Limits...
Impact of Opioid Substitution Therapy on Antiretroviral Therapy Outcomes: A Systematic Review and Meta-Analysis

View Article: PubMed Central - PubMed

ABSTRACT

This meta-analysis provides strong evidence that opioid substitution therapy improves several key outcomes of the HIV care continuum among people who inject drugs, including recruitment onto antiretroviral therapy, retention in care, adherence, and viral suppression.

No MeSH data available.


Forest plot of the effect of opioid substitution therapy on adherence to antiretroviral therapy (ART) among people who inject drugs (PWID), defined as the proportion achieving a defined threshold of ART adherence, whether self-reported or objectively measured. I2 and P value are measures of between-study heterogeneity. Abbreviations: CI, confidence interval; measure, method of measurement of adherence; N, total sample size of PWID; OR, odds ratio; threshold, percentage of doses taken to indicate adherence.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC5036913&req=5

CIW416F2: Forest plot of the effect of opioid substitution therapy on adherence to antiretroviral therapy (ART) among people who inject drugs (PWID), defined as the proportion achieving a defined threshold of ART adherence, whether self-reported or objectively measured. I2 and P value are measures of between-study heterogeneity. Abbreviations: CI, confidence interval; measure, method of measurement of adherence; N, total sample size of PWID; OR, odds ratio; threshold, percentage of doses taken to indicate adherence.

Mentions: Five studies reported on the effect of OST on adherence (Figure 2; Supplementary Table 3). Only 2 studies used an objective measure of adherence (pharmacy refills), whereas others used self-report, with adherence thresholds ranging from 80% to 100% of doses. In the pooled estimate, OST use was associated with a 2-fold increase in adherence (OR, 2.14; 95% CI, 1.41–3.26; P < .001), with high between-study heterogeneity (I2 = 74%; P = .004). In a subgroup analysis, the effect was higher for studies using self-reported adherence (OR, 2.86; 95% CI, 1.35–6.04; n = 3) compared with using pharmacy refill (OR, 1.88; 95% CI, 1.11–3.17; n = 2), although both the latter studies were from Vancouver. In other subgroup analyses, there was no effect of the adherence threshold, proportion of females in the study, or geographical region.Figure 2.


Impact of Opioid Substitution Therapy on Antiretroviral Therapy Outcomes: A Systematic Review and Meta-Analysis
Forest plot of the effect of opioid substitution therapy on adherence to antiretroviral therapy (ART) among people who inject drugs (PWID), defined as the proportion achieving a defined threshold of ART adherence, whether self-reported or objectively measured. I2 and P value are measures of between-study heterogeneity. Abbreviations: CI, confidence interval; measure, method of measurement of adherence; N, total sample size of PWID; OR, odds ratio; threshold, percentage of doses taken to indicate adherence.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036913&req=5

CIW416F2: Forest plot of the effect of opioid substitution therapy on adherence to antiretroviral therapy (ART) among people who inject drugs (PWID), defined as the proportion achieving a defined threshold of ART adherence, whether self-reported or objectively measured. I2 and P value are measures of between-study heterogeneity. Abbreviations: CI, confidence interval; measure, method of measurement of adherence; N, total sample size of PWID; OR, odds ratio; threshold, percentage of doses taken to indicate adherence.
Mentions: Five studies reported on the effect of OST on adherence (Figure 2; Supplementary Table 3). Only 2 studies used an objective measure of adherence (pharmacy refills), whereas others used self-report, with adherence thresholds ranging from 80% to 100% of doses. In the pooled estimate, OST use was associated with a 2-fold increase in adherence (OR, 2.14; 95% CI, 1.41–3.26; P < .001), with high between-study heterogeneity (I2 = 74%; P = .004). In a subgroup analysis, the effect was higher for studies using self-reported adherence (OR, 2.86; 95% CI, 1.35–6.04; n = 3) compared with using pharmacy refill (OR, 1.88; 95% CI, 1.11–3.17; n = 2), although both the latter studies were from Vancouver. In other subgroup analyses, there was no effect of the adherence threshold, proportion of females in the study, or geographical region.Figure 2.

View Article: PubMed Central - PubMed

ABSTRACT

This meta-analysis provides strong evidence that opioid substitution therapy improves several key outcomes of the HIV care continuum among people who inject drugs, including recruitment onto antiretroviral therapy, retention in care, adherence, and viral suppression.

No MeSH data available.