellular stress and injury. LCN2 in the liver shows a protective role in acute and chronic injury models where its expression is highly elevated. Moreover, LCN2 expression is being considered as a potential strong biomarker for pathological conditions, including rheumatic diseases, cancer in human organs, hepatic steatosis, hepatic damage, and inflammation. In this review, we summarize experimental and clinical findings linking LCN2 to the pathogenesis of liver disease.

No MeSH data available.


Related in: MedlinePlus