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Early Response in Cellulitis: A Prospective Study of Dynamics and Predictors

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ABSTRACT

In this prospective study of cellulitis, several nonpharmacological factors were associated with lack of early response. Such early nonresponse was rarely related to inappropriate therapy but strongly predictive of early treatment escalation, suggesting that broadening antibiotic treatment often may be premature.

No MeSH data available.


Related in: MedlinePlus

Clinical course after treatment. Status at end of treatment and posttreatment was determined by a telephone consultation scheduled approximately 2 weeks after cessation of therapy. Signs of residual inflammation (red/rose/purple discoloration, tenderness, warmth) and deterioration (symptom increase or new antibiotic course) after treatment were registered. Readmissions for skin and soft tissue infection (SSTI) within 30 days are also shown. The number of cases with indeterminate outcome (≥1 parameters missing) at end of treatment and posttreatment were 25 and 15, respectively.
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CIW463F2: Clinical course after treatment. Status at end of treatment and posttreatment was determined by a telephone consultation scheduled approximately 2 weeks after cessation of therapy. Signs of residual inflammation (red/rose/purple discoloration, tenderness, warmth) and deterioration (symptom increase or new antibiotic course) after treatment were registered. Readmissions for skin and soft tissue infection (SSTI) within 30 days are also shown. The number of cases with indeterminate outcome (≥1 parameters missing) at end of treatment and posttreatment were 25 and 15, respectively.

Mentions: More than half of the patients had residual signs of inflammation at EOT (Figure 2). The median duration of the recall period (ie, the time from EOT to the telephone interview) was slightly longer in the cases with residual inflammation at EOT (22 days vs 20 days; P = .09). Signs of inflammation were still common at the posttreatment evaluation (Figure 2). Among 112 cases with residual inflammation at EOT, 18 (16%) had deterioration or readmission posttreatment (as in the definition of clinical failure), compared with 2 of 79 (3%) cases without such residual inflammation (odds ratio, 7.4 [95% confidence interval, 1.7–32.8]; P = .003). Clinical course data limited to the cases without discordant initial therapy showed a pattern equal to cases overall (Supplementary Figure).Figure 2.


Early Response in Cellulitis: A Prospective Study of Dynamics and Predictors
Clinical course after treatment. Status at end of treatment and posttreatment was determined by a telephone consultation scheduled approximately 2 weeks after cessation of therapy. Signs of residual inflammation (red/rose/purple discoloration, tenderness, warmth) and deterioration (symptom increase or new antibiotic course) after treatment were registered. Readmissions for skin and soft tissue infection (SSTI) within 30 days are also shown. The number of cases with indeterminate outcome (≥1 parameters missing) at end of treatment and posttreatment were 25 and 15, respectively.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5036916&req=5

CIW463F2: Clinical course after treatment. Status at end of treatment and posttreatment was determined by a telephone consultation scheduled approximately 2 weeks after cessation of therapy. Signs of residual inflammation (red/rose/purple discoloration, tenderness, warmth) and deterioration (symptom increase or new antibiotic course) after treatment were registered. Readmissions for skin and soft tissue infection (SSTI) within 30 days are also shown. The number of cases with indeterminate outcome (≥1 parameters missing) at end of treatment and posttreatment were 25 and 15, respectively.
Mentions: More than half of the patients had residual signs of inflammation at EOT (Figure 2). The median duration of the recall period (ie, the time from EOT to the telephone interview) was slightly longer in the cases with residual inflammation at EOT (22 days vs 20 days; P = .09). Signs of inflammation were still common at the posttreatment evaluation (Figure 2). Among 112 cases with residual inflammation at EOT, 18 (16%) had deterioration or readmission posttreatment (as in the definition of clinical failure), compared with 2 of 79 (3%) cases without such residual inflammation (odds ratio, 7.4 [95% confidence interval, 1.7–32.8]; P = .003). Clinical course data limited to the cases without discordant initial therapy showed a pattern equal to cases overall (Supplementary Figure).Figure 2.

View Article: PubMed Central - PubMed

ABSTRACT

In this prospective study of cellulitis, several nonpharmacological factors were associated with lack of early response. Such early nonresponse was rarely related to inappropriate therapy but strongly predictive of early treatment escalation, suggesting that broadening antibiotic treatment often may be premature.

No MeSH data available.


Related in: MedlinePlus