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Exposure to Persistent Organic Pollutants Predicts Telomere Length in Older Age: Results from the Helsinki Birth Cohort Study

View Article: PubMed Central - PubMed

ABSTRACT

As the population ages, the occurrence of chronic pathologies becomes more common. Leukocyte telomere shortening associates to ageing and age-related diseases. Recent studies suggest that environmental chemicals can affect telomere length. Persistent organic pollutants (POPs) are most relevant, since they are ingested with foods, and accumulate in the body for a long time. This longitudinal study was undertaken to test if circulating POPs predict telomere length and shortening in elderly people. We studied 1082 subjects belonging to the Helsinki Birth Cohort Study (born 1934-1944), undergoing two visits (2001-2004 and 2011-2014). POPs (oxychlordane, trans-nonachlor, p, p’-DDE, PCB 153, BDE 47, BDE 153) were analysed at baseline. Relative telomere length was measured twice, ’10 years apart, by quantitative real-time PCR. Oxychlordane, trans-nonachlor and PCB-153 levels were significant predictors of telomere length and shortening. In men, we did not find a linear relationship between POPs exposure and telomere shortening. In women, a significant reduction across quartiles categories of oxychlordane and trans-nonachlor exposure was observed. Baseline characteristics of subjects in the highest POPs categories included higher levels of C-reactive protein and fasting glucose, and lower body fat percentage. This is one of few studies combining POPs and telomere length. Our results indicate that exposure to oxychlordane, trans-nonachlor and PCB 153 predicts telomere attrition. This finding is important because concentrations of POPs observed here occur in contemporary younger people, and may contribute to an accelerated ageing.

No MeSH data available.


Telomere length at the final visit, in relation to serum POPs concentrations as measured at baseline. The population is stratified based on quartile categories of each POP in men (A) and women (B). Categories in men and women are calculated based on serum wet-weight POPs levels within each sex-group. Analysis is adjusted for total serum cholesterol and triglycerides levels. *p≤0.05.
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F2-ad-7-5-540: Telomere length at the final visit, in relation to serum POPs concentrations as measured at baseline. The population is stratified based on quartile categories of each POP in men (A) and women (B). Categories in men and women are calculated based on serum wet-weight POPs levels within each sex-group. Analysis is adjusted for total serum cholesterol and triglycerides levels. *p≤0.05.

Mentions: In men and women, percentile categories were calculated according to the distribution of serum POP levels separately for men and women. Men did not show a clear exposure-response pattern (Fig. 2A). Consistently, glycaemia did not show a significant trend and C-reactive protein showed a U-shaped relationship within the cumulative POPs score categories (Fig. 3B). In women telomere length after 10 years showed a significant reduction across quartile categories of oxychlordane and trans-nonachlor exposure, and a trend across PCB 153 categories (Fig. 2B). Consistently, plasma glucose levels were significantly higher in the highest quartile of the cumulative POPs score and progressively elevated in proportion to, and C-reactive protein showed the same trend (Fig. 3C).


Exposure to Persistent Organic Pollutants Predicts Telomere Length in Older Age: Results from the Helsinki Birth Cohort Study
Telomere length at the final visit, in relation to serum POPs concentrations as measured at baseline. The population is stratified based on quartile categories of each POP in men (A) and women (B). Categories in men and women are calculated based on serum wet-weight POPs levels within each sex-group. Analysis is adjusted for total serum cholesterol and triglycerides levels. *p≤0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036950&req=5

F2-ad-7-5-540: Telomere length at the final visit, in relation to serum POPs concentrations as measured at baseline. The population is stratified based on quartile categories of each POP in men (A) and women (B). Categories in men and women are calculated based on serum wet-weight POPs levels within each sex-group. Analysis is adjusted for total serum cholesterol and triglycerides levels. *p≤0.05.
Mentions: In men and women, percentile categories were calculated according to the distribution of serum POP levels separately for men and women. Men did not show a clear exposure-response pattern (Fig. 2A). Consistently, glycaemia did not show a significant trend and C-reactive protein showed a U-shaped relationship within the cumulative POPs score categories (Fig. 3B). In women telomere length after 10 years showed a significant reduction across quartile categories of oxychlordane and trans-nonachlor exposure, and a trend across PCB 153 categories (Fig. 2B). Consistently, plasma glucose levels were significantly higher in the highest quartile of the cumulative POPs score and progressively elevated in proportion to, and C-reactive protein showed the same trend (Fig. 3C).

View Article: PubMed Central - PubMed

ABSTRACT

As the population ages, the occurrence of chronic pathologies becomes more common. Leukocyte telomere shortening associates to ageing and age-related diseases. Recent studies suggest that environmental chemicals can affect telomere length. Persistent organic pollutants (POPs) are most relevant, since they are ingested with foods, and accumulate in the body for a long time. This longitudinal study was undertaken to test if circulating POPs predict telomere length and shortening in elderly people. We studied 1082 subjects belonging to the Helsinki Birth Cohort Study (born 1934-1944), undergoing two visits (2001-2004 and 2011-2014). POPs (oxychlordane, trans-nonachlor, p, p’-DDE, PCB 153, BDE 47, BDE 153) were analysed at baseline. Relative telomere length was measured twice, ’10 years apart, by quantitative real-time PCR. Oxychlordane, trans-nonachlor and PCB-153 levels were significant predictors of telomere length and shortening. In men, we did not find a linear relationship between POPs exposure and telomere shortening. In women, a significant reduction across quartiles categories of oxychlordane and trans-nonachlor exposure was observed. Baseline characteristics of subjects in the highest POPs categories included higher levels of C-reactive protein and fasting glucose, and lower body fat percentage. This is one of few studies combining POPs and telomere length. Our results indicate that exposure to oxychlordane, trans-nonachlor and PCB 153 predicts telomere attrition. This finding is important because concentrations of POPs observed here occur in contemporary younger people, and may contribute to an accelerated ageing.

No MeSH data available.