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Chronic Pulmonary Histoplasmosis and its Clinical Significance: an Under-reported Systemic Fungal Disease

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ABSTRACT

Histoplasmosis is a systemic fungal mycosis caused by Histoplasmacapsulatum. It is a dimorphic fungus which lives as a saprophyte in the environment and occasionally infects immunosuppressed people. H capsulatum is a ubiquitous fungus present throughout the globe and is more common in the temperate world. Human infection with H capsulatum occurs through respiratory route by inhalation of spores present in the air as droplet nuclei. Pulmonary histoplasmosis is difficult to diagnose, more so in the regions where tuberculosis is endemic, and many infected patients remain asymptomatic. In the case of immunosuppression, clinical symptoms of pulmonary infection may be seen along with chances of dissemination. We report a case of chronic pulmonary histoplasmosis in an immunocompetent individual.

No MeSH data available.


Sabourauds dextrose agar showing growth of whitish, buff colonies of Histoplasma capsulatum
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FIG2: Sabourauds dextrose agar showing growth of whitish, buff colonies of Histoplasma capsulatum

Mentions: Mycobacterial culture was negative after incubation for eight weeks. The fungal culture was maintained at room temperature and after two weeks revealed the growth of whitish, buff colonies which developed a central light-brownish pigmentation on further incubation as shown in Figure 2.


Chronic Pulmonary Histoplasmosis and its Clinical Significance: an Under-reported Systemic Fungal Disease
Sabourauds dextrose agar showing growth of whitish, buff colonies of Histoplasma capsulatum
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037059&req=5

FIG2: Sabourauds dextrose agar showing growth of whitish, buff colonies of Histoplasma capsulatum
Mentions: Mycobacterial culture was negative after incubation for eight weeks. The fungal culture was maintained at room temperature and after two weeks revealed the growth of whitish, buff colonies which developed a central light-brownish pigmentation on further incubation as shown in Figure 2.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Histoplasmosis is a systemic fungal mycosis caused by Histoplasmacapsulatum. It is a dimorphic fungus which lives as a saprophyte in the environment and occasionally infects immunosuppressed people. H capsulatum is a ubiquitous fungus present throughout the globe and is more common in the temperate world. Human infection with H capsulatum occurs through respiratory route by inhalation of spores present in the air as droplet nuclei. Pulmonary histoplasmosis is difficult to diagnose, more so in the regions where tuberculosis is endemic, and many infected patients remain asymptomatic. In the case of immunosuppression, clinical symptoms of pulmonary infection may be seen along with chances of dissemination. We report a case of chronic pulmonary histoplasmosis in an immunocompetent individual.

No MeSH data available.