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Korean Curcuma longa L . induces lipolysis and regulates leptin in adipocyte cells and rats

View Article: PubMed Central - PubMed

ABSTRACT

Background/objectives: Turmeric (Curcuma longa L.) has been reported to have many biological functions including anti-obesity. Leptin, peptide hormone produced by adipocytes and its concentration is increased in proportion to the amount of the adipocytes. In the present study, we examined the effects of Korean turmeric on the regulation of adiposity and leptin levels in 3T3-L1 adipocytes and rats fed a high-fat and high-cholesterol diet.

Materials/methods: Leptin secretion, free fatty acid and glycerol contents in 3T3-L1 adipocytes were measured after incubation of cells with turmeric for 24 hours. Rats were divided into four experimental groups: a normal diet group (N), a high-fat and high-cholesterol diet group (HF), a high-fat and high-cholesterol diet group supplemented with 2.5% turmeric extracts (TPA group) and a high-fat and high-cholesterol diet group supplemented with 5% turmeric extracts (TPB group). Serum samples were used for the measurement of leptin concentration.

Results: Contents of free fatty acid and glycerol showed concentration dependent increase in response to turmeric extracts. Effects of turmeric extracts on reduction of lipid accumulation in 3T3-L1 cells were examined by Oil Red O staining. Treatment with turmeric extracts resulted in increased expression levels of adipose triglyceride lipase and hormone-sensitive lipase mRNA. The concentration of leptin from 3T3-L1 adipocytes was significantly decreased by turmeric. Proportional abdominal and epididymal fats weights of the turmeric 5% supplemented group, TPB has significantly decreased compared to the HF group. The serum levels of leptin in the TPA and TPB groups were significantly lower than those of the HF group.

Conclusions: Based on these results, we suggested that Korean turmeric may contribute to the decreasing of body fat and regulating leptin secretion.

No MeSH data available.


Related in: MedlinePlus

Effects of turmeric extracts on serum leptin of rats fed high-fat and high-cholesterol diets.The secretion of leptin from serum of rats fed normal diet (N), high-fat and high-cholesterol diet (HF) and high-fat and high-cholesterol diet with turmeric extracts 2.5% (TPA) or 5% (TPB) diets for 4 weeks. All values are the means ± SE (n = 10). Those with different superscript letters are significantly different at P < 0.05 by Tukey's test.
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Figure 6: Effects of turmeric extracts on serum leptin of rats fed high-fat and high-cholesterol diets.The secretion of leptin from serum of rats fed normal diet (N), high-fat and high-cholesterol diet (HF) and high-fat and high-cholesterol diet with turmeric extracts 2.5% (TPA) or 5% (TPB) diets for 4 weeks. All values are the means ± SE (n = 10). Those with different superscript letters are significantly different at P < 0.05 by Tukey's test.

Mentions: Fig. 6 shows change of leptin levels in the rats serum by turmeric. The result of leptin in the serum was greater in the HF, TPA and TPB groups than in the N group. The leptin in the TPA and TPB was 26.4% and 38.7% lower, respectively, than that in the HF group. Especially, TPB group showed the control of leptin secretion to the normal extent. These results indicate that turmeric is able to regulate secretion of leptin.


Korean Curcuma longa L . induces lipolysis and regulates leptin in adipocyte cells and rats
Effects of turmeric extracts on serum leptin of rats fed high-fat and high-cholesterol diets.The secretion of leptin from serum of rats fed normal diet (N), high-fat and high-cholesterol diet (HF) and high-fat and high-cholesterol diet with turmeric extracts 2.5% (TPA) or 5% (TPB) diets for 4 weeks. All values are the means ± SE (n = 10). Those with different superscript letters are significantly different at P < 0.05 by Tukey's test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037065&req=5

Figure 6: Effects of turmeric extracts on serum leptin of rats fed high-fat and high-cholesterol diets.The secretion of leptin from serum of rats fed normal diet (N), high-fat and high-cholesterol diet (HF) and high-fat and high-cholesterol diet with turmeric extracts 2.5% (TPA) or 5% (TPB) diets for 4 weeks. All values are the means ± SE (n = 10). Those with different superscript letters are significantly different at P < 0.05 by Tukey's test.
Mentions: Fig. 6 shows change of leptin levels in the rats serum by turmeric. The result of leptin in the serum was greater in the HF, TPA and TPB groups than in the N group. The leptin in the TPA and TPB was 26.4% and 38.7% lower, respectively, than that in the HF group. Especially, TPB group showed the control of leptin secretion to the normal extent. These results indicate that turmeric is able to regulate secretion of leptin.

View Article: PubMed Central - PubMed

ABSTRACT

Background/objectives: Turmeric (Curcuma longa L.) has been reported to have many biological functions including anti-obesity. Leptin, peptide hormone produced by adipocytes and its concentration is increased in proportion to the amount of the adipocytes. In the present study, we examined the effects of Korean turmeric on the regulation of adiposity and leptin levels in 3T3-L1 adipocytes and rats fed a high-fat and high-cholesterol diet.

Materials/methods: Leptin secretion, free fatty acid and glycerol contents in 3T3-L1 adipocytes were measured after incubation of cells with turmeric for 24 hours. Rats were divided into four experimental groups: a normal diet group (N), a high-fat and high-cholesterol diet group (HF), a high-fat and high-cholesterol diet group supplemented with 2.5% turmeric extracts (TPA group) and a high-fat and high-cholesterol diet group supplemented with 5% turmeric extracts (TPB group). Serum samples were used for the measurement of leptin concentration.

Results: Contents of free fatty acid and glycerol showed concentration dependent increase in response to turmeric extracts. Effects of turmeric extracts on reduction of lipid accumulation in 3T3-L1 cells were examined by Oil Red O staining. Treatment with turmeric extracts resulted in increased expression levels of adipose triglyceride lipase and hormone-sensitive lipase mRNA. The concentration of leptin from 3T3-L1 adipocytes was significantly decreased by turmeric. Proportional abdominal and epididymal fats weights of the turmeric 5% supplemented group, TPB has significantly decreased compared to the HF group. The serum levels of leptin in the TPA and TPB groups were significantly lower than those of the HF group.

Conclusions: Based on these results, we suggested that Korean turmeric may contribute to the decreasing of body fat and regulating leptin secretion.

No MeSH data available.


Related in: MedlinePlus