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Exposure to Persistent Organic Pollutants Predicts Telomere Length in Older Age: Results from the Helsinki Birth Cohort Study

View Article: PubMed Central - PubMed

ABSTRACT

As the population ages, the occurrence of chronic pathologies becomes more common. Leukocyte telomere shortening associates to ageing and age-related diseases. Recent studies suggest that environmental chemicals can affect telomere length. Persistent organic pollutants (POPs) are most relevant, since they are ingested with foods, and accumulate in the body for a long time. This longitudinal study was undertaken to test if circulating POPs predict telomere length and shortening in elderly people. We studied 1082 subjects belonging to the Helsinki Birth Cohort Study (born 1934-1944), undergoing two visits (2001-2004 and 2011-2014). POPs (oxychlordane, trans-nonachlor, p, p’-DDE, PCB 153, BDE 47, BDE 153) were analysed at baseline. Relative telomere length was measured twice, ’10 years apart, by quantitative real-time PCR. Oxychlordane, trans-nonachlor and PCB-153 levels were significant predictors of telomere length and shortening. In men, we did not find a linear relationship between POPs exposure and telomere shortening. In women, a significant reduction across quartiles categories of oxychlordane and trans-nonachlor exposure was observed. Baseline characteristics of subjects in the highest POPs categories included higher levels of C-reactive protein and fasting glucose, and lower body fat percentage. This is one of few studies combining POPs and telomere length. Our results indicate that exposure to oxychlordane, trans-nonachlor and PCB 153 predicts telomere attrition. This finding is important because concentrations of POPs observed here occur in contemporary younger people, and may contribute to an accelerated ageing.

No MeSH data available.


Baseline measurements of body fat percentage (top panels), fasting plasma glucose (middle panels) and C-reactive protein levels (bottom panels), in relation to cumulative ranks of wet-weight serum POPs (oxychlordane, trans-nonachlor and PCB 153) concentrations as measured at the same baseline visit. Comparisons are adjusted for total serum cholesterol and triglycerides, age (all) and fat % (glucose and CRP). Categories 1 to 4 correspond to quartiles. Categories in men and women are calculated based on serum POPs levels within each sex-group. ***p≤0.001, vs all other categories, ‡p=0.059, 0.042 vs categories 1 and 2, respectively, and #p=0.005, 0.040, 0.069 vs category 1, 2 and 3 respectively.
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F3-ad-7-5-540: Baseline measurements of body fat percentage (top panels), fasting plasma glucose (middle panels) and C-reactive protein levels (bottom panels), in relation to cumulative ranks of wet-weight serum POPs (oxychlordane, trans-nonachlor and PCB 153) concentrations as measured at the same baseline visit. Comparisons are adjusted for total serum cholesterol and triglycerides, age (all) and fat % (glucose and CRP). Categories 1 to 4 correspond to quartiles. Categories in men and women are calculated based on serum POPs levels within each sex-group. ***p≤0.001, vs all other categories, ‡p=0.059, 0.042 vs categories 1 and 2, respectively, and #p=0.005, 0.040, 0.069 vs category 1, 2 and 3 respectively.

Mentions: After identifying the 3 POPs that were significant predictors of telomere attrition (oxychlordane, trans-nonachlor and PCB 153), their cumulative effect was examined by summing either their wet-weight concentrations or ranks and again stratifying the resulting sums into quartiles. As shown in Table 2, the cumulative POP concentration and score were significantly associated with a reduced telomere length at 10 years, independent of lipids, age, body fat percentage and diseases. Similarly, greater shortening during the 10-year observation period was significantly associated with cumulative POPs quartiles. Baseline (2001-2004) characteristics of subjects in the highest POPs categories included higher levels of C-reactive protein and fasting glucose, and lower body fat percentage (Fig. 3A).


Exposure to Persistent Organic Pollutants Predicts Telomere Length in Older Age: Results from the Helsinki Birth Cohort Study
Baseline measurements of body fat percentage (top panels), fasting plasma glucose (middle panels) and C-reactive protein levels (bottom panels), in relation to cumulative ranks of wet-weight serum POPs (oxychlordane, trans-nonachlor and PCB 153) concentrations as measured at the same baseline visit. Comparisons are adjusted for total serum cholesterol and triglycerides, age (all) and fat % (glucose and CRP). Categories 1 to 4 correspond to quartiles. Categories in men and women are calculated based on serum POPs levels within each sex-group. ***p≤0.001, vs all other categories, ‡p=0.059, 0.042 vs categories 1 and 2, respectively, and #p=0.005, 0.040, 0.069 vs category 1, 2 and 3 respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036950&req=5

F3-ad-7-5-540: Baseline measurements of body fat percentage (top panels), fasting plasma glucose (middle panels) and C-reactive protein levels (bottom panels), in relation to cumulative ranks of wet-weight serum POPs (oxychlordane, trans-nonachlor and PCB 153) concentrations as measured at the same baseline visit. Comparisons are adjusted for total serum cholesterol and triglycerides, age (all) and fat % (glucose and CRP). Categories 1 to 4 correspond to quartiles. Categories in men and women are calculated based on serum POPs levels within each sex-group. ***p≤0.001, vs all other categories, ‡p=0.059, 0.042 vs categories 1 and 2, respectively, and #p=0.005, 0.040, 0.069 vs category 1, 2 and 3 respectively.
Mentions: After identifying the 3 POPs that were significant predictors of telomere attrition (oxychlordane, trans-nonachlor and PCB 153), their cumulative effect was examined by summing either their wet-weight concentrations or ranks and again stratifying the resulting sums into quartiles. As shown in Table 2, the cumulative POP concentration and score were significantly associated with a reduced telomere length at 10 years, independent of lipids, age, body fat percentage and diseases. Similarly, greater shortening during the 10-year observation period was significantly associated with cumulative POPs quartiles. Baseline (2001-2004) characteristics of subjects in the highest POPs categories included higher levels of C-reactive protein and fasting glucose, and lower body fat percentage (Fig. 3A).

View Article: PubMed Central - PubMed

ABSTRACT

As the population ages, the occurrence of chronic pathologies becomes more common. Leukocyte telomere shortening associates to ageing and age-related diseases. Recent studies suggest that environmental chemicals can affect telomere length. Persistent organic pollutants (POPs) are most relevant, since they are ingested with foods, and accumulate in the body for a long time. This longitudinal study was undertaken to test if circulating POPs predict telomere length and shortening in elderly people. We studied 1082 subjects belonging to the Helsinki Birth Cohort Study (born 1934-1944), undergoing two visits (2001-2004 and 2011-2014). POPs (oxychlordane, trans-nonachlor, p, p’-DDE, PCB 153, BDE 47, BDE 153) were analysed at baseline. Relative telomere length was measured twice, ’10 years apart, by quantitative real-time PCR. Oxychlordane, trans-nonachlor and PCB-153 levels were significant predictors of telomere length and shortening. In men, we did not find a linear relationship between POPs exposure and telomere shortening. In women, a significant reduction across quartiles categories of oxychlordane and trans-nonachlor exposure was observed. Baseline characteristics of subjects in the highest POPs categories included higher levels of C-reactive protein and fasting glucose, and lower body fat percentage. This is one of few studies combining POPs and telomere length. Our results indicate that exposure to oxychlordane, trans-nonachlor and PCB 153 predicts telomere attrition. This finding is important because concentrations of POPs observed here occur in contemporary younger people, and may contribute to an accelerated ageing.

No MeSH data available.