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Femoral Bone Marrow Insulin Sensitivity Is Increased by Resistance Training in Elderly Female Offspring of Overweight and Obese Mothers

View Article: PubMed Central - PubMed

ABSTRACT

Bone marrow insulin sensitivity may be an important factor for bone health in addition to bone mineral density especially in insulin resistant conditions. First we aimed to study if prenatal maternal obesity plays a role in determining bone marrow insulin sensitivity in elderly female offspring. Secondly we studied if a four-month individualized resistance training intervention increases bone marrow insulin sensitivity in elderly female offspring and whether this possible positive outcome is regulated by the offspring’s mother’s obesity status. 37 frail elderly females (mean age 71.9 ± 3.1 years) of which 20 were offspring of lean/normal-weight mothers (OLM, maternal BMI ≤ 26.3 kg/m2) and 17 were offspring of obese/overweight mothers (OOM, maternal BMI ≥ 28.1 kg/m2) were studied before and after a four-month individualized resistance training intervention. Nine age- and sex-matched non-frail controls (maternal BMI ≤ 26.3 kg/m2) were studied at baseline. Femoral bone marrow (FBM) and vertebral bone marrow (VBM) insulin sensitivity were measured using [18F]fluoro-2-deoxy-D-glucose positron emission tomography with computer tomography under hyperinsulinemic euglycemic clamp. We found that bone marrow insulin sensitivity was not related to maternal obesity status but FBM insulin sensitivity correlated with whole body insulin sensitivity (R = 0.487, p = 0.001). A four-month resistance training intervention increased FBM insulin sensitivity by 47% (p = 0.006) only in OOM, while VBM insulin sensitivity remained unchanged regardless of the maternal obesity status. In conclusion, FBM and VBM glucose metabolism reacts differently to a four-month resistance training intervention in elderly women according to their maternal obesity status.

Trial registration: ClinicalTrials.gov NCT01931540

No MeSH data available.


Related in: MedlinePlus

Tissue-specific insulin-stimulated glucose uptake of control, frail (OLM + OOM), OLM and OOM at baseline.At baseline, there were no differences between the groups. VBM: vertebral bone marrow, FBM: femoral bone marrow, Psoas: psoas muscle, SAT: subcutaneous adipose tissue, GU: glucose uptake, OLM: offspring of lean/normal-weight mothers, OOM: offspring of obese/overweight mothers. Results are shown as mean ± SD.
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pone.0163723.g003: Tissue-specific insulin-stimulated glucose uptake of control, frail (OLM + OOM), OLM and OOM at baseline.At baseline, there were no differences between the groups. VBM: vertebral bone marrow, FBM: femoral bone marrow, Psoas: psoas muscle, SAT: subcutaneous adipose tissue, GU: glucose uptake, OLM: offspring of lean/normal-weight mothers, OOM: offspring of obese/overweight mothers. Results are shown as mean ± SD.

Mentions: Statistical analyses were performed with SPSS software for MacOS (version 22.00). Data is presented as mean ± standard deviation (SD). The Shapiro–Wilk test was used to assess the normality of variables. Differences between the groups at baseline (results of Table 1 and Fig 3) were tested with parametric ANOVA (age, BMI, body fat %, systolic BP, diastolic BP, fP-glucose, maternal BMI, handgrip strength, VBM fat/water -ratio, M-value, VBM GU, FBM GU, psoas GU) or with Kruskal-Wallis test (waist/hip ratio, fS-insulin, SAT GU). ANCOVA was used to adjust for the possible effect of muscle strength at baseline. The effects of exercise between and within the groups were assessed with repeated measures ANOVA as a linear mixed model with unstructured covariance structure (results of Table 2 and Fig 4). Bonferroni adjusted p-values were used in pairwise comparisons between the time points. Differences between categorical data were tested with Chi-square test. Associations of bone marrow insulin sensitivity, the main outcome variable, with other variables were tested with Spearman (ΔFBM GU vs ΔM-value in OOM, ΔVBM vs ΔM-value in OOM) or Pearson (all the other correlation testing) correlation analysis. A p-value of less than 0.05 was considered significant.


Femoral Bone Marrow Insulin Sensitivity Is Increased by Resistance Training in Elderly Female Offspring of Overweight and Obese Mothers
Tissue-specific insulin-stimulated glucose uptake of control, frail (OLM + OOM), OLM and OOM at baseline.At baseline, there were no differences between the groups. VBM: vertebral bone marrow, FBM: femoral bone marrow, Psoas: psoas muscle, SAT: subcutaneous adipose tissue, GU: glucose uptake, OLM: offspring of lean/normal-weight mothers, OOM: offspring of obese/overweight mothers. Results are shown as mean ± SD.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036877&req=5

pone.0163723.g003: Tissue-specific insulin-stimulated glucose uptake of control, frail (OLM + OOM), OLM and OOM at baseline.At baseline, there were no differences between the groups. VBM: vertebral bone marrow, FBM: femoral bone marrow, Psoas: psoas muscle, SAT: subcutaneous adipose tissue, GU: glucose uptake, OLM: offspring of lean/normal-weight mothers, OOM: offspring of obese/overweight mothers. Results are shown as mean ± SD.
Mentions: Statistical analyses were performed with SPSS software for MacOS (version 22.00). Data is presented as mean ± standard deviation (SD). The Shapiro–Wilk test was used to assess the normality of variables. Differences between the groups at baseline (results of Table 1 and Fig 3) were tested with parametric ANOVA (age, BMI, body fat %, systolic BP, diastolic BP, fP-glucose, maternal BMI, handgrip strength, VBM fat/water -ratio, M-value, VBM GU, FBM GU, psoas GU) or with Kruskal-Wallis test (waist/hip ratio, fS-insulin, SAT GU). ANCOVA was used to adjust for the possible effect of muscle strength at baseline. The effects of exercise between and within the groups were assessed with repeated measures ANOVA as a linear mixed model with unstructured covariance structure (results of Table 2 and Fig 4). Bonferroni adjusted p-values were used in pairwise comparisons between the time points. Differences between categorical data were tested with Chi-square test. Associations of bone marrow insulin sensitivity, the main outcome variable, with other variables were tested with Spearman (ΔFBM GU vs ΔM-value in OOM, ΔVBM vs ΔM-value in OOM) or Pearson (all the other correlation testing) correlation analysis. A p-value of less than 0.05 was considered significant.

View Article: PubMed Central - PubMed

ABSTRACT

Bone marrow insulin sensitivity may be an important factor for bone health in addition to bone mineral density especially in insulin resistant conditions. First we aimed to study if prenatal maternal obesity plays a role in determining bone marrow insulin sensitivity in elderly female offspring. Secondly we studied if a four-month individualized resistance training intervention increases bone marrow insulin sensitivity in elderly female offspring and whether this possible positive outcome is regulated by the offspring’s mother’s obesity status. 37 frail elderly females (mean age 71.9 ± 3.1 years) of which 20 were offspring of lean/normal-weight mothers (OLM, maternal BMI ≤ 26.3 kg/m2) and 17 were offspring of obese/overweight mothers (OOM, maternal BMI ≥ 28.1 kg/m2) were studied before and after a four-month individualized resistance training intervention. Nine age- and sex-matched non-frail controls (maternal BMI ≤ 26.3 kg/m2) were studied at baseline. Femoral bone marrow (FBM) and vertebral bone marrow (VBM) insulin sensitivity were measured using [18F]fluoro-2-deoxy-D-glucose positron emission tomography with computer tomography under hyperinsulinemic euglycemic clamp. We found that bone marrow insulin sensitivity was not related to maternal obesity status but FBM insulin sensitivity correlated with whole body insulin sensitivity (R = 0.487, p = 0.001). A four-month resistance training intervention increased FBM insulin sensitivity by 47% (p = 0.006) only in OOM, while VBM insulin sensitivity remained unchanged regardless of the maternal obesity status. In conclusion, FBM and VBM glucose metabolism reacts differently to a four-month resistance training intervention in elderly women according to their maternal obesity status.

Trial registration: ClinicalTrials.gov NCT01931540

No MeSH data available.


Related in: MedlinePlus