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Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study

View Article: PubMed Central - PubMed

ABSTRACT

Background: The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI).

Methods: Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC).

Results: Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group.

Conclusion: This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation.

No MeSH data available.


Related in: MedlinePlus

MrD functional connectivity averaged over subject in the brain. Warm and cool colors represent positive and negative correlations. NC, normal control; EM, episodic migraine; CM, chronic migraine; MOH+CM, medication overuse headache plus chronic migraine;L, left MrD; R, right MrD
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Fig2: MrD functional connectivity averaged over subject in the brain. Warm and cool colors represent positive and negative correlations. NC, normal control; EM, episodic migraine; CM, chronic migraine; MOH+CM, medication overuse headache plus chronic migraine;L, left MrD; R, right MrD

Mentions: Regions with positive functional connectivity of MrD were mainly in the bilateral basal ganglion regions, thalamus, insula, hippocampus, and right medial frontal orbital cortex, and the regions of negative functional connectivity of MrD were in the bilateral temporal lobes and middle frontal lobes in the NC group (Fig. 2).Fig. 2


Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study
MrD functional connectivity averaged over subject in the brain. Warm and cool colors represent positive and negative correlations. NC, normal control; EM, episodic migraine; CM, chronic migraine; MOH+CM, medication overuse headache plus chronic migraine;L, left MrD; R, right MrD
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5037100&req=5

Fig2: MrD functional connectivity averaged over subject in the brain. Warm and cool colors represent positive and negative correlations. NC, normal control; EM, episodic migraine; CM, chronic migraine; MOH+CM, medication overuse headache plus chronic migraine;L, left MrD; R, right MrD
Mentions: Regions with positive functional connectivity of MrD were mainly in the bilateral basal ganglion regions, thalamus, insula, hippocampus, and right medial frontal orbital cortex, and the regions of negative functional connectivity of MrD were in the bilateral temporal lobes and middle frontal lobes in the NC group (Fig. 2).Fig. 2

View Article: PubMed Central - PubMed

ABSTRACT

Background: The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI).

Methods: Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC).

Results: Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group.

Conclusion: This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation.

No MeSH data available.


Related in: MedlinePlus