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Chronic Pulmonary Histoplasmosis and its Clinical Significance: an Under-reported Systemic Fungal Disease

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ABSTRACT

Histoplasmosis is a systemic fungal mycosis caused by Histoplasmacapsulatum. It is a dimorphic fungus which lives as a saprophyte in the environment and occasionally infects immunosuppressed people. H capsulatum is a ubiquitous fungus present throughout the globe and is more common in the temperate world. Human infection with H capsulatum occurs through respiratory route by inhalation of spores present in the air as droplet nuclei. Pulmonary histoplasmosis is difficult to diagnose, more so in the regions where tuberculosis is endemic, and many infected patients remain asymptomatic. In the case of immunosuppression, clinical symptoms of pulmonary infection may be seen along with chances of dissemination. We report a case of chronic pulmonary histoplasmosis in an immunocompetent individual.

No MeSH data available.


Appearance of acid-fast structures on Ziehl-Neelsen’s stain
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FIG1: Appearance of acid-fast structures on Ziehl-Neelsen’s stain

Mentions: A chest x-ray revealed multiple nodular lesions. Gram’s stain showed one to two pus cells per high power field and no bacteria. Routine culture revealed no pathogenic bacteria. Ziehl-Neelsen’s stain was negative for acid-fast bacilli but was showing the presence of spherical shaped acid-fast structures as shown in Figure 1.


Chronic Pulmonary Histoplasmosis and its Clinical Significance: an Under-reported Systemic Fungal Disease
Appearance of acid-fast structures on Ziehl-Neelsen’s stain
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5037059&req=5

FIG1: Appearance of acid-fast structures on Ziehl-Neelsen’s stain
Mentions: A chest x-ray revealed multiple nodular lesions. Gram’s stain showed one to two pus cells per high power field and no bacteria. Routine culture revealed no pathogenic bacteria. Ziehl-Neelsen’s stain was negative for acid-fast bacilli but was showing the presence of spherical shaped acid-fast structures as shown in Figure 1.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Histoplasmosis is a systemic fungal mycosis caused by Histoplasmacapsulatum. It is a dimorphic fungus which lives as a saprophyte in the environment and occasionally infects immunosuppressed people. H capsulatum is a ubiquitous fungus present throughout the globe and is more common in the temperate world. Human infection with H capsulatum occurs through respiratory route by inhalation of spores present in the air as droplet nuclei. Pulmonary histoplasmosis is difficult to diagnose, more so in the regions where tuberculosis is endemic, and many infected patients remain asymptomatic. In the case of immunosuppression, clinical symptoms of pulmonary infection may be seen along with chances of dissemination. We report a case of chronic pulmonary histoplasmosis in an immunocompetent individual.

No MeSH data available.