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Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study

View Article: PubMed Central - PubMed

ABSTRACT

Background: The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI).

Methods: Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC).

Results: Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group.

Conclusion: This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation.

No MeSH data available.


Bilateral marginal divison was created by manual drawing based on ch2bet template in MRIcron software
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Fig1: Bilateral marginal divison was created by manual drawing based on ch2bet template in MRIcron software

Mentions: The functional connectivity analysis was performed as follows: (1) Spatial smooth (full width at half maximum (FWHM) = 6 mm) using SPM8; (2) MrD was defined using manual delineation on a ch2bet template in MRIcron software (v6.6, www.mricro.com) (Fig. 1); (3) Functional connectivity computation of the left and right MrD were performed using REST (v1.8). The time courses of bilateral MrD were extracted, and Pearson’s correlations were used to calculate the functional connectivity between the extracted time courses and the averaged time courses of the whole brain in a voxel-wise manner. The white matter, cerebrospinal fluid (CSF), and the six head motion parameters were used as covariates. (4) The individual r-maps were normalized to Z-maps using Fisher’s Z-transformation.Fig. 1


Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study
Bilateral marginal divison was created by manual drawing based on ch2bet template in MRIcron software
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037100&req=5

Fig1: Bilateral marginal divison was created by manual drawing based on ch2bet template in MRIcron software
Mentions: The functional connectivity analysis was performed as follows: (1) Spatial smooth (full width at half maximum (FWHM) = 6 mm) using SPM8; (2) MrD was defined using manual delineation on a ch2bet template in MRIcron software (v6.6, www.mricro.com) (Fig. 1); (3) Functional connectivity computation of the left and right MrD were performed using REST (v1.8). The time courses of bilateral MrD were extracted, and Pearson’s correlations were used to calculate the functional connectivity between the extracted time courses and the averaged time courses of the whole brain in a voxel-wise manner. The white matter, cerebrospinal fluid (CSF), and the six head motion parameters were used as covariates. (4) The individual r-maps were normalized to Z-maps using Fisher’s Z-transformation.Fig. 1

View Article: PubMed Central - PubMed

ABSTRACT

Background: The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI).

Methods: Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC).

Results: Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group.

Conclusion: This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation.

No MeSH data available.