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Quantitative 3D magnetic resonance elastography: Comparison with dynamic mechanical analysis

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ABSTRACT

Purpose: Magnetic resonance elastography (MRE) is a rapidly growing noninvasive imaging technique for measuring tissue mechanical properties in vivo. Previous studies have compared two‐dimensional MRE measurements with material properties from dynamic mechanical analysis (DMA) devices that were limited in frequency range. Advanced DMA technology now allows broad frequency range testing, and three‐dimensional (3D) MRE is increasingly common. The purpose of this study was to compare 3D MRE stiffness measurements with those of DMA over a wide range of frequencies and shear stiffnesses.

Methods: 3D MRE and DMA were performed on eight different polyvinyl chloride samples over 20–205 Hz with stiffness between 3 and 23 kPa. Driving frequencies were chosen to create 1.1, 2.2, 3.3, 4.4, 5.5, and 6.6 effective wavelengths across the diameter of the cylindrical phantoms. Wave images were analyzed using direct inversion and local frequency estimation algorithm with the curl operator and compared with DMA measurements at each corresponding frequency. Samples with sufficient spatial resolution and with an octahedral shear strain signal‐to‐noise ratio > 3 were compared.

Results: Consistency between the two techniques was measured with the intraclass correlation coefficient (ICC) and was excellent with an overall ICC of 0.99.

Conclusions: 3D MRE and DMA showed excellent consistency over a wide range of frequencies and stiffnesses. Magn Reson Med 77:1184–1192, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

No MeSH data available.


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Plot of DMA versus MRE LFE shear stiffness. The dotted line is the line of unity. ICC = 0.99 (95% CI = 0.97–0.99).
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mrm26207-fig-0008: Plot of DMA versus MRE LFE shear stiffness. The dotted line is the line of unity. ICC = 0.99 (95% CI = 0.97–0.99).

Mentions: Consistency of the shear stiffness estimated using 3D LFE and DMA was also excellent, similar to the ICC estimation for the magnitude of the complex shear modulus with ICC = 0.99 (95% CI = 0.97–0.99). Figure 8 shows the plot between MRE LFE and DMA shear stiffness in kPa across all frequencies for these data sets.


Quantitative 3D magnetic resonance elastography: Comparison with dynamic mechanical analysis
Plot of DMA versus MRE LFE shear stiffness. The dotted line is the line of unity. ICC = 0.99 (95% CI = 0.97–0.99).
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Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC5036985&req=5

mrm26207-fig-0008: Plot of DMA versus MRE LFE shear stiffness. The dotted line is the line of unity. ICC = 0.99 (95% CI = 0.97–0.99).
Mentions: Consistency of the shear stiffness estimated using 3D LFE and DMA was also excellent, similar to the ICC estimation for the magnitude of the complex shear modulus with ICC = 0.99 (95% CI = 0.97–0.99). Figure 8 shows the plot between MRE LFE and DMA shear stiffness in kPa across all frequencies for these data sets.

View Article: PubMed Central - PubMed

ABSTRACT

Purpose: Magnetic resonance elastography (MRE) is a rapidly growing noninvasive imaging technique for measuring tissue mechanical properties in vivo. Previous studies have compared two‐dimensional MRE measurements with material properties from dynamic mechanical analysis (DMA) devices that were limited in frequency range. Advanced DMA technology now allows broad frequency range testing, and three‐dimensional (3D) MRE is increasingly common. The purpose of this study was to compare 3D MRE stiffness measurements with those of DMA over a wide range of frequencies and shear stiffnesses.

Methods: 3D MRE and DMA were performed on eight different polyvinyl chloride samples over 20–205 Hz with stiffness between 3 and 23 kPa. Driving frequencies were chosen to create 1.1, 2.2, 3.3, 4.4, 5.5, and 6.6 effective wavelengths across the diameter of the cylindrical phantoms. Wave images were analyzed using direct inversion and local frequency estimation algorithm with the curl operator and compared with DMA measurements at each corresponding frequency. Samples with sufficient spatial resolution and with an octahedral shear strain signal‐to‐noise ratio > 3 were compared.

Results: Consistency between the two techniques was measured with the intraclass correlation coefficient (ICC) and was excellent with an overall ICC of 0.99.

Conclusions: 3D MRE and DMA showed excellent consistency over a wide range of frequencies and stiffnesses. Magn Reson Med 77:1184–1192, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

No MeSH data available.


Related in: MedlinePlus