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Relevance Study on Cerebral Infarction and Resistin Gene Polymorphism in Chinese Han Population

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ABSTRACT

Recent research on genome-wide associations has implicated that the serum resistin level and its gene polymorphism are associated with cerebral infarction (CI) morbidity and prognosis, and could thereby regulate CI. This study aimed to investigate the association between the resistin single nucleotide polymorphism (SNP) and the susceptibility to CI in the Chinese Han population. A total of 550 CI patients and 313 healthy controls were genotyped. Nine SNPs of the resistin gene previously shown were sequenced and assessed for an association with CI. The numbers of GG genotype carriers of rs3219175 and rs3486119 in the CI group were significantly higher than those in the control group among the middle-aged group (aged 45-65), at 76% vs 67.9% (P=0.025) and 75.5% vs 67.9% (P=0.031). rs3219175 and rs34861192 were associated with CI in the dominant and superdominant models according to the genetic model analysis (P<0.05). Meanwhile, there was strong linkage disequilibrium among the rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369 sites. In a haplotype analysis, the occurrence rate of the haplotype AGGCAGC was 1.97 times (P<0.05) higher in the patient group than in the control group. In addition, the numbers of GG genotype carriers of rs3219175 and rs3486119 in the middle-aged male CI patients and the middle-aged small artery occlusion (SAO) CI patients were higher than those in the control group (P<0.05). In the Chinese Han middle-aged population, the GG gene type carriers of the resistin gene sites rs3219175 and rs34861192 had a high risk for CI onset, especially in middle-aged male patients and SAO CI in all middle-aged patients.

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Related in: MedlinePlus

LD analysis of 9 SNPs (subjects aged 45-65). The LD structure was analyzed by Haploview for a total of 634 alleles from the patients with cerebral infarction and from the controls. There was a strong LD between the rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369 (red box) polymorphisms with a standardized disequilibrium coefficient (D’ >0.7).
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F1-ad-7-5-593: LD analysis of 9 SNPs (subjects aged 45-65). The LD structure was analyzed by Haploview for a total of 634 alleles from the patients with cerebral infarction and from the controls. There was a strong LD between the rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369 (red box) polymorphisms with a standardized disequilibrium coefficient (D’ >0.7).

Mentions: As for the complex diseases caused by multi-genes, the function of single gene sites could be minute; thus, linkage analysis of multiple genes is necessary[33]. According to the LD coefficient D’ among the 9 SNPs, strong LD existed among the seven SNPs (rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369) (D’>0.7) (Figure 1). Therefore, haplotype analysis needed to be performed. The haplotype of RETN SNPs rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369 (AGGCAGC) in the CI group had a 1.97 times higher occurrence rate than that in the control group (95% CI 1.07-3.60, P=0.026). In addition, the occurrence of CI also increased significantly. However, no evident or significant differences were observed between the CI group and the control group for the other 7 haplotypes (Table 5).


Relevance Study on Cerebral Infarction and Resistin Gene Polymorphism in Chinese Han Population
LD analysis of 9 SNPs (subjects aged 45-65). The LD structure was analyzed by Haploview for a total of 634 alleles from the patients with cerebral infarction and from the controls. There was a strong LD between the rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369 (red box) polymorphisms with a standardized disequilibrium coefficient (D’ >0.7).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036954&req=5

F1-ad-7-5-593: LD analysis of 9 SNPs (subjects aged 45-65). The LD structure was analyzed by Haploview for a total of 634 alleles from the patients with cerebral infarction and from the controls. There was a strong LD between the rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369 (red box) polymorphisms with a standardized disequilibrium coefficient (D’ >0.7).
Mentions: As for the complex diseases caused by multi-genes, the function of single gene sites could be minute; thus, linkage analysis of multiple genes is necessary[33]. According to the LD coefficient D’ among the 9 SNPs, strong LD existed among the seven SNPs (rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369) (D’>0.7) (Figure 1). Therefore, haplotype analysis needed to be performed. The haplotype of RETN SNPs rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369 (AGGCAGC) in the CI group had a 1.97 times higher occurrence rate than that in the control group (95% CI 1.07-3.60, P=0.026). In addition, the occurrence of CI also increased significantly. However, no evident or significant differences were observed between the CI group and the control group for the other 7 haplotypes (Table 5).

View Article: PubMed Central - PubMed

ABSTRACT

Recent research on genome-wide associations has implicated that the serum resistin level and its gene polymorphism are associated with cerebral infarction (CI) morbidity and prognosis, and could thereby regulate CI. This study aimed to investigate the association between the resistin single nucleotide polymorphism (SNP) and the susceptibility to CI in the Chinese Han population. A total of 550 CI patients and 313 healthy controls were genotyped. Nine SNPs of the resistin gene previously shown were sequenced and assessed for an association with CI. The numbers of GG genotype carriers of rs3219175 and rs3486119 in the CI group were significantly higher than those in the control group among the middle-aged group (aged 45-65), at 76% vs 67.9% (P=0.025) and 75.5% vs 67.9% (P=0.031). rs3219175 and rs34861192 were associated with CI in the dominant and superdominant models according to the genetic model analysis (P<0.05). Meanwhile, there was strong linkage disequilibrium among the rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369 sites. In a haplotype analysis, the occurrence rate of the haplotype AGGCAGC was 1.97 times (P<0.05) higher in the patient group than in the control group. In addition, the numbers of GG genotype carriers of rs3219175 and rs3486119 in the middle-aged male CI patients and the middle-aged small artery occlusion (SAO) CI patients were higher than those in the control group (P<0.05). In the Chinese Han middle-aged population, the GG gene type carriers of the resistin gene sites rs3219175 and rs34861192 had a high risk for CI onset, especially in middle-aged male patients and SAO CI in all middle-aged patients.

No MeSH data available.


Related in: MedlinePlus