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Size effect of Au/PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue

View Article: PubMed Central - PubMed

ABSTRACT

Polyamidoamine (PAMAM)-entrapped Au nanoparticles were synthesized with distinct sizes to figure out the size effect of Au-based contrast agent on CT imaging of passively targeted tissues. Au/PAMAM nanoparticles were first synthesized with narrow distribution of particles size of 22.2 ± 3.1, 54.2 ± 3.7, and 104.9 ± 4.7 nm in diameters. Size effect leads no significant difference on X-ray attenuation when Au/PAMAM was ≤0.05 mol/L. For CT imaging of a tumor model, small Au/PAMAM were more easily internalized via endocytosis in the liver, leading to more obviously enhanced contrast. Similarly, contrast agents with small sizes were more effective in tumor imaging because of the enhanced permeability and retention effect. Overall, the particle size of Au/PAMAM heavily affected the efficiency of CT enhancement in imaging RES and tumors.

No MeSH data available.


Au/PAMAM lead X-ray attenuation depending on concentration and particle size. The curve of HU values without significant difference were circled in the orange box and amplified in the upper left corner
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Fig2: Au/PAMAM lead X-ray attenuation depending on concentration and particle size. The curve of HU values without significant difference were circled in the orange box and amplified in the upper left corner

Mentions: As depicted in Fig. 2, Au/PAMAM had a linearly increased enhancing effect on X-ray attenuation relied on the concentration of contrast agents. As shown in the amplified graph, size did not lead to a significant difference on X-ray attenuation for contrast agents with concentration ≤0.05 mol/L.Fig. 2


Size effect of Au/PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue
Au/PAMAM lead X-ray attenuation depending on concentration and particle size. The curve of HU values without significant difference were circled in the orange box and amplified in the upper left corner
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037097&req=5

Fig2: Au/PAMAM lead X-ray attenuation depending on concentration and particle size. The curve of HU values without significant difference were circled in the orange box and amplified in the upper left corner
Mentions: As depicted in Fig. 2, Au/PAMAM had a linearly increased enhancing effect on X-ray attenuation relied on the concentration of contrast agents. As shown in the amplified graph, size did not lead to a significant difference on X-ray attenuation for contrast agents with concentration ≤0.05 mol/L.Fig. 2

View Article: PubMed Central - PubMed

ABSTRACT

Polyamidoamine (PAMAM)-entrapped Au nanoparticles were synthesized with distinct sizes to figure out the size effect of Au-based contrast agent on CT imaging of passively targeted tissues. Au/PAMAM nanoparticles were first synthesized with narrow distribution of particles size of 22.2 ± 3.1, 54.2 ± 3.7, and 104.9 ± 4.7 nm in diameters. Size effect leads no significant difference on X-ray attenuation when Au/PAMAM was ≤0.05 mol/L. For CT imaging of a tumor model, small Au/PAMAM were more easily internalized via endocytosis in the liver, leading to more obviously enhanced contrast. Similarly, contrast agents with small sizes were more effective in tumor imaging because of the enhanced permeability and retention effect. Overall, the particle size of Au/PAMAM heavily affected the efficiency of CT enhancement in imaging RES and tumors.

No MeSH data available.