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Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study

View Article: PubMed Central - PubMed

ABSTRACT

Background: The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI).

Methods: Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC).

Results: Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group.

Conclusion: This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation.

No MeSH data available.


Double neuromodulation network of MrD including three order pain generator network and three order pain complementary networkᅟ
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Fig4: Double neuromodulation network of MrD including three order pain generator network and three order pain complementary networkᅟ

Mentions: The decreased functional connectivity of MrD was detected in the left precentral gyrus, the triangular part of the inferior frontal gyrus, the insula, the right medial superior frontal gyrus, and the superior frontal gyrus, and increased functional connectivity was observed in the left superior temporal gyrus, hippocampus, thalamus, and right middle cingulum in the MOH + CM group compared with the CM group (Fig. 3, 4).Fig. 4


Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study
Double neuromodulation network of MrD including three order pain generator network and three order pain complementary networkᅟ
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037100&req=5

Fig4: Double neuromodulation network of MrD including three order pain generator network and three order pain complementary networkᅟ
Mentions: The decreased functional connectivity of MrD was detected in the left precentral gyrus, the triangular part of the inferior frontal gyrus, the insula, the right medial superior frontal gyrus, and the superior frontal gyrus, and increased functional connectivity was observed in the left superior temporal gyrus, hippocampus, thalamus, and right middle cingulum in the MOH + CM group compared with the CM group (Fig. 3, 4).Fig. 4

View Article: PubMed Central - PubMed

ABSTRACT

Background: The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI).

Methods: Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC).

Results: Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group.

Conclusion: This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation.

No MeSH data available.