Limits...
Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study

View Article: PubMed Central - PubMed

ABSTRACT

Background: The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI).

Methods: Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC).

Results: Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group.

Conclusion: This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation.

No MeSH data available.


Related in: MedlinePlus

Comparison of MrD functional connectivity among subjects group. Warm color represents decreased MrD functional connectivity in EM compared with NC, and cool color represent increased MrD functional connectivity. NC, normal control; EM, episodic migraine; CM, chronic migraine; MOH+CM, medication overuse headache plus chronic migraine; MrD, marginal division
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC5037100&req=5

Fig3: Comparison of MrD functional connectivity among subjects group. Warm color represents decreased MrD functional connectivity in EM compared with NC, and cool color represent increased MrD functional connectivity. NC, normal control; EM, episodic migraine; CM, chronic migraine; MOH+CM, medication overuse headache plus chronic migraine; MrD, marginal division

Mentions: Table 2 shows the altered functional connectivity of MrD in migraineurs compared with NCs. In the EM group, the brain regions with decreased functional connectivity were mainly located in the right insula, and the brain regions with increased functional connectivity were mainly located in the right precentral gyrus and anterior cingulate cortex (ACC) (Fig. 3). In the CM group, the decreased functional connectivity of MrD was observed in the right cuneus and left middle cingulum cortex (MCC), and the increased functional connectivity was detected in the bilateral middle frontal gyrus, left hippocampus, and middle temporal gyrus (Fig. 3).Table 2


Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study
Comparison of MrD functional connectivity among subjects group. Warm color represents decreased MrD functional connectivity in EM compared with NC, and cool color represent increased MrD functional connectivity. NC, normal control; EM, episodic migraine; CM, chronic migraine; MOH+CM, medication overuse headache plus chronic migraine; MrD, marginal division
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037100&req=5

Fig3: Comparison of MrD functional connectivity among subjects group. Warm color represents decreased MrD functional connectivity in EM compared with NC, and cool color represent increased MrD functional connectivity. NC, normal control; EM, episodic migraine; CM, chronic migraine; MOH+CM, medication overuse headache plus chronic migraine; MrD, marginal division
Mentions: Table 2 shows the altered functional connectivity of MrD in migraineurs compared with NCs. In the EM group, the brain regions with decreased functional connectivity were mainly located in the right insula, and the brain regions with increased functional connectivity were mainly located in the right precentral gyrus and anterior cingulate cortex (ACC) (Fig. 3). In the CM group, the decreased functional connectivity of MrD was observed in the right cuneus and left middle cingulum cortex (MCC), and the increased functional connectivity was detected in the bilateral middle frontal gyrus, left hippocampus, and middle temporal gyrus (Fig. 3).Table 2

View Article: PubMed Central - PubMed

ABSTRACT

Background: The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI).

Methods: Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC).

Results: Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group.

Conclusion: This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation.

No MeSH data available.


Related in: MedlinePlus