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Impact of Opioid Substitution Therapy on Antiretroviral Therapy Outcomes: A Systematic Review and Meta-Analysis

View Article: PubMed Central - PubMed

ABSTRACT

This meta-analysis provides strong evidence that opioid substitution therapy improves several key outcomes of the HIV care continuum among people who inject drugs, including recruitment onto antiretroviral therapy, retention in care, adherence, and viral suppression.

No MeSH data available.


Related in: MedlinePlus

Forest plot of the effect of opioid substitution therapy on antiretroviral therapy (ART) discontinuation or attrition among people who inject drugs (PWID), defined as the proportion of those on ART who were lost to follow-up or discontinued ART during follow-up. I2 and P value are measures of between-study heterogeneity. Abbreviations: CI, confidence interval; N, total sample size of PWID; OR, odds ratio; time on ART, average time on ART for study participants.
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CIW416F4: Forest plot of the effect of opioid substitution therapy on antiretroviral therapy (ART) discontinuation or attrition among people who inject drugs (PWID), defined as the proportion of those on ART who were lost to follow-up or discontinued ART during follow-up. I2 and P value are measures of between-study heterogeneity. Abbreviations: CI, confidence interval; N, total sample size of PWID; OR, odds ratio; time on ART, average time on ART for study participants.

Mentions: There were 7 eligible studies describing ART discontinuation/attrition (Supplementary Table 6). The average time on ART exceeded 12 months for all 5 studies reporting it. The pooled estimate found a 23% reduction in the odds of ART discontinuation if on OST (OR, 0.77; 95% CI, .63–.95; P = .01) with moderate heterogeneity (I2 = 59%; P = .02; Figure 4). There was no significant difference in effect by sex, duration of ART, or when studies with inactive PWID were removed.Figure 4.


Impact of Opioid Substitution Therapy on Antiretroviral Therapy Outcomes: A Systematic Review and Meta-Analysis
Forest plot of the effect of opioid substitution therapy on antiretroviral therapy (ART) discontinuation or attrition among people who inject drugs (PWID), defined as the proportion of those on ART who were lost to follow-up or discontinued ART during follow-up. I2 and P value are measures of between-study heterogeneity. Abbreviations: CI, confidence interval; N, total sample size of PWID; OR, odds ratio; time on ART, average time on ART for study participants.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036913&req=5

CIW416F4: Forest plot of the effect of opioid substitution therapy on antiretroviral therapy (ART) discontinuation or attrition among people who inject drugs (PWID), defined as the proportion of those on ART who were lost to follow-up or discontinued ART during follow-up. I2 and P value are measures of between-study heterogeneity. Abbreviations: CI, confidence interval; N, total sample size of PWID; OR, odds ratio; time on ART, average time on ART for study participants.
Mentions: There were 7 eligible studies describing ART discontinuation/attrition (Supplementary Table 6). The average time on ART exceeded 12 months for all 5 studies reporting it. The pooled estimate found a 23% reduction in the odds of ART discontinuation if on OST (OR, 0.77; 95% CI, .63–.95; P = .01) with moderate heterogeneity (I2 = 59%; P = .02; Figure 4). There was no significant difference in effect by sex, duration of ART, or when studies with inactive PWID were removed.Figure 4.

View Article: PubMed Central - PubMed

ABSTRACT

This meta-analysis provides strong evidence that opioid substitution therapy improves several key outcomes of the HIV care continuum among people who inject drugs, including recruitment onto antiretroviral therapy, retention in care, adherence, and viral suppression.

No MeSH data available.


Related in: MedlinePlus